rhBMP-2 Delivered in a Calcium Phosphate Cement Accelerates Bridging of Critical-Sized Defects in Rabbit Radii

Abstract

RhBMP-2 delivered in a calcium phosphate cement may be useful to achieve bridging of critical-sized defects in patients. Its injectable properties may allow minimally invasive use. Delayed percutaneous administration would also be possible when augmentation is desired following an initial surgical procedure or when soft-tissue injuries preclude adequate initial treatment.

rhBMP-2 Enhances the Bone Healing Response in a Diabetic Rat Segmental Defect Model

“…13,14,[31][32][33][34] In the present study, the rhBMP-2/collagen carrier-treated experimental groups were observed to have significantly increased bridging of the defects and increased radiographic scores and increased histomorphometric and mechanical testing parameters of new bone formation compared with the buffer/collagen-treated group in both DM and non-DM rats.…”

Effect of Escherichia coli-produced recombinant human bone morphogenetic protein 2 on the regeneration of canine segmental ulnar defects

“…Previous studies have shown that CHO-BMP-2 can successfully be used to treat various sizes of bone defect in both rabbits and dogs (Table 2) [9,[11][12][13]. Unfortunately, CHO-BMP-2 can be quite costly.…”

“…According to Sampath et al [7], BMP is a member of the transforming growth factor-b superfamily, and it promotes tissue repair by activating progenitor cell recruitment, proliferation, and differentiation. Many authors have reported that the expression of recombinant human BMP-2 (rhBMP-2) in mammalian [Chinese hamster ovary (CHO)] cells can greatly enhance bone regeneration [5,[8][9][10][11][12][13][14][15][16]. CHO-derived rhBMP is commercially available for the treatment of severe open fractures, long bone non-union, and spinal fusion [17][18][19].…”

Mandibular bone repair by implantation of rhBMP-2 in a slow release carrier of polylactic acid—An experimental study in rats

“…One focus of this regenerative approach is the use of growth factors in skeletal repair that has been extensively researched during the past decade [1]. In particular, bone morphogenic proteins (BMPs) have been successfully applied in the reconstruction of long bones, spine and the facial skeleton in preclinical studies [2][3][4][5][6][7]. The number of materials used as carriers to accomplish delivery of BMPs at the site of implantation is huge and includes mineralized scaffolds [e.g.…”