RhCl(CO)(PPh 3 ) 2 catalyzed α-alkylation of ketones with alcohols

Microbial transformations of 4′-methylchalcones as an efficient method of obtaining novel alcohol and dihydrochalcone derivatives with antimicrobial activity

“…4′-Methyl-α,β-dihydrochalcone (1a), white solid, mp 61–63 °C (lit. 24 61–63 °C); 1 H NMR (600 MHz, CDCl 3 ): δ 7.90–7.83 (2H, m, H-2′, H-6′, AA′BB′), 7.33–7.24 (6H, m, H-2, H-3, H-5, H-6, H-3′, H-5′), 7.24–7.19 (1H, m, H-4), 3.32–3.25 (2H, m, H-α), 3.11–3.02 (2H, m, H-β), 2.41 (3H, s, C-4′-C ); 13 C NMR (150 MHz, CDCl 3 ): δ 199.00 (C̲ O), 143.94 (C-4′), 141.52 (C-1), 134.51 (C-1′), 129.39 (C-2′, C-6′), 128.63 (C-3, C-5), 128.54 (C-2, C-6), 128.28 (C-3′, C-5′), 126.21 (C-4), 40.47 (C-α), 30.34 (C-β), 21.76 (C-4′-C̲H 3 ); HR ESI-MS m / z calculated for C 16 H 17 O [M + H] + 225.1274, found [M + H] + 225.1282.…”

Biotransformation of Hydroxychalcones as a Method of Obtaining Novel and Unpredictable Products Using Whole Cells of Bacteria

“…However, neohesperidin dihydrochalcone is a non-cariogenic, intensive and hypocaloric sweetener permitted by the EU and the FDA as a food additive [8,9]. Chemical hydrogenation of a double bond usually requires reagents containing transition metals, e.g., ruthenium or iridium complex [10,11], which are relatively expensive. Biotransformation is an alternative method to obtain chalcone derivatives without harmful compounds.…”

“…Biotransformation is an alternative method to obtain chalcone derivatives without harmful compounds. Biocatalysis is often described as a part of green chemistry because it is generally conducted under mild and safe Chemical hydrogenation of a double bond usually requires reagents containing transition metals, e.g., ruthenium or iridium complex [10,11], which are relatively expensive. Biotransformation is an alternative method to obtain chalcone derivatives without harmful compounds.…”

Choline Chloride-Based Deep Eutectic Systems in Sequential Friedländer Reaction and Palladium-Catalyzed sp3 CH Functionalization of Methyl Ketones

“…Recently, Wang, Gülcemal, and co-workers have demonstrated application of iridium complexes in sp 3 C–H functionalization utilizing t -amyl alcohol and toluene as a solvent, though at high temperatures 11−13 Likewise, Du and co-workers utilized RhCl(CO)(PPh 3 ) 2 and 1,4-dioxane solvent systems, 14 and other researchers utilized different volatile organic solvents and transition metals such as Fe, Co, and Pd. 15−18 In the above strategy, phosphines (as a P-donor ligand) were fundamental in stabilizing the active low-oxidation states.…”