Rhabdomyolysis-Associated Acute Kidney Injury

Esposito, Pasquale; Estienne, Luca; Serpieri, Nicoletta; Ronchi, Dario; Comi, Giacomo Pietro; Moggio, Maurizio; Peverelli, Lorenzo; Bianzina, Stefania; Rampino, Teresa

doi:10.1053/j.ajkd.2018.03.009

Cited by 31 publications

(34 citation statements)

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“…5,27,28 Acute kidney injury is one of the most serious complications of rhabdomyolysis. Almost 10 to 50% of patients with severe rhabdomyolysis develop AKI 3, 29,30 with reported mortality rates ranging between 13-59%. 29,31 The main mechanism of kidney damage in patients with rhabdomyolysis is the massive release of myoglobin into the circulation, with myoglobinuria.…”

Section: Discussionmentioning

confidence: 99%

“…Almost 10 to 50% of patients with severe rhabdomyolysis develop AKI 3, 29,30 with reported mortality rates ranging between 13-59%. 29,31 The main mechanism of kidney damage in patients with rhabdomyolysis is the massive release of myoglobin into the circulation, with myoglobinuria. 32 A number of etiologies have been attributed as the causes of rhabdomyolysis such as trauma, extreme physical exercise, hypophosphatemia, drugs, infections, hypokalemia, and others.…”

Section: Discussionmentioning

confidence: 99%

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Comparison between Rhabdomyolysis Induced and Septic Acute Kidney Injury in Central Nepal

et al. 2019

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Background: Acute kidney injury (AKI) is one of the most serious complications of rhabdomyolysis (RM). We studied the clinical manifestations and prognosis of rhabdomyolysis induced AKI and compared it with septic AKI among hospitalized patients. Methods: A prospective study was conducted at Chitwan Medical College between January 2017 to June 2018 to compare AKI secondary to rhabdomyolysis (RM-AKI) and sepsis (SA-AKI). AKI was diagnosed as per Kidney Disease Improving Global Outcomes (KDIGO) 2012 guidelines. Rhabdomyolysis was diagnosed if serum creatinine phosphokinase raised >5 times the upper limit of normal level and sepsis as an increase of two or more points in the Sequential Organ failure Assessment (SOFA) score with the evidence of infection. Results: A total of 145 patients with AKI (21 with RM and 124 with sepsis) were included in the study. Mean age of the patients was 43.7 years with majority (54%) being males. Wasp bite and bee sting combined together (47.6%) were the most common causes for RM-AKI whereas pneumonia accounted for 46.6% of the septic AKI. Serum creatinine (SCr) at admission and at discharge were 3.8 and 1.4 mg/dL respectively in RM-AKI group; and 2.4 and 1.6 mg/dL in septic AKI group. Duration of stays in the hospital (9.2 versus 6.4 days) and ICU (4.2 versus 3.7 days) were longer in RM than in septic AKI. In hospital mortality was 4.8% in RM and 8.9% in septic AKI. Conclusions: This study has found that, despite a longer duration of hospital stay, RM-AKI had a lower in-hospital mortality than septic AKI.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparison between Rhabdomyolysis Induced and Septic Acute Kidney Injury in Central Nepal

et al. 2019

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“…So, What is the best optimal management of RM-induced AKI ? The mainstays of efforts to prevent AKI in patients with rhabdomyolysis are saline solutions to expand intravascular volume and treatment of the underlying cause of rhabdomyolysis, [17] Renal replacement therapy should not be initiated on the basis of the myoglobin or CK serum concentration, but on the basis of the status of renal impairment. Continuous renal replacement therapy should only be considered when life-threatening electrolyte abnormalities emerge as complications of AKI, and they are not responsive to the initial therapy.…”

Section: Discussionmentioning

confidence: 99%

Causes, Clinical Features and Treatment of Rhabdomyolysis: A Retrospective Analysis

