Rhabdomyosarcoma of the Adult Nasopharynx

Kanagalingam, Jeevendra; Medcalf, M; Courtauld, E.; Clarke, Peter

doi:10.1159/000058032

Cited by 8 publications

(8 citation statements)

References 10 publications

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“…18 Alveolar rhabdomyosarcoma is also the predominant RMS type in the nasopharynx. 14 Our results, however, contrast with those of others who identified higher percentage of ERMS and mixed alveolar and embryonal patterns. In a review of 37 adults and children with sinonasal RMS, 16 cases were embryonal, 15 alveolar, 1 mixed, and 5 were unclassified.…”

Section: Discussioncontrasting

confidence: 99%

“…The clearing of the cytoplasm is most likely due to the presence of glycogen and/or lipid 5 and has been observed in previous reports of sinonasal RMS. [14][15][16][17] The clearing of the cytoplasm, even though it might not bear any known clinical significance, can add to the diagnostic confusion. Clear cells were also seen in RMS of other head and neck areas.…”

Section: Discussionmentioning

confidence: 99%

“…Our results are in agreement with other previously published studies of sinonasal RMS, which showed that ARMS is the predominant histologic pattern. 14,18,19 In a study of 12 cases of head and neck RMS, 3 of 4 sinonasal tumors had alveolar histology. 18 Alveolar rhabdomyosarcoma is also the predominant RMS type in the nasopharynx.…”

Section: Discussionmentioning

confidence: 99%

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Sinonasal Rhabdomyosarcoma in Children and Young Adults

Ahmed

Tsokos

2007

Int J Surg Pathol

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Rhabdomyosarcoma is an aggressive malignant tumor often developing in the head and neck in children. In the sinonasal region, rhabdomyosarcoma constitutes a clinically important group because of the difficulty of surgical resection and its generally poor prognosis. We reviewed the archival pathology materials of 39 cases of rhabdomyosarcoma of the head and neck in children and young adults. The diagnosis was made through light microscopy, immunohistochemistry, electron microscopy, and/or reverse-transcriptase polymerase chain reaction (RT-PCR) molecular testing. We identified 14 tumors in the nose and paranasal sinuses. Patients' ages ranged from 9 to 40 years. Thirteen of the tumors were of the alveolar subtype. In 11 cases, the tumor cells were poorly differentiated, forming a solid alveolar pattern. In 2 cases, there was evidence of rhabdomyoblastic differentiation. Only one case was classified as embryonal rhabdomyosarcoma. A significant number of tumor cells in these cases had clear or vacuolated cytoplasm. Four alveolar rhabdomyosarcoma tumors were tested by RT-PCR; all showed PAX3/FKHR chromosomal translocation. We conclude that sinonasal rhabdomyosarcoma is predominantly of the alveolar subtype and frequently shows clear cells. A review of the literature shows that these tumors carry a poor prognosis, partly because of their parameningeal location and partly because of their "undifferentiated" alveolar histology.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Sinonasal Rhabdomyosarcoma in Children and Young Adults

Ahmed

Tsokos

2007

Int J Surg Pathol

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“…17,18 This is not surprising since this is a rare tumor in the nasopharynx especially in the adult. 7 The cancers of the nasopharynx present with varying clinical features with majority being vague and nonspecific in early stage. The commonest clinical symptom in the present study was neck swelling which represents lymphadenopathy, a similar finding by several other researchers.…”

Section: Discussionmentioning

confidence: 99%

“…5,6 It is rare especially after 40years and the commonly found type in the adult nasopharynx is the alveolar variant. 7 Other malignancies such as adenocarcinomas often from salivary glands are rarely seen as primary malignant tumor of the nasopharynx. Nasopharyngeal carcinoma (NPC) by far is the commonest primary malignancy seen in the nasopharynx.…”

Section: Introductionmentioning

confidence: 99%

Nasopharyngeal cancers in University of Port Harcourt teaching hospital: a five year review

Uju

2020

Int J Otorhinolaryngol Head Neck Surg

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Background: Nasopharyngeal cancer though an uncommon head and neck cancer, has high morbidity and mortality. It is a cancer that has peculiar geographic variations and hence has been studied by a lot of researchers globally. It however has not been studied as an entity in the South region. This study was to determine the clinical and histologic presentations as well as the prevalence of this disease in Port Harcourt.Methods: Hospital based retrospective review of all patients with confirmed diagnosis of nasopharyngeal cancer seen within the period of January 2014 to December 2018 at ENT Department University of Port Harcourt teaching hospital. The hospital records were the source of data. The demographics, clinical presentations, histology, investigations and outcome were all collated from the records and were analyzed with IBM SPSS version 25. Results: Forty-one patients were studied with age range of 12-85 years. The mean age was 43±15.1 years. Male to female ratio was 1.2:1. Age 40 to 49 years was the most affected. Nasopharyngeal carcinoma was the commonest cancer recorded 68.29% followed by non-Hodgkin’s lymphoma 19.5%. Keratinizing squamous cell carcinoma was the commonest histologic type 43.9%. Commonest symptoms were neck swelling and nasal congestion 24.55%. Age distribution showed a statistical difference with histology of cancer. Mortality of 4.87 was recorded; the rest was lost to follow up.Conclusions: Nasopharyngeal carcinoma is the commonest cancer in the nasopharynx. It is significantly related with age. Patients often present late and it has very high morbidity and mortality rate. Attention to early vague symptoms will enhance early diagnosis, treatment therefore prognosis.

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