Rhabdomyosarcoma of Cervix: A Case Report

Abstract

IntroductionRhabdomyosarcoma has known as a highly malignant soft tissue sarcoma. It has been the most common soft tissue sarcoma in childhood, accounting for about 3 to 4 % of all cases of childhood cancer. Rhabdomyosarcoma was rare in adults, accounting for 3% of all soft-tissue sarcomas. embryonal rhabdomyosarcoma of female genital tract including uterine cervix in an adult was rare.Case PresentationThis study has reported a 33-year-old woman presented with abnormal vaginal discharge. Gynecologic examination revealed a cervical mass with grape- like feature protruding into vagina with posterior- superior vaginal wall involvement. Biopsy has performed and pathologic examination was consistent with embryonal botryoid type rhabdomyosarcoma. She has undergone the staging work up measurements including thoracic computed tomography (CT) scan, abdominopelvic magnetic resonance imaging (MRI), bone scan and bone marrow examination. In exception of abdominopelvic MRI, with 2 suspicious pelvic lymph nodes in addition of cervical mass, all others were normal. Radical hysterectomy with lymph node debulking and ovarian preservation has performed. Final results have shown embryonal botryoid type rhabdomyosarcoma of cervix. ovaries, endometrium, parametrium, and follopian tubes were unremarkable. Pelvic lymph nodes pathology and intraabdominal fluid cytology were negative for malignancy. Lymphovascular invasion was identified. She has advised for adjuvant chemotherapy.ConclusionsThis case has reminded that embryonal rhabdomyosarcoma could occur in uncommon site and older female. Longer follow up of these cases has required due to lack of survival data for embryonal rhabdomyosarcoma of this site and age group.

Embryonic cervical rhabdomyosarcoma complicated with uterine inversion with cerebral venous sinus thrombosis as the first symptom: a case report and literature review

“…Since the first report of a case of cervical rhabdomyosarcoma in a 75-year-old woman in 1971, 24 cases in adults have been reported (Table 1). 15–35 The age ranges from 19 to 75 years. The most common symptoms were vaginal bleeding and swelling.…”

“…Only one case was reported for examination because of abnormal vaginal discharge, which was consistent with the current case. 31 Five patients presented with symptoms of cervical polyps, which usually occurred in sarcoma botryoides, a subtype of embryonal rhabdomyosarcoma, because it arose beneath a mucous membrane. Although the largest diameter of the mass was 10 cm among these cases, 15–35 the current case was 18 cm, indicating that the patient’s condition was progressing rapidly and that her prognosis was poor.…”

“…31 Five patients presented with symptoms of cervical polyps, which usually occurred in sarcoma botryoides, a subtype of embryonal rhabdomyosarcoma, because it arose beneath a mucous membrane. Although the largest diameter of the mass was 10 cm among these cases, 15–35 the current case was 18 cm, indicating that the patient’s condition was progressing rapidly and that her prognosis was poor. The IRS group of most patients was stage I, so the current case was no exception.…”

Cervical rhabdomyosarcoma in an endocervical polyp of a 50 year old patient with intermenstrual bleeding

“…This case highlights the difference in presentation between our patient and the pediatric population. In younger patients the tumor most commonly presents as a cervical mass or polyp, often described as “bunch of grapes” (Hosseini et al, 2016). However, visual inspection of the cervix in our patient revealed no abnormalities.…”

Primary alveolar rhabdomyosarcoma of retrorectal-presacral space in an adult patient

“…[ 2 ] The head and neck are the most frequent sites of origin, followed by the genitourinary tract, extremities, trunk, retroperitoneum, and uncommon regions. [ 3 – 8 ] One of the least common sites for RMS is the retrorectal-presacral space. We present the case of a 51-year-old male with primary alveolar rhabdomyosarcoma (ARMS) of the retrorectal-presacral space, and to our knowledge, it is the first reported case of an ARMS developed in this location.…”