Rhabdovirus: Rabies

Abrahamian, Fredrick M.; Rupprecht, Charles E.

doi:10.1007/978-1-4939-9544-8_28-2

Cited by 2 publications

(1 citation statement)

References 140 publications

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“…Rabies is a strategic infectious animal disease that affects the central nervous system. The disease is caused by an RNA (ribonucleic acid) highly neurotropic virus in the family Rhabdoviridae, genus Lyssavirus [1]. It is a serious public health problem in developing countries, especially in Asia.…”

Section: Introductionmentioning

confidence: 99%

Anti-rabies in the serum of laying hens after single dose rabies vaccination: An initial observation

Sulaiman N Depamede,

Made Sriasih,

Nurul Azizah

2024

GSC Biol. Pharm. Sci.

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Rabies is a strategic infectious animal disease that attacks the central nervous system. It is a serious public health problem in developing countries, especially in Asia. Approximately 59,000 human deaths occur due to rabies annually. In the addition of vaccines availability, development of practical, accurate and affordable rabies diagnostics is also urgently needed. One of them is immunological-based assay, such as ELISA and lateral flow assay, which requires the readiness of rabies antibodies. Recently, IgY produced from laying hens is quite promising. In this study, before producing rabies IgY, we observed the immune response in laying hens that received a single vaccination dose of rabies vaccine. The results of analysis using in-house ELISA showed the presence of antibodies to the rabies vaccine. Whether the antibodies obtained can be used for diagnostic development still needs to be elucidated since the data available in this study is still limited.

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Section: Introductionmentioning

confidence: 99%

Anti-rabies in the serum of laying hens after single dose rabies vaccination: An initial observation

Sulaiman N Depamede,

Made Sriasih,

Nurul Azizah

2024

GSC Biol. Pharm. Sci.

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Difficulties in diagnosing rabies using the example of a clinical case in the Omsk region

Puzyreva,

Poleshchuk,

Bardina

et al. 2024

Epidemiology and Infectious Diseases

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Rabies is the deadliest zoonotic disease caused by the rabies virus, a member of the genus Lyssavirus. The disease occurs after a bite from a wild or domestic animal.The team of authors presents a clinical case of rabies with the difficulties of early diagnosis of the disease in a patient suffering from alcoholism, features of clinical, epidemiological and laboratory diagnostics. The victim sought medical help 20 days after the dog bite. On day 20, a hydrophobia clinic was observed. Signs of visual and auditory hallucinations, aggressiveness, and disorientation in place and time appeared, which resembled the development of alcoholic psychosis. When testing saliva samples collected on the 3rd day of the disease with PCR for the rabies virus, a negative result was obtained. On the 29th day, the patient died. The diagnosis of rabies was confirmed antemortem and posthumously. The virus was detected in saliva on the 9th day of the disease and posthumously in the cerebral cortex, medulla oblongata, cerebellum, and salivary glands. Histologically, Bebesh-Negri bodies were found in the brain tissue. The necessary preventive measures were carried out in full.The unfavorable outcome in the described case of rabies emphasizes the lack of awareness of the population (especially rural) about the risk of contracting rabies infection through contact with animals and the importance of timely post-exposure prophylaxis. Timely anti-rabies care remains the only effective means of preventing deaths from this disease.

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Rhabdovirus: Rabies

Cited by 2 publications

References 140 publications

Anti-rabies in the serum of laying hens after single dose rabies vaccination: An initial observation

Anti-rabies in the serum of laying hens after single dose rabies vaccination: An initial observation

Difficulties in diagnosing rabies using the example of a clinical case in the Omsk region

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