rhBMP‐2 significantly enhances guided bone regeneration

Wikesjö, Ulf M.E.; Qahash, Mohammed; Thomson, Robert C.; Cook, Alonzo D.; Rohrer, Michael D.; Wozney, John M.; Hardwick, W. Ross

doi:10.1111/j.1600-0501.2004.00971.x

Cited by 112 publications

(142 citation statements)

References 41 publications

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“…This may be attributed to the effects of rhBMP-2 not only on early corticalization of the SM, but also on new bone formation in the peri-implant area. Several studies have found that rhBMP-2 contributed to new bone formation around the implant, thereby supporting the proposal that rhBMP-2 plays such a role [20][21][22]. Therefore, a higher concentration and dosage of rhBMP-2 may be needed in order to achieve results similar to those reported in the previous study.…”

Section: Discussionsupporting

confidence: 62%

Sinus augmentation using rhBMP-2-loaded synthetic bone substitute with simultaneous implant placement in rabbits

Joo

Cha

Lim

et al. 2017

J Periodontal Implant Sci

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Purpose: The aim of this study was to determine the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2)-loaded synthetic bone substitute on implants that were simultaneously placed with sinus augmentation in rabbits. Methods: In this study, a circular access window was prepared in the maxillary sinus of rabbits (n=5) for a bone graft around an implant (Ø 3×6 mm) that was simultaneously placed anterior to the window. Synthetic bone substitute loaded with rhBMP-2 was placed on one side of the sinus to form the experimental group, and saline-soaked synthetic bone substitute was placed on the other side of the sinus to form the control group. After 4 weeks, sections were obtained for analysis by micro-computed tomography and histology. Results: Volumetric analysis showed that the median amount of newly formed bone was significantly greater in the BMP group than in the control group (51.6 mm 3 and 46.6 mm 3 , respectively; P=0.019). In the histometric analysis, the osseointegration height was also significantly greater in the BMP group at the medial surface of the implant (5.2 mm and 4.3 mm, respectively; P=0.037). Conclusions: In conclusion, an implant simultaneously placed with sinus augmentation using rhBMP-2-loaded synthetic bone substitute can be successfully osseointegrated, even when only a limited bone height is available during the early stage of healing.

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Section: Discussionsupporting

confidence: 62%

Sinus augmentation using rhBMP-2-loaded synthetic bone substitute with simultaneous implant placement in rabbits

Joo

Cha

Lim

et al. 2017

J Periodontal Implant Sci

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“…Since periodontal tissue defects typically remain unhealed and often lead to further tissue degeneration and the loss of teeth, understanding the physiological role of these proteins in the wound-healing cascade and tissue regeneration is of critical importance in advancing the treatment of periodontal tissue loss and in enhancing periodontal tissue regeneration. Most of the research in this field has centered on examining the therapeutic effects that these molecules have on hard or soft tissues with the presence of 1 or more growth factors [9][10][11][12][13][14][15][16] . However, as the fields of tissue engineering and biomaterials merge with molecular and cellular biology, new drug delivery vehicles can be utilized to study the in vivo effect of these molecules on periodontal tissue regeneration or periodontal defect repair.…”

Section: Introductionmentioning

confidence: 99%

Preparation of recombinant human bone morphogenetic protein-2 loaded dextran-based microspheres and their characteristics1

Chen

Wang

et al. 2005

Acta Pharmacologica Sinica

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Aim: To prepare new pharmaceutical forms with sustained delivery properties of recombinant human bone morphogenetic protein-2 (rhBMP 2 ) for tissue engineering and guided tissue regeneration (GTR) use. Methods: rhBMP 2 -loaded dextranbased hydrogel microspheres (rhBMP 2 -MPs), which aimed to keep rhBMP 2 bioactivity and to achieve long-term sustained release of rhBMP 2 , were prepared by double-phase emulsified condensation polymerization. The physical, chemical performances and biological characteristics of those microspheres were studied both in vitro and in vivo. Results: The microspheres' average diameter was 30.33±4.32 µm with 75.4% ranging from 20 µm to 40 µm and the drug loading and encapsulation efficiency were 7.82% and 82.25%, respectively. The rhBMP 2 -releasing profiles in vitro showed that rhBMP 2 release could be maintained more than 10 d. The rhBMP 2 -MPs, with good swelling and biodegradation behavior, could be kept for 6 months at below 4 ºC without significant characteristic change or bioactivity loss. Cytology studies showed that rhBMP 2 -MPs could promote the proliferation of periodontal ligament cells (PDLCs) approximately 10 d, while the bioactivity of concentrated rhBMP 2 solution could keep no more than 3 d. Scanning electron microscope showed that rhBMP 2 -MPs could be enchased into the porous structure of calcium phosphate ceremic (CPC) and the eugonic growth of PDLCs in CPC/rhBMP 2 -MPs scaffolds. Animal experiments indicated that using CPC/rhBMP 2 -MPs scaffolds could gain more periodontal tissue regeneration than using rhBMP 2 compound firsthand with CPC (CPC/rhBMP 2 ). Conclusion: By encapsulating rhBMP 2 into dextran-based microspheres, a small quantity of rhBMP 2 could achieve equivalent effects to the concentrated rhBMP 2 solution and at the same time, could prolong rhBMP 2 retention both in vitro and in vivo.

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“…This may be due to a sustained delivery profile or a higher stability of the growth factor (103,141). Overall, loading implants with growth factors has shown to accelerate bone formation (129,131,142,143) and to facilitate the bridging of small gaps between implant and surrounding bone (130,144,145). In summary, coating implants with locally acting growth factors can improve the remodelling process at the tissue-implant interface, and is therefore a promising option for establishing an improved integration of implants into healing bone.…”

Section: Growth Factor Immobilizationmentioning

confidence: 99%

Organic–Inorganic Surface Modifications for Titanium Implant Surfaces

et al. 2008

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Abstract. This paper reviews current physicochemical and biochemical coating techniques that are investigated to enhance bone regeneration at the interface of titanium implant materials. By applying coatings onto titanium surfaces that mimic the organic and inorganic components of living bone tissue, a physiological transition between the non-physiological titanium surface and surrounding bone tissue can be established. In this way, the coated titanium implants stimulate bone formation from the implant surface, thereby enhancing early and strong fixation of bone-substituting implants. As such, a continuous transition from bone tissue to implant surface is induced. This review presents an overview of various techniques that can be used to this end, and that are inspired by either inorganic (calcium phosphate) or organic (extracellular matrix components, growth factors, enzymes, etc.) components of natural bone tissue. The combination, however, of both organic and inorganic constituents is expected to result into truly bone-resembling coatings, and as such to a new generation of surface-modified titanium implants with improved functionality and biological efficacy.

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rhBMP‐2 significantly enhances guided bone regeneration

Abstract: rhBMP-2/ACS significantly enhances GBR at turned and surface-etched dental implants. The dental implant surface technology does not appear to substantially influence bone formation.

Cited by 112 publications

References 41 publications

Sinus augmentation using rhBMP-2-loaded synthetic bone substitute with simultaneous implant placement in rabbits

Sinus augmentation using rhBMP-2-loaded synthetic bone substitute with simultaneous implant placement in rabbits

Preparation of recombinant human bone morphogenetic protein-2 loaded dextran-based microspheres and their characteristics1

Organic–Inorganic Surface Modifications for Titanium Implant Surfaces

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