Rhabdomyosarcoma of the paranasal sinuses in an adult

Koenigsberg, Robert A.; Noah, Ralph; Turtz, Alan; Goldman, Warren; Holland, R; Nicosia, Roberto F.; Lesser, Ray

doi:10.1016/0899-7071(94)00066-l

Cited by 11 publications

(3 citation statements)

References 6 publications

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“…3,4,6,10 In the literature, however, individual case reports are more frequent. [11][12][13] The present work reports on our experience in the treatment of RMS of the nose and paranasal sinuses in 15 patients. Results of treatment, prognostic factors, and the biological behavior of these tumors shall be elucidated.…”

Section: Therapy Protocolsmentioning

confidence: 99%

Rhabdomyosarcomas of the Nose and Paranasal Sinuses: Treatment Results in 15 Cases

Wurm

Constantinidis

Grabenbauer

et al. 2005

Otolaryngol.--head neck surg.

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Section: Therapy Protocolsmentioning

confidence: 99%

Rhabdomyosarcomas of the Nose and Paranasal Sinuses: Treatment Results in 15 Cases

Wurm

Constantinidis

Grabenbauer

et al. 2005

Otolaryngol.--head neck surg.

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“…It is important that RMS tumors are distinguished from the more common tumors of the head and neck occurring in adults, including nasopharyngeal carcinoma, lymphoma, neuroendocrine carcinoma, melanoma, poorly differentiated carcinoma, and metastatic tumor 10,17. Differential diagnosis depends on imaging techniques in combination with histological and immunohistological analysis.…”

Section: Discussionmentioning

confidence: 99%

A Case of Alveolar Rhabdomyosarcoma of the Ethmoid Sinus Invading the Orbit in an Adult

Moon

Kwon

Lee

2006

Korean J Ophthalmol

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PurposeA case study and literature review of alveolar rhabdomyosarcoma (RMS) in an adult.MethodsA 48-year-old male patient presented at our clinic complaining of proptosis that had persisted for 2 weeks in his left eye. A computed tomography (CT) scan revealed a destructive soft-tissue mass in the left ethmoid sinus with invasion of the left orbit and compression of the medial rectus muscle. Endoscopic intranasal biopsy revealed alveolar RMS. Conservative debulking and orbital wall decompression were performed.ResultsImmunohistochemical testing was positive for desmin, S-100, and smooth muscle actin (SMA), supporting the diagnosis of RMS. Since ipsilateral cervical and spinal metastasis was detected, systemic treatment was administered simultaneously.ConclusionsAlthough rarely found in adults, RMS should be considered in the differential diagnosis of orbital tumors. Immunohistochemical analysis plays an important role in the definitive diagnosis of RMS.

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“…4 Parameningeal RMSs have been rarely reported in adults, particularly young adults. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] We report 13 adult patients, ranging in age from 18 to 86 years, with RMS involving parameningeal sites, predominantly the sinonasal cavity.…”

Section: Embryonal and Alveolar Rhabdomyosarcoma Of Parameningeal Sites In Adults: A Report Of 13 Casesmentioning

confidence: 99%

Embryonal and Alveolar Rhabdomyosarcoma of Parameningeal Sites in Adults: A Report of 13 Cases

et al. 2008

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This study reports 13 adult parameningeal rhabdomyosarcomas. Ages ranged from 18 to 86 years. Nine lesions were alveolar, 3 were embryonal, and 1 could not be further classified. All cases were positive for desmin and/or myogenin and 1 tumor was strongly positive for cytokeratin. PAX3-FKHR or PAX7-FKHR fusion transcripts or FKHR breaks were identified in 5 cases confirming a diagnosis of alveolar rhabdomyosarcoma. Three cases were negative supporting a diagnosis of embryonal rhabdomyosarcoma. A total of 10 patients were treated with chemotherapy and radiation. Three patients are alive with no disease, 3 are alive with disease, 3 died of disease, and 4 patients are lost to follow-up. Adult sinonasal rhabdomyosarcoma is uncommon and should be considered in the differential of sinonasal neoplasms. Disease can occur in the elderly. Desmin and myogenin can aid in the diagnosis but cytokeratin reactivity can be seen and care must be taken not to diagnose carcinoma.

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Rhabdomyosarcoma of the paranasal sinuses in an adult

Cited by 11 publications

References 6 publications

Rhabdomyosarcomas of the Nose and Paranasal Sinuses: Treatment Results in 15 Cases

Rhabdomyosarcomas of the Nose and Paranasal Sinuses: Treatment Results in 15 Cases

A Case of Alveolar Rhabdomyosarcoma of the Ethmoid Sinus Invading the Orbit in an Adult

Embryonal and Alveolar Rhabdomyosarcoma of Parameningeal Sites in Adults: A Report of 13 Cases

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