Rhabdomyosarcoma of the genital tract in an 18-month-old girl

ALSaleh, Nourah; ALwadie, Hadeel; Gari, Abdulrahim

doi:10.1093/jscr/rjx080

Cited by 7 publications

(3 citation statements)

References 9 publications

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“…This was proved as BRMS involving the uterus, cervix, and vagina. [ 10 ] Another 10-year-old girl with a history of cystic nephroma treated in infancy, presented with vaginal bleeding of 3 weeks. She was found to have a uterine mass, which histopathologically was BRMS.…”

Section: Discussionmentioning

confidence: 99%

Hemoperitoneum due to ruptured botryoid sarcoma of the uterus in young girl

Rajendran

Ali

Ghalib

et al. 2021

J Indian Assoc Pediatr Surg

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Five-year-old girl presented with lower abdominal pain, pelvi-abdominal mass, and generalized abdominal tenderness. Ultrasound and computed tomography scans diagnosed heterogeneous pelvi-abdominal soft-tissue mass and a large amount of free peritoneal fluid. Laparotomy revealed hemoperitoneum and ruptured tumor at the posterior uterine wall. Histopathology report was botryoid rhabdomyosarcoma (BRMS). This case is unique due to ruptured BRMS of the uterus in early childhood, with no vaginal bleeding.

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Section: Discussionmentioning

confidence: 99%

Hemoperitoneum due to ruptured botryoid sarcoma of the uterus in young girl

Rajendran

Ali

Ghalib

et al. 2021

J Indian Assoc Pediatr Surg

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“…Since 1959, 7 cases of cervical ERMS in infants have been reported, including our patients [2,17–20]. From 6 previous reported cases, 2 of which were cases of recurrent ERMS, the earlier recurrent case was treated with chemotherapy and brachytherapy, while the later one was treated with surgery and chemotherapy [2,19].…”

Section: Discussionmentioning

confidence: 99%

Recurrent Cervical Sarcoma Botryoides in a 3-Year-Old Female: Approach in a Limited Resource Setting

et al. 2019

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Patient: Female, 3 Final Diagnosis: Recurrent sarcoma botryoides Symptoms: Vaginal mass Medication: — Clinical Procedure: Surgical resection • adjuvant chemotherapy Specialty: Obstetrics and Gynecology Objective: Unusual setting of medical care Background: Sarcoma botryoides, known as embryonal rhabdomyosarcoma (ERMS), is a malignant tumor which arises from embryonic muscle cells. The incidence of ERMS in the uterine cervix rarely occurs at a very young age. With sufficient resources, management of this disease is not difficult. However, in limited resources settings, such as in Indonesia, the situation is more challenging. This case report aims to highlight the difficulties encountered in diagnosing and treating patients with sarcoma botryoides. Case Report: A 3-year-old female patient came the outpatient clinic of our hospital with a protruding mass from her vagina resembling a bunch of grapes which easily bled. She underwent surgery to remove the mass. After the procedure, she did not return to the hospital for the recommended adjuvant chemotherapy treatment due to limited funds. Three months later, she came to the outpatient clinic with the same complaint, despite smaller size. Due to limited resources, we only evaluated the metastasis using chest x-ray and did not perform intra-operative biopsy. In the second surgery, a wide excision with 1–2 cm margin was performed, followed by adjuvant chemotherapy for 6 series. We achieved a satisfactory outcome in this case, and 18 months after the surgery, the patient was still in remission. Conclusions: Sarcoma botryoides is a rare malignancy. The effective treatment for sarcoma botryoides is wide excision with safe margin of 1–2 cm, followed by 6–12 cycles of vincristine, actinomycin D, and cyclophosphamide (VAC) regiment as an adjuvant chemotherapy. A family’s understanding of the treatment plan is important to achieve desired outcomes. Even with limited resources, this malignancy can still be properly treated.

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“…Characteristics and treatment of female patients with botryoid sarcoma[18,25,[27][28][29][30][31][32][33][34][35][36].…”

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Sarcoma Botryoides: Optimal Therapeutic Management and Prognosis of an Unfavorable Malignant Neoplasm of Female Children

et al. 2023

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Embryonal rhabdomyosarcoma (ERMS) is a rare malignancy and occurs primarily in the first two decades of life. Botryoid rhabdomyosarcoma is an aggressive subtype of ERMS that often manifests in the genital tract of female infants and children. Due to its rarity, the optimal treatment approach has been a matter of debate. We conducted a search in the PubMed database and supplemented it with a manual search to retrieve additional papers eligible for inclusion. We retrieved 13 case reports and case series, from which we summarized that the current trend is to approach each patient with a personalized treatment plan. This consists of a combination of local debulking surgery and adjuvant or neoadjuvant chemotherapy (NACT). Effort is made in every approach to avoid radiation for the sake of preserving fertility. Radical surgeries and radiation still have a role to play in extensive disease and in cases of relapse. Despite the rarity and aggressiveness of this tumor, disease-free survival and overall prognosis is excellent, especially when it is diagnosed early, compared with other subtypes of rhabdomyosarcoma (RMS). We conclude that the practice of a multidisciplinary approach is appropriate, with favorable outcomes; however, larger-scale studies need to be organized to have a definite consensus on optimal management.

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Rhabdomyosarcoma of the genital tract in an 18-month-old girl

Cited by 7 publications

References 9 publications

Hemoperitoneum due to ruptured botryoid sarcoma of the uterus in young girl

Hemoperitoneum due to ruptured botryoid sarcoma of the uterus in young girl

Recurrent Cervical Sarcoma Botryoides in a 3-Year-Old Female: Approach in a Limited Resource Setting

Sarcoma Botryoides: Optimal Therapeutic Management and Prognosis of an Unfavorable Malignant Neoplasm of Female Children

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