Rhabdomyolysis With Risperidone and Escitalopram Coadministration

Abstract

To the Editors: CASE REPORTCombining different drugs is a common clinical practice, also for treating somatic diseases in psychiatric patients. Pharmacodynamic or pharmacokinetic drug-drug interactions can thereby lead to desired effects, attenuated effects, undesired harmful effects or even to serious adverse reactions. Treatment with several drugs enhances the risk of adverse drug reactions and drug-drug interactions. The probability of interactions in-FIGURE 1. Risperidone, 9-OH-RIS and VPA serum levels before, during, and after concomitant medication with meropenem. Serum levels of RIS and 9-OH-RIS in ng/mL, VPA serum-levels in μg/mL. Daily dose of RIS was reduced from 4 mg to 2 mg. Meropenem treatment started at week 4 and ended with week 9.

Escitalopram-associated rhabdomyolysis

“…Rabdomyolyse som bivirkning av lavdose escitalopram i monoterapi ble beskrevet i 2011 (8). Kasuistikker har beskrevet rabdomyolyse som følge av escitalopram eller andre SSRI-preparater, men da etter høyere dosering (9), i kombinasjon med andre legemidler (10,11), etter overdose (12, 13) eller etter hard fysisk aktivitet i kombinasjon med nylig doseøkning (14).…”

Study on the Process of the Reaction Catalyzed by Polyphenol Oxidase from Purple Sweet Potato

“…Consumption of fresh-cut fruits and vegetables increases quickly in recent years because of their freshness, conveniency, nutrition and no-pollution [1]. Enzymatic browning is one of the major factors to cause low nutritive value and exterior quality of fruits and vegetables in their storage and processing [2][3][4].…”