Rhabdovirus Membrane and Maturation

Low-pH induced conformational changes in viral fusion proteins: implications for the fusion mechanism

“…This m a y be due to a smaller radius of curvature o f the m e m b r a n e at this viral pole or to interaction between the m a t r i x protein and the inner leaflet o f the viral m e m b r a n e at this site (Barge et al, 1993). It is likely that the inner leaflet of the viral m e m b r a n e at this position is enriched in negatively charged phospholipids (Pal & Wagner, 1987) which may have an influence on membrane fusion. It could be that polarized fusion is important for efficient delivery of the nucleocapsid into the cytoplasm.…”

Actin-independent maturation of rabies virus in neuronal cultures

“…The assembly and maturation of rabies virus is believed to be similar to that of other members of the Rhabdoviridae, particularly vesicular stomatitis virus (VSV) (Pal & Wagner, 1987). However, despite advances in the understanding of the intracellular process of virus assembly, the precise mechanism that initiates the outfolding of a patch of modified cellular membrane containing viral protein is not fully understood.…”

Monoclonal Antibody #3‐9‐16 Recognizes One of the Two Isoforms of Rabies Virus Matrix Protein That Exposes Its N‐Terminus on the Virion Surface

“…The M protein of vesicular stomatitis virus (VSV), another major member of the Rhabdoviridae, was extensively studied, and is now known to work multifunctionally in the virus replication cycle, such as the regulation of viral RNA synthesis, stabilization of viral glycoprotein and virion formation with G and RNP at the budding site (1,2,4,15,(19)(20)(21).…”