Rhabdomyosarcoma in a child with massive pleural effusion: Cytological diagnosis from pleural fluid

Cohen, Isaac; Loberant, Norman; King, Edwin; Herskovits, Miriam; Sweed, Yehiel; Jerushalmi, Jacqueline

doi:10.1002/(sici)1097-0339(199908)21:2<125::aid-dc9>3.0.co;2-z

Cited by 13 publications

(7 citation statements)

References 13 publications

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“…In addition, some cases have shown remarkable cohesion. 2,13,15 We also found that most SRBCTs kept their SRBCT appearance; however, most cases had loosely to tightly cohesive clusters of malignant cells, and a few cases showed a more epithelioid cell morphology because of increased cytoplasm.…”

Section: Sarcomas Involving Body Cavity Fluids/chen Et Almentioning

confidence: 52%

Clinical, cytologic, and immunohistochemical features of sarcomas involving body cavity fluids

Chen

Janko²,

Pitman

et al. 2019

Cancer Cytopathology

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Background Sarcomas are uncommon findings in body cavity fluids. Diagnosis may be challenging because sarcoma cells in fluids can round up and lose their characteristic appearance seen on smears and histologic sections. This study characterizes the cytologic features of sarcomas involving body cavity fluids. Methods Effusion fluids and cerebrospinal fluids diagnosed as positive for sarcoma were reviewed. Results Forty‐three fluids from 28 patients (median age, 47 years) were positive for sarcoma. Four patients who presented with positive fluids were alive at 1 to 10.7 years' follow‐up (median, 22.5 months). Twenty‐four patients died 2 days to 2 years (median, 19 days) after their positive fluid diagnoses. Twenty‐eight specimens from 20 patients had slides available for review. Although 18 of the 28 positive fluids had a morphology comparable to that of their primary, 4 small round blue cell tumors (SRBCTs) and 4 spindle cell tumors showed epithelioid morphology, 1 SRBCT had pleomorphic morphology, and 1 epithelioid primary had SRBCT morphology. Nine fluids had tumor cells in large, cohesive clusters mimicking carcinoma; workup was performed for 10, predominantly to rule out carcinoma and mesothelioma. Conclusions Sarcoma morphology may be altered in exfoliated cytology specimens. Workup on cell blocks aids in the differential diagnosis, especially for carcinoma and mesothelioma. Unsurprisingly, fluid cytology positive for sarcoma portends poor survival.

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Section: Sarcomas Involving Body Cavity Fluids/chen Et Almentioning

confidence: 52%

Clinical, cytologic, and immunohistochemical features of sarcomas involving body cavity fluids

Chen

Janko²,

Pitman

et al. 2019

Cancer Cytopathology

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“…This is probably due to significant tumor neovascularization as evidenced by prominent enhancing vessels within the mass and significant tumor neovascularization as seen intraoperatively. It has been reported that pleural effusion is rare in intrathoracic rhabdomyosarcomas [6]. However, their statistics did not include pleural primaries.…”

Section: Discussionmentioning

confidence: 96%

“…It accounts for 10% of solid tumors in childhood and is the 3rd most common after neuroblastoma and Wilm's tumor [3]. Although the thoracic wall is involved in up to 70% of cases [6], pulmonary, mediastinal and pleural primaries are rare. The first reported case of a rhabdomyosarcoma arising from a pleural membrane documented thickening of the parietal pleura by computed tomography [4].…”

Section: Discussionmentioning

confidence: 99%

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Primary Pleural Rhabdomyosarcoma: Plain Film, CT and MRI Findings of This Extremely Rare Intrathoracic Tumor

Sanchez

Patel²,

Satake³

et al. 2011

OJRad

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Primary pleural rhabdomyosarcoma is an extremely rare intrathoracic malignancy. We present a case of a previously healthy 2-year-old male complaining of cough and shortness of breath. The plain film, CT and MRI descriptions of this pleural tumor are presented. This is a fast growing tumor that is indistinguishable radiographically from other large intrathoracic tumors such as pleuropulmonary blastoma.

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“…Rhabdomyosarcoma presenting in effusion cytology specimens is an uncommon but well described event. [1][2][3][4][5][6][7][8][9][10][11] Typically, the cells of rhabdomyosarcoma present in effusion specimens as dyshesive individual cells with scant cytoplasm which has been described as a small round blue cell tumor. Alveolar rhabdomyosarcoma cases can have more abundant cytoplasm, but typically still resemble a small round blue cell tumor.…”

Section: Introductionmentioning

confidence: 99%

Effusion cytology of epithelioid rhabdomyosarcoma

Renshaw

Gould

2019

Diagnostic Cytopathology

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Rhabdomyosarcoma in a child with massive pleural effusion: Cytological diagnosis from pleural fluid

Cited by 13 publications

References 13 publications

Clinical, cytologic, and immunohistochemical features of sarcomas involving body cavity fluids

Clinical, cytologic, and immunohistochemical features of sarcomas involving body cavity fluids

Primary Pleural Rhabdomyosarcoma: Plain Film, CT and MRI Findings of This Extremely Rare Intrathoracic Tumor

Effusion cytology of epithelioid rhabdomyosarcoma

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