Yu¹

2018

AJIM

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Background: RM is a condition of skeletal muscle breakdown which ranges from an asymptomatic illness with elevation in CK level to a life-threatening condition associated with extreme elevation in CK, electrolyte imbalance, AKI, and disseminated intravascular coagulation. In this study, the author analyzed the causes, clinical features, and treatments of RM. Methods: The study collected the records of 48 patients in the First Affiliated Hospital of Jinan University who were diagnosed RM from June 2012 to August 2016. By using SPSS to analyse the data, the study draw a clear chart about the distribution of patients' age, etiologies and clinical symptoms respectively. The statistic analysis also reveals dramatically change on CK and other indicators after treatment. Results: A total of 48 patients were eligible for the study (mean age = 29.7 ± 12.3 years; 36 males and 12 females). Strenuous exercises and infections took the greatest percent amount the causes of RM. Muscular weakness and muscle aches were the two most common symptoms. Among the patients, 42 received intravenous (IV) fluid therapy, and none developed acute kidney injury (AKI). The other six patients accepted CRRT, five of whom had an alleviation of their symptoms. One patient was transferred to another hospital for further treatment since the primary disease was dermatomyositis and it was non-responsive to immunotherapy. Discussion and conclusions: RM is treatable if early diagnosis, comprehensive therapy, active prevention, and the timely elimination of complications are put into effect. Its main symptoms such as muscle aches, muscular weakness, and dark urine may not presented at the same time. In this study, Strenuous exercise is the most common cause of RM and IV fluid therapy is the cornerstone of RM treatment. CRRT should also be considered when life-threatening electrolyte abnormalities emerge as complications of AKI, or when the RM is non-responsive to initial therapy.

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“…Other components include varying types of proteoglycans and glycoproteins, which include elastin (Hynes and Naba, 2012). Additional noteworthy components of the ECM are lysyl oxidase and hydroxylase (LOX and LOXL) (Kirschmann et al, 2002; Payne et al, 2007; Nilsson et al, 2016; Esposito et al, 2018). These secreted copper-dependent amine oxidases function to cross-link collagen and elastin, enabling them to play key roles in tumor progression and metastasis (Nilsson et al, 2016; Esposito et al, 2018).…”

Section: Extracellular Matrix Composition and Cancer Progressionmentioning

confidence: 99%

“…Additional noteworthy components of the ECM are lysyl oxidase and hydroxylase (LOX and LOXL) (Kirschmann et al, 2002; Payne et al, 2007; Nilsson et al, 2016; Esposito et al, 2018). These secreted copper-dependent amine oxidases function to cross-link collagen and elastin, enabling them to play key roles in tumor progression and metastasis (Nilsson et al, 2016; Esposito et al, 2018). Indeed, many studies have outlined the effects and mechanism of action of LOX/LOXL in a myriad of oncogenic settings (Palamakumbura et al, 2009; Barker et al, 2012; Cox et al, 2016).…”

Section: Extracellular Matrix Composition and Cancer Progressionmentioning

confidence: 99%

YAP/TAZ Related BioMechano Signal Transduction and Cancer Metastasis

Martinez

Yang

Harker

et al. 2019

Front. Cell Dev. Biol.

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Mechanoreciprocity refers to a cell’s ability to maintain tensional homeostasis in response to various types of forces. Physical forces are continually being exerted upon cells of various tissue types, even those considered static, such as the brain. Through mechanoreceptors, cells sense and subsequently respond to these stimuli. These forces and their respective cellular responses are prevalent in regulating everything from embryogenic tissue-specific differentiation, programmed cell death, and disease progression, the last of which being the subject of extensive attention. Abnormal mechanical remodeling of cells can provide clues as to the pathological status of tissues. This becomes particularly important in cancer cells, where cellular stiffness has been recently accepted as a novel biomarker for cancer metastasis. Several studies have also elucidated the importance of cell stiffness in cancer metastasis, with data highlighting that a reversal of tumor stiffness has the capacity to revert the metastatic properties of cancer. In this review, we summarize our current understanding of extracellular matrix (ECM) homeostasis, which plays a prominent role in tissue mechanics. We also describe pathological disruption of the ECM, and the subsequent implications toward cancer and cancer metastasis. In addition, we highlight the most novel approaches toward understanding the mechanisms which generate pathogenic cell stiffness and provide potential new strategies which have the capacity to advance our understanding of one of human-kinds’ most clinically significant medical pathologies. These new strategies include video-based techniques for structural dynamics, which have shown great potential for identifying full-field, high-resolution modal properties, in this case, as a novel application.

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Rhabdomyolysis-Associated Acute Kidney Injury

Cited by 31 publications

References 4 publications

Comparison between Rhabdomyolysis Induced and Septic Acute Kidney Injury in Central Nepal

Comparison between Rhabdomyolysis Induced and Septic Acute Kidney Injury in Central Nepal

Causes, Clinical Features and Treatment of Rhabdomyolysis: A Retrospective Analysis

YAP/TAZ Related BioMechano Signal Transduction and Cancer Metastasis

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