Rhabdomyolysis with acute tubular necrosis following occupational inhalation of thinners

Ngajilo, Dorothy; Ri, Ehrlich

doi:10.1093/occmed/kqx048

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…A timely introduction of renal replacement therapy is needed. Mild transaminitis, which is reversible, has been previously reported in the literature (10,32).…”

Section: Casementioning

confidence: 69%

“…Rhabdomyolysis results either because of direct toluene muscular injury or prolonged immobility. They are usually seen with ingestion of toluene, but is reported in patients with thinner intoxication by inhalation (5,(30)(31)(32). Moreover, electrolyte abnormalities like hypokalemia and hypophosphatemia can also result in rhabdomyolysis and hence AKI.…”

Section: Casementioning

confidence: 99%

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Automobile Paint Reducer Induced Acute Kidney Injury

Latief¹,

Hassan²,

Wani³

et al. 2021

jrenhep

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The various aspects of the automobile industry also carry with it the risk for occupational health hazards with it. Toluene has also evolved as a commonly used drug by substance abusers. Accidental exposure or self-poisoning with these substances has been reported in literature. These substances can also cause distal renal tubular acidosis (RTA), acute tubular necrosis, glomerulonephritis and interstitial nephritis, rhabdomyolysis and myoglobinemia.In this series, we report about three patients who developed renal manifestations because of organic solvents. Two of the three patients had ingested the paint reducer substance and the third one was addicted to sniffing the toluene based paint reducer. All the patients had in taken these substances with suicidal intent and developed acute kidney injury (AKI) and severe metabolic acidosis. One of the patients had features of rhabdomyolysis as well. The third patient was a substance abuser and had inhaled higher than usual dose and developed severe and refractory acidosis and mild kidney injury and required Renal Replacement Therapy (RRT) for acidosis. All the patients eventually recovered their kidney functions and were doing well during their follow-up.Toluene based organic solvents lead to acute neurological symptoms, accompanied by severe metabolic alterations, organ injury and dysfunc-tion. An association of the development of hypokalemic paralysis and metabolic acidosis with toluene intoxication has been observed. The management of acute toluene toxicity is mainly conservative, consisting of electrolytes correction, acid-base and fluid abnormalities and renal replacement therapy in severe AKI.Organic solvent exposure may result in acute tubular necrosis, rhabdomyolysis, RTA and AKI irrespective of the intake route. Clinical suspicion of organ dysfunction and failure and timely induction of supportive care leads to a good outcome.

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“…A timely introduction of renal replacement therapy is needed. Mild transaminitis, which is reversible, has been previously reported in the literature (10,32).…”

Section: Casementioning

confidence: 69%

Section: Casementioning

confidence: 99%

Automobile Paint Reducer Induced Acute Kidney Injury

Latief¹,

Hassan²,

Wani³

et al. 2021

jrenhep

View full text Add to dashboard Cite

show abstract

“…For example, excess circulating haem caused by solvent-induced rhabdomyolysis or haemolysis of red blood cells has been posited to cause acute tubular necrosis and renal failure [56]. In agreement with this hypothesis, Ngajilo and Ehrlich [57], in a recent study reported a case of rhabdomyolysis with acute tubular necrosis and renal failure in a steel water tank cleaner exposed to a mixture of organic solvents containing toluene, xylene, acetone, hexane, benzene and methylisobutyl ketone.…”

Section: Gr Up Sm Copyright  Ekpenyong Cementioning

confidence: 90%

A Cross-Sectional Survey of Estimated Glomerular Filtration Rate, Acid-Base Balance and Electrolyte Status among Workers Exposed to Petroleum Products

Ekpenyong¹,

Inyang²

2017

J Nephrol Kidney Dis

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One study [13] showed that service station workers are exposed to gasoline inhalation many hours a week, approximately 8086 minutes per year. Besides gasoline station workers, many others are exposed to gasoline constituents during its procurement for domestic or commercial uses [14]. The frequency and amount of use of gasoline creates many potential exposures in a typical day. According to Wixton and Brown [15], about 110 million people are exposed to gasoline constituents within a few minutes per week and about 100 min/year during refueling at self-service gasoline station [9]. In terms of country ranking, United State of America tops the list of the first 10 countries regarded as the high-volume consumer of petroleum products [16]

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Where do you live and what do you do? Two questions that might impact your kidney health

Aoun¹,

Chelala²

2022

Front. Nephrol.

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In many cases the social determinants of health need to be assessed through their interaction with environmental factors. This review looks at the impact of physical location and occupation of individuals on their kidney health. It examines the effect of living at high altitude on kidney function and the relationship between extreme cold or hot temperatures and the incidence of kidney injury. It reviews as well the many occupations that have been linked to kidney disease in high-income and low-and-middle-income countries. As a conclusion, this overview proposes preventive recommendations that could be individualized based on weather, altitude, socio-economic level of the country and occupation of the individual.

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Rhabdomyolysis with acute tubular necrosis following occupational inhalation of thinners

Cited by 4 publications

References 6 publications

Automobile Paint Reducer Induced Acute Kidney Injury

Automobile Paint Reducer Induced Acute Kidney Injury

A Cross-Sectional Survey of Estimated Glomerular Filtration Rate, Acid-Base Balance and Electrolyte Status among Workers Exposed to Petroleum Products

Where do you live and what do you do? Two questions that might impact your kidney health

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