Rhabdomyolysis Associated with Acute Q Fever

Carrascosa, Miguel F; Pascual, Francisco; Borobio, M V; González, Zoilo Madrazo; Napal, J.

doi:10.1086/516064

Cited by 11 publications

(6 citation statements)

References 8 publications

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“…The highest CK level described during Q fever actually was 47659 IU/L. [6] Unusually high levels of CK might explain the development of ARF in the patient reported here, as CK levels are known to correlate with the development of ARF. [13] The pathogenesis of rhabdomyolysis in patient with acute C. burnetii infection is unclear.…”

Section: Discussionmentioning

confidence: 51%

“…Acute Q fever most commonly manifests as a self-limited febrile illness, atypical pneumonia, and hepatitis [2] ; a rare complication can be glomerulonephritis [3][4][5] and in some cases rhabdomyolysis. [6][7][8] The clinical manifestations of Q fever may be so variable that disease is often diagnosed only if it has been systematically considered. However, when evoked, a definite diagnosis of the disease is easy and remains based upon serology.…”

Section: Introductionmentioning

confidence: 99%

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Acute Renal Failure Associated with Rhabdomyolysis in Acute Q Fever

Ljutić

Radovnikovic

Kurir³

2007

Renal Failure

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The clinical presentation of Q fever is polymorphic and non-specific, and it may be presented as an acute or chronic disease. Renal complications of acute Q fever such as acute glomerulonephritis are not uncommon. Acute renal failure induced by rhabdomyolysis in acute Q fever has until now never been reported in the literature. We presented a case of acute Q fever associated by extreme rhabdomyolysis and consecutive acute renal failure. A male patient was treated with doxycycline and continuous venovenous hemodiafiltration. After two weeks of treatment, the patient completely recovered kidney function, and there were no clinical abnormalities. Acute Q fever must be considered as a possible cause of rhabdomyolysis and acute renal failure. The continuous venovenous hemodiafiltration may be effective, and it seems to be the treatment of choice in severe rhabdomyolysis and consecutive acute renal failure.

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Section: Discussionmentioning

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Acute Renal Failure Associated with Rhabdomyolysis in Acute Q Fever

Ljutić

Radovnikovic

Kurir³

2007

Renal Failure

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“…7 Furthermore, Q fever in children may present with skin rash, 8 gastrointestinal symptoms, 9 or more sever manifestations such as hemolytic uremic syndrome, 10 acute cholecystitis, 11 or rhabdomyolysis. 12 Similarly, Q fever infection shortly before conception or during pregnancy has been implicated in miscarriage, premature birth, intrauterine growth retardation, and stillbirths. 13 Collectively, these observations highlight the importance of screening for C burnetii infection, particularly, in clinical situations posing a diagnostic challenge.…”

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confidence: 99%

Q fever: a neglected zoonosis in Saudi Arabia

Almogren

Shakoor

Hasanato

et al. 2013

Annals of Saudi Medicine

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BACKGROUND AND OBJECTIVESInfection due to Coxiella burnetii (C burnetii), the causative agent of Q fever is rarely sought for in clinical practice. This study was performed to detect C burnetii infection in patients with pyrexia of undetermined cause (PUC).DESIGN AND SETTINGSThis is a prospective study conducted at King Khalid University Hospital, Riyadh between March 2011 and January 2013.PATIENTS AND METHODSA total of 3 mL venous blood was collected from 51 patients with PUC at King Khalid University Hospital, Riyadh. This group of patients included 30 males and 21 females (mean age 33.9 [21.3] years) with the history of febrile illness ranging between 4 and 8 weeks. A control group of 50 healthy individuals comprising 39 males and 11 females (mean age 27 [9] years) was also included in the study. Detection of phase II C burnetii–specific IgG antibodies was performed by immunofluorescence assay, and a titer of >1:64 was considered positive.RESULTSPhase II C burnetii–specific IgG antibodies were detected in 18 (35.2%) patients out of the total 51 tested. Two (4%) individuals out of 50 in the control group tested positive for anti–C burnetii IgG antibodies. The proportion of positive results among the patients was significantly higher than the controls (P<.0002, 95% CI, 15.09–46.25). The antibody titer range was between 1:128 and 1:1024 where 6 patients had titers of 1:256, 5 had 1:512, 4 had 1024, and 3 had 1:128.CONCLUSIONThe evidence of C burnetii infection in a sizable number of patients emphasizes the need for inclusion of serologic investigations for Q fever in patients with PUC.

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“…Other complications of acute Q fever include hemolytic anemia, myocarditis, pericarditis, pancreatitis, thyroiditis, mesenteric panniculitis, mediastinal lymphadenopathy, orchitis, erythema nodosum and optic neuritis [2]. However, rhabdomyolysis is an apparently uncommon complication of C. burnetii infection, and this association has rarely been reported [3–8]. Here we report another case of severe rhabdomyolysis secondary to acute Q fever.…”

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confidence: 99%

“…However, pathogenetic mechanisms of rhabdomyolysis in acute Q fever are unclear. Nevertheless, some authors have suggested that rhabdomyolysis in these patients might be a consequence of release of an endotoxin or exotoxin [3].…”

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confidence: 99%

Rhabdomyolysis in acute Q fever

Díaz¹,

Collazos

1999

Clinical Microbiology and Infection

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Tel: +31 43 3876643 Fax: +31 43 3876644 References 1. Aronson MD, Bor DH. Blood cultures. AM Intern Med 1987; 106: 246-53. 2. Ryan MR, Murray PR. Historical evolution of automated blood culture systems. Clin Mimbiol N e d e t t 1993; 1 5 105-8. 3. W b t e i n W. Current blood culture methods and systems: clinical concepts, technology, and interpretation of mule. Clin Infect Dis 1996; 23: 40-6. 4. Ziegler R, Johnsher I, Marms P, Lcnhardt D, Just H-M. Controlled clinical laboratory comparison of two supplemented aerobic and anaerobic media used in automated blood culture systems M detect bloodstream infections. J Clin Microbioll998; 3 6 65761. 5. Jorgcascn JH, Mirrct S, McDonald LC, et 11. Controlled clinical laboratory comparison of BACTEC plus aerobic/& medium with Bact/Alert aerobic F A N medium €or detection of bacteremia and f..9Mli.. J Clin Microbioll997; 35: 53-8. McRsen NEL, Jacobs JA. Blood volume in BACTEC plus/F culture bodes sampled using the direct-draw technique. Clin Microbiol Infect 1998 4 471-2. Alfa M, Sanche S, Roman S, Fiola Y, Lenton P, Harding G. Continuous quality improvements for introduction of automated blood cultun instrument. J Clin Microbiol 1995; 33: 1185-91. Martinez RM, Martinez R, P d Y, C w s J, Llosa J. A l m a g~~ M. An in&quent cause of false-positive blood cultures. Clin Microbiol Newslett 1993; 15: 7-8.

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Rhabdomyolysis Associated with Acute Q Fever

Cited by 11 publications

References 8 publications

Acute Renal Failure Associated with Rhabdomyolysis in Acute Q Fever

Acute Renal Failure Associated with Rhabdomyolysis in Acute Q Fever

Q fever: a neglected zoonosis in Saudi Arabia

Rhabdomyolysis in acute Q fever

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