Rhabdomyosarcoma of the corpus uteri

Donkers, B.; Kazzaz, B. A.; Meijering, J.H.

doi:10.1016/0002-9378(72)90863-0

Cited by 26 publications

(4 citation statements)

References 10 publications

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“…Rhabdomyosarcomas of the uterus in man can occur either as a constituent of malignant mixed mullerian tumors or as pure rhabdomyosarcomas. The latter tumor type is rare (3,7) and occurs predominantly in children (8, 9). The only case of rhabdomyosarcoma of the uterus in animals has been reported in a one-year-old quarter horse filly (1 1 in man is still uncertain.…”

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“…Necropsy revealed uterine neoplasms that ranged between 5 mm and 50 mm in diameter. Three neoplasms (cases [2][3][4] were located in the right horn, 2 in the left horn (cases 5 and 6) and one (case 1) at the bifurcation of the uterus. With one exception, the neoplasms had completely distorted the 6utlines of the uterine horns affected and caused displacement of adjacent organs like intestine, ovaries and bladder.…”

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Spontaneous Malignant Mixed Müllerian Tumors and Rhabdomyosarcoma of the Uterus in Rats

Kaspareit-Rittinghausen¹,

Deerberg²

1990

Toxicol Pathol

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Five malignant miied miillerian tumors and one rhabdomyosarcoma were observed in LEWIS rats. Heterologous mullerian neoplasms (cases 1 4 ) consisted of epithelial and mesenchymal elements including squamous epithelium, glandular epithelium and sarcomatous, rhabdomyosarcomatous, cartilaginous as well as OSS~OUS parts. All the heterologous tumors revealed undifferentiated areas with an anaplastic appearance. The homologous miillenan tumor (case 5 ) was composed of glandular epithelium embedded in sarcomatous tissue. The rhabdomyosarcoma (case 6) consisted of bundles of elongated strap-like cells mixed with cells resembling rhabdomyoblasts.Keywords. Uterus tumors; mixed mesodermal tumors; carcinosarcoma; embryonal rhabdomyosarcoma; histopathology; LEWIS rats Malignant mixed mullerian tumors are characterized by an admixture of malignant epithelial and mesenchymal elements. If the stromal component is an undifferentiated sarcoma, the neoplasm is designated as homologous. Heterologous mixed mullerian tumors are those that also contain chondrosarcomatous, osteosarcomatous and/or rhabdomyosarcomatous parts (5). This distinction between types was emphasized in the past by the,use of different terms: carcinosarcoma for homologous tumors and mixed mesodermal tumor for heterologous neoplasms (1). The occurrence of malignant mixed mullerian tumors in man is well documented (2, 6, 12), while the tumors have not been observed in domestic or laboratory animals up to now. Rhabdomyosarcomas of the uterus in man can occur either as a constituent of malignant mixed mullerian tumors or as pure rhabdomyosarcomas. The latter tumor type is rare (3,7) and occurs predominantly in children (8, 9). The only case of rhabdomyosarcoma of the uterus in animals has been reported in a one-year-old quarter horse filly (1 1). The histogenesis of mixed mullerian tumors and uterine rhabdomyosarcomas in man is still uncertain. An origin from either pluripotent persisting remnants of the primitive mesoderm of mullerian ducts (7, 10) or from metaplasia (3, 7) of endometrial stroma have been mainly discussed. In the present report, we describe the histopathological features of heterologous (cases 1-4) and homologous (case 5 ) malignant mixed mullerian tumors as well as of an uterine rhabdomyosarcoma (case 6). To our knowledge, there are no doc-* umented reports of these uterine tumor types in rats or other laboratory animals. The tumor-bearing rats belonged to a colony of LEW/Han rats (300 males, 300 females) kept in a longevity-study from weaning to their natural death. They were housed in groups of 5 (separated according to sex) in polycarbonate cages in an animal room at 22 f 1°C room temperature, 55 f 5% relative humidity, 15 mm H20 atmospheric pressure, with a 12: 12 hr light-dark sequence and an air exchange rate of 20 times per hr. All rats were fed an autoclaved, cereal-based diet ad libittiin. Acidified and pasteurized tap water was continually available. The breeding colony of LEWIS rats is examined routinely and the rats arc known to...

