Rhabdomyosarcoma in middle ear of an adult: a rare presentation

Bhargava, Seema; Grover, Mohnish; Mehta, Jayanti; Maheshwari, V D

doi:10.1093/jscr/2012.10.9

Cited by 4 publications

(3 citation statements)

References 4 publications

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“…Studies have suggested that distinct genetic factors are involved in the development and tumour progression of RMS, such as loss of heterozygosity, specific chromosomal translocations, and abnormal gene alterations. [ 9 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 7 ] Immunohistochemistry is required to differentially diagnose it from other small round cell neoplasms, namely lymphoma (CD20, CD3 positive) and Ewing's sarcoma/primitive neuroectodermal tumour (CD99 positive) as RMS is negative for these markers. [ 9 ] The RMS tumour cells express Desmin, Myogenin, CD56, muscle-specific actin, Myoglobin, Vimentin, and MyoD1. The demonstration of foetal haemoglobin in tumour tissue by immunoperoxidase staining has been shown to be reliably accurate in identifying RMS.…”

Section: Discussionmentioning

confidence: 99%

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Embryonal Rhabdomyosarcoma of External Ear - A Rare Case Report

Ravali¹,

Jakkula²,

Gogineni³

et al. 2021

Annals of Maxillofacial Surgery

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The Rationale: Rhabdomyosarcoma (RMS) is an uncommon tumour which presents at a wide variety of different head and neck sites. They are highly aggressive malignant mesenchymatous soft tissue sarcomas. Their occurrence in the outer ear is extremely rare. Patient Concerns: A 17-year-old female patient reported with a chief complaint of steady increase in growth over the left ear since 6 months, which is not associated with pain and ulceration. Diagnosis: Edge biopsy sections of the swelling over the left pinna and immunohistochemistry records of cells show MYODI positive confirming as Embryonal RMS. Treatment: Left auriculectomy and supra-omohyoid neck dissection with level V lymph node was performed. Outcomes: Uneventful postoperative healing in the resected site was elicited in the follow-up period of 1 year with no recurrence. Take-away Lessons: External ear RMS is extremely rare. Careful clinical, radiological and histopathological evaluation are essential for prompt definitive diagnosis and for successful management.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Embryonal Rhabdomyosarcoma of External Ear - A Rare Case Report

Ravali¹,

Jakkula²,

Gogineni³

et al. 2021

Annals of Maxillofacial Surgery

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“…Tissue stains help differentiate RMS from other tumors with similar histopathology, such as lymphomas (CD20+ and CD3 +), and Ewing's Sarcoma (CD 99+). [10] RMS will be positive for multiple muscle markers, the most specific and sensitive marker is the muscle transcription factors MyoD and Myogenin. [11] The standard of treatment for RMS includes excisional surgery, multidrug chemotherapy, and EBRT.…”

Section: Discussionmentioning

confidence: 99%

Rhabdomyosarcoma of the External Ear Canal Treated with Brachytherapy

Qureshi¹,

Farooki²,

O’Suoji³

2016

WVMJ

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Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma. RMS of the ear usually involves the middle ear cavity. Treatment usually involves surgery, multi drug chemotherapy regimen, and high dose external beam radiotherapy (EBRT). We present a case of a 17-month-old Caucasian female with an unusual presentation of RMS localized to her external ear canal only, which was initially believed to be an otitis media. Treatment consisted of a regimen involving brachytherapy as the radiation modality rather than EBRT. The goal of brachytherapy use is to decrease morbidity associated with radiation of the head and vital organs in developing children.

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