Rhegmatogenous retinal detachments: primary reattachment rates and visual outcomes over a 4-year period

Murtagh, Patrick; Stephenson, Kirk; Rhatigan, Maedbh; McElnea, Elizabeth; Connell, Paul; Keegan, David

doi:10.1007/s11845-019-02084-7

Cited by 13 publications

(17 citation statements)

References 22 publications

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“…Ziel der primär operativen Therapie ist das Wiederanlegen der Netzhaut [ 24 ]. Ein anatomischer Erfolg wird dabei in 85–90 % der Operationen erreicht [ 9 , 16 , 17 , 21 ]. Der funktionelle Erfolg ist v. a. abhängig von einer Mitbeteiligung der Makula [ 6 , 13 ].…”

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Amotio-retinae-Versorgung während der Corona-Pandemie

2020

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Amotio-retinae-Versorgung während der Corona-Pandemie Suchten Patienten mit Netzhautablösung während der Corona-Pandemie später den Augenarzt auf? Ergebnisse aus einer deutschen Universitätsaugenklinik Eine Netzhautablösung stellt einen ophthalmologischen Notfall dar. Eine Verzögerung der Diagnose oder Therapie kann die Visusprognose reduzieren. Aus aktuellen Presseberichten geht hervor, dass Notfallpatienten beispielsweise mit Myokardinfarkt oder Apoplex aus Angst vor einer Ansteckung mit dem Coronavirus erst deutlich verspätet einen Arzt aufsuchen und somit die Diagnose und Therapie verschleppen. Die vorliegende Arbeit untersucht, ob die Corona-Pandemie Auswirkung auf die Versorgung und den präoperativen Visus von Patienten mit Netzhautablösung hatte.

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Amotio-retinae-Versorgung während der Corona-Pandemie

2020

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“…Retinal detachment (RD), the separation of the neural retina from the underlying retinal pigment epithelium (RPE), is a well-known cause of visual loss and has a major impact on quality of life 1 . Although the retina can be reattached by various surgical procedures, the final visual outcome is often unsatisfactory [2][3][4][5][6][7][8] .…”

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confidence: 99%

ROCK inhibition reduces morphological and functional damage to rod synapses after retinal injury

Halasz

Zarbin

Davidow

et al. 2021

Sci Rep

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Retinal detachment (RD) causes damage, including disjunction, of the rod photoreceptor-bipolar synapse, which disrupts vision and may contribute to the poor visual recovery observed after retinal reattachment surgery. We created a model of iatrogenic RD in adult female pigs to study damage to the rod-bipolar synapse after injury and the ability of a highly specific Rho-kinase (ROCK) inhibitor to preserve synaptic structure and function. This model mimics procedures used in humans when viral vectors or cells are injected subretinally for treatment of retinal disease. Synaptic disjunction by retraction of rod spherules, quantified by image analysis of confocal sections, was present 2 h after detachment and remained 2 days later even though the retina had spontaneously reattached by then. Moreover, spherule retraction occurred in attached retina 1–2 cms from detached retina. Synaptic damage was significantly reduced by ROCK inhibition in detached retina whether injected subretinally or intravitreally. Dark-adapted full-field electroretinograms were recorded in reattached retinas to assess rod-specific function. Reduction in synaptic injury correlated with increases in rod-driven responses in drug-treated eyes. Thus, ROCK inhibition helps prevent synaptic damage and improves functional outcomes after retinal injury and may be a useful adjunctive treatment in iatrogenic RD and other retinal degenerative diseases.

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“…This study was approved by the Mater Misericordiae University Hospital Institutional Review Board (IRB) conducted by the declaration of Helsinki and the Irish Data Protection Act. 8,9 Inclusion Criteria All primary rhegmatogenous retinal detachment patients above 10 years of age.…”

Section: Methodsmentioning

confidence: 99%

Anatomical and Functional Outcome of Retinal Detachment Surgery

Mishra

Chaudhary

Singh

et al. 2022

UPJO

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Objective: To study the anatomical status and functional outcome of Pars Plana Vitrectomy surgery in rhegmatogenous retinal detachment (RRD) at a tertiary eye care center in India. Material, Patients and Method: This is a prospective, noncomparative, consecutive, interventional study of rhegmatogenous retinal detachment managed with Pars Plana Vitrectomy surgery performed in the Regional Institute of Ophthalmology, Prayagraj, India. 40 patients of 40 eyes (26 phakic 65%, 14 pseudophakic 35%) with retinal detachment were treated by primary pars plana vitrectomy with 6 months of follow-up. Result: A total of 40 patients (40 eyes) were operated, 18 males and 2 females, with age, ranges from 17 years to 90 years. After surgery, anatomically retinal reattachment was achieved in 40 (100%). Improved best-corrected visual acuity (BCVA) was seen in 38 (90%) patients, whereas in 2 (5%) patient BCVA was not improving and deteriorated from pre-operative in another 2 (5%) patient. There was no significant difference was found in the pseudophakic and phakic eye in functional outcome. Conclusion: Rhegmatogenous retinal detachment is one of the common causes of visual impairment and blindness. Timely surgical management with Pars Plana Vitrectomy surgery can give good anatomical and visual outcome.

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Rhegmatogenous retinal detachments: primary reattachment rates and visual outcomes over a 4-year period

Cited by 13 publications

References 22 publications

Amotio-retinae-Versorgung während der Corona-Pandemie

Amotio-retinae-Versorgung während der Corona-Pandemie

ROCK inhibition reduces morphological and functional damage to rod synapses after retinal injury

Anatomical and Functional Outcome of Retinal Detachment Surgery

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