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confidence: 99%

Spontaneous Malignant Mixed Müllerian Tumors and Rhabdomyosarcoma of the Uterus in Rats

Kaspareit-Rittinghausen¹,

Deerberg²

1990

Toxicol Pathol

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“…However, currently it is considered a variant of the so-called mixed mesodermal tumors of the uterus. 3 Uterine corpus RMS can arise as part of a biphasic uterine tumor (adenosarcoma or carcinosarcoma) or as a separate heterologous tumor. 4 Adult patients with pure uterine RMS are uncommon and difficult to diagnose.…”

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confidence: 99%

“…Previously, this pure heterotopic tumor of the uterine corpus was classified as a separate entity. However, currently it is considered a variant of the so‐called mixed mesodermal tumors of the uterus 3 . Uterine corpus RMS can arise as part of a biphasic uterine tumor (adenosarcoma or carcinosarcoma) or as a separate heterologous tumor 4 .…”

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confidence: 99%

Management of a pure uterine corpus rhabdomyosarcoma in a postmenopausal patient: A rare case report and review of the literature

Lugata,

Smith,

Mrosso

et al. 2024

Clinical Case Reports

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Key Clinical MessageRhabdomyosarcoma of the female genital tract often involves the vagina and cervix. It usually occurs in infants and children. Such tumors are uncommon in the uterus, especially in adults. Treatment options are based on studies of younger individuals.AbstractRhabdomyosarcoma (RMS) is a malignant mesenchymal neoplasm with a tendency to differentiate into skeletal muscle cells. RMS is an aggressive tumor that tends to develop in children and younger patients. A vast majority of genital tract RMSs occur in the vagina and cervix. Such tumors rarely occur in adults. Usually, these tumors either occur as a component of a biphasic uterine tumor (carcinosarcoma or adenosarcoma) or can be a pure heterologous tumor. Pure uterine RMSs are extremely rare in adult patients and difficult to diagnose. Accurate diagnosis of these tumors depends on precise histopathological evaluation. The present report describes a rare case of embryonal RMS of the uterus in a postmenopausal female and explores the most recent literature. The aim is to strengthen the existing literature and aid clinicians in the management of similar cases. A 64‐year‐old postmenopausal female presented with a history of abdominal pain associated with abdominal distension, per vaginal bleeding, and foul‐smelling discharge for 6 months. A transabdominal ultrasound revealed a bulky uterus with a well‐circumscribed heterogeneous lesion. Histopathology confirmed the diagnosis of high‐grade embryonal RMS within the corpus region of the uterus. A total abdominal hysterectomy with bilateral salpingo‐oophorectomy was performed, followed by adjuvant chemotherapy to prevent relapse of the disease. Six months after oncological care has passed, the patient remains symptoms‐free without evidence of recurrence or metastasis.

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Pure Alveolar Rhabdomyosarcoma of the Corpus Uteri: Description of a Case with Increased Serum Level of CA-125

Chiarle¹,

Godio²,

Fusi³

et al. 1997

Gynecologic Oncology

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Rhabdomyosarcoma of the corpus uteri

Cited by 26 publications

References 10 publications

Spontaneous Malignant Mixed Müllerian Tumors and Rhabdomyosarcoma of the Uterus in Rats

Spontaneous Malignant Mixed Müllerian Tumors and Rhabdomyosarcoma of the Uterus in Rats

Management of a pure uterine corpus rhabdomyosarcoma in a postmenopausal patient: A rare case report and review of the literature

Pure Alveolar Rhabdomyosarcoma of the Corpus Uteri: Description of a Case with Increased Serum Level of CA-125

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