Rhein inhibits glucose uptake in Ehrlich ascites tumor cells by alteration of membrane-associated functions

S, Castiglione; Fanciulli, Maurizio; Bruno, Tiziana; Evangelista, Michele; Carlo, C. Del; Paggi, Marco G.; Chersi, Alberto; Floridi, Aristide

doi:10.1097/00001813-199306000-00019

Cited by 35 publications

(20 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This inhibition has been postulated to be an interaction of rhein with cell membranes that results in an alteration of membrane-associated functions. 58 Further study suggests that this anthraquinone induced enhancement in CD95 and its ligands, and subsequent apoptotic effect in HepG2 cells. 47 In addition, this anthraquinone induces apoptosis in HL-60 cells through the mitochondrial death pathway by causing the loss of mitochondrial membrane potential, cytochrome c release, and cleavage of Bid protein.…”

Section: Induction Of Apoptosismentioning

confidence: 90%

Anti‐cancer properties of anthraquinones from rhubarb

Huang¹,

Lu²,

Shen³

et al. 2006

Medicinal Research Reviews

500

296

View full text Add to dashboard Cite

Rhubarb has been used as a traditional Chinese medicine since ancient times and today it is still present in various herbal preparations. In this review the toxicological and anti-neoplastic potentials of the main anthraquinones from Rhubarb, Rheum palmatum, will be highlighted. It is interesting to note that although the chemical structures of various anthraquinones in this plant are similar, their bioactivities are rather different. The most abundant anthraquinone of rhubarb, emodin, was capable of inhibiting cellular proliferation, induction of apoptosis, and prevention of metastasis. These capabilities are reported to act through tyrosine kinases, phosphoinositol 3-kinase (PI3K), protein kinase C (PKC), NF-kappa B (NF-kappaB), and mitogen-activated protein kinase (MAPK) signaling cascades. Aloe-emodin is another major component in rhubarb found to have anti-tumor properties. Its anti-proliferative property has been demonstrated to be through the p53 and its downstream p21 pathway. Our recent proteomic study also suggests that the molecular targets of these two anthraquinones are different. However, both components were found to be able to potentiate the anti-proliferation of various chemotherapeutic agents. Rhein is the other major rhubarb anthraquinone, although less well studied. This compound could effectively inhibit the uptake of glucose in tumor cells, caused changes in membrane-associated functions and led to cell death. Interestingly, all three major rhubarb anthraquinones were reported to have in vitro phototoxic. This re-evaluation of an old remedy suggests that several bioactive anthraquinones of rhubarb possess promising anti-cancer properties and could have a broad therapeutic potential.

show abstract

Section: Induction Of Apoptosismentioning

confidence: 90%

Anti‐cancer properties of anthraquinones from rhubarb

Huang¹,

Lu²,

Shen³

et al. 2006

Medicinal Research Reviews

500

296

View full text Add to dashboard Cite

show abstract

“…Reports of the pharmacology of diacetyl rhein show that it can have a wide range of biological activity [12][13][14]. What is perhaps more significant is that using the protocol outlined in this paper, it is possible to determine the in vivo actions of various compounds on their ability to inhibit turnover.…”

Section: Inflamm Resmentioning

confidence: 96%

Anin vivo investigation of the effect of anthraquinones on the turnover of aggrecans in spontaneous osteoarthritis in the guinea pig

et al. 1995

View full text Add to dashboard Cite

We present details of a method which allows for the determination of chondroitin sulphate turnover in vivo using the guinea pig. Such methods have been utilised to examine the effects of diacetyl rhein, a compound with purported anti-osteoarthritic activity, and several related anthraquinone analogues on the turnover of chondroitin. Since the guinea pig develops spontaneous osteoarthritis, this may give useful information on the potential for such compounds to inhibit the progression of osteoarthritis. The results show that several of the anthraquinones are capable of reducing the turnover of chondroitin 4- but not 6-sulphate. This may indicate potential mechanisms for the breakdown of guinea pig cartilage aggrecans. We propose that these techniques could be useful for the screening of chemical agents with useful activity against osteoarthritis.

show abstract

“…It has also been shown to influence cell growth and apoptosis in several human cancer cell lines such as cervical cancer Ca Ski (120), colon adenocarcinoma CaCo-2 (245), glioma U-373MG (74), hepatocellular carcinoma BEL-7402 (265), hepatoblastoma HepG2 (146), lung cancer A549 (108), promyelocytic leukemia HL-60 (181), and human tongue SSC-4 cancer cell lines (42,150). Moreover, rhein can inhibit the uptake and glycolysis of glucose and protein synthesis in cancer cells (29,30,73). Although it has been reported that increased expression of p53, p21, and CD96 may be responsible for the apoptosis of human hepatoblastoma HepG2 cell lines induced by rhein in a similar manner to AE (146), the molecular mechanisms by which rhein influences cell growth and apoptosis of cancer cells differ from AE.…”

Section: The Inhibitory Mechanisms Of Natural Compounds Against Npc Smentioning

confidence: 99%

Potential Therapeutic Molecular Targets for Nasopharyngeal Carcinoma

Chen¹

2012

Carcinogenesis, Diagnosis, and Molecular Targeted Treatment for Nasopharyngeal Carcinoma

View full text Add to dashboard Cite

Rhein inhibits glucose uptake in Ehrlich ascites tumor cells by alteration of membrane-associated functions

Cited by 35 publications

References 0 publications

Anti‐cancer properties of anthraquinones from rhubarb

Anti‐cancer properties of anthraquinones from rhubarb

Anin vivo investigation of the effect of anthraquinones on the turnover of aggrecans in spontaneous osteoarthritis in the guinea pig

Potential Therapeutic Molecular Targets for Nasopharyngeal Carcinoma

Contact Info

Product

Resources

About