Rhabdomyolysis with severe hypernatremia

Opas, Lawrence; Adler, Robert; Robinson, Ricki; Lieberman, Ellin

doi:10.1016/s0022-3476(77)81233-x

Cited by 26 publications

(10 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regression analysis of the hypertonic saline test results suggests destruction of the osmoreceptor (Robertson, 1983). While it may be argued that the osmotic stimulus was not sufficient to exclude resetting of the osmostat (Gill et al, 1985) it may be noted that the patient demonstrated adipsia despite a plasma sodium of 187 mmol/I and plasma osmolality of 397 mOsm/kg in circumstances producing the syndrome of muscle weakness (Maddy & Winternitz, 1971) and rhabdomyolysis (Opas et al, 1977). Nausea is a potent non-osmotic stimulus to AVP release (Rowe et al, 1979) and a rapid and marked rise in plasma AVP was provoked by the apomorphine test.…”

Section: Discussionmentioning

confidence: 96%

Chronic hypernatraemia and hypothermia following subarachnoid haemorrhage

Nussey

Ang

Jenkins

1986

Postgraduate Medical Journal

View full text Add to dashboard Cite

Summary:We describe a 30 year old man who developed chronic adipsic hypernatraemia and hypothermia following a subarachnoid haemorrhage from an anterior communicating artery aneurysm. Anterior pituitary function tests were normal. Hypothermia was demonstrated over 4 years with loss ofthe ability to control heat conservation despite body temperatures as low as 30°C. He failed to experience thirst despite plasma sodium concentrations of up to 187 nmol/1 and plasma osmolalities of up to 397 mOsm/kg. The slope of the plasma vasopressin-plasma osmolality curve indicated loss of the osmoreceptor. There was an absent vasopressin response to insulin-induced hypoglycaemia but a normal response to apomorphine. The apomorphine-stimulated immunoreactive vasopressin was shown to behave identically to the synthetic peptide on HPLC and was bioactive.

show abstract

Section: Discussionmentioning

confidence: 96%

Chronic hypernatraemia and hypothermia following subarachnoid haemorrhage

Nussey

Ang

Jenkins

1986

Postgraduate Medical Journal

View full text Add to dashboard Cite

show abstract

“…However, ARF is less common in children with rhabdomyolysis, being reported mostly as single cases or as a small series of patients [11,14,15,16,17,18,19,20,21,22,23]. Several conditions provoking rhabdomyolysis and ARF have been reported in children.…”

Section: Discussionmentioning

confidence: 99%

Rhabdomyolysis and acute renal failure in children

Watanabe¹

2001

Pediatric Nephrology

View full text Add to dashboard Cite

Acute renal failure (ARF) is an important complication of rhabdomyolysis. However, the contributing factors to the development of ARF in children with rhabdomyolysis remain obscure. The aim of this study was to clarify the factors contributing to the development of ARF in children with rhabdomyolysis. This is a retrospective review of the clinical characteristics, laboratory data, pediatric risk of mortality (PRISM) scores, the occurrence of systemic inflammatory response syndrome (SIRS) criteria, and the number of dysfunctional organs in 18 children with rhabdomyolysis seen in our hospital between 1991 and 2000. The patients were divided into an ARF group (n=9) and a non-ARF group (n=9). All patients with ARF had more than two dysfunctional organs. The incidence of dehydration, serum concentrations of myoglobin, creatinine kinase, aspartate aminotransferase, and lactate dehydrogenase, PRISM scores, and the numbers of SIRS criteria and dysfunctional organs were higher in the ARF group than the non-ARF group. The blood pH and base excess, and urinary pH were lower in the ARF group than in the non-ARF group. These results suggest that ARF is more likely to develop in the presence of dehydration, metabolic acidosis, or severe muscle damage, or with multiple organ failure in children with acute rhabdomyolysis.

show abstract

“…The response of this patient was excellent; his serum sodium concentration declined to the normal range over 7 days. The specific cause for the muscle lesion was never identified, but this syndrome has been reported pre viously [5][6][7],…”

Section: Importance O F Body Weight In the Differential Diagnosis O Fmentioning

confidence: 99%