Rhabdomyolyse sévère révélant une myopathie hypothyroïdienne d’origine auto-immune

Mouzouri, H.; Omri, N.; Sekkach, Y.; Frikh, Rachid; Nzambe, C.; Qacif, H.; Balkhi, H.; Makouar, F.; Qatni, M. El; Belmejdoub, G.; Rkiouak, F.; Ghafir, D.; Ohayon, V.; Archane, M. I.

doi:10.1016/j.ando.2008.05.001

Cited by 6 publications

(1 citation statement)

References 9 publications

(15 reference statements)

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“…Various hypotheses have been postulated, such as mitochondrial oxidative metabolism, induction of insulin-resistant state, and decreased muscle carnitine levels, including autoimmune mechanism. 11,13 Also, deficiency in thyroxine leads to abnormal glycogenolysis and increased triglyceride turnover, thus leading to the impairment of muscle function by causing a transition from fast-twitching type 2 muscle fibers to slow-twitching type 1 fibers, low myosin ATPase activity, and low ATP turnover in the skeletal muscles. 14…”

Section: Discussionmentioning

confidence: 99%

Severe hypothyroidism‐induced rhabdomyolysis: A case report

Baghi

Sirajudeen

Naushad

et al. 2021

Clinical Case Reports

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Section: Discussionmentioning

confidence: 99%

Severe hypothyroidism‐induced rhabdomyolysis: A case report

Baghi

Sirajudeen

Naushad

et al. 2021

Clinical Case Reports

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Hypothyroid myopathy: A peculiar clinical presentation of thyroid failure. Review of the literature

Sindoni

Rodolico

Pappalardo

et al. 2016

Rev Endocr Metab Disord

100

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Abnormalities in thyroid function are common endocrine disorders that affect 5-10 % of the general population, with hypothyroidism occurring more frequently than hyperthyroidism. Clinical symptoms and signs are often nonspecific, particularly in hypothyroidism. Muscular symptoms (stiffness, myalgias, cramps, easy fatigability) are mentioned by the majority of patients with frank hypothyroidism. Often underestimated is the fact that muscle symptoms may represent the predominant or the only clinical manifestation of hypothyroidism, raising the issue of a differential diagnosis with other causes of myopathy, which sometimes can be difficult. Elevated serum creatine kinase, which not necessarily correlates with the severity of the myopathic symptoms, is certainly suggestive of muscle impairment, though it does not explain the cause. Rare muscular manifestations, associated with hypothyroidism, are rhabdomyolysis, acute compartment syndrome, Hoffman's syndrome and Kocher-Debré-Sémélaigne syndrome. Though the pathogenesis of hypothyroid myopathy is not entirely known, proposed mechanisms include altered glycogenolytic and oxidative metabolism, altered expression of contractile proteins, and neuro-mediated damage. Correlation studies of haplotype, muscle gene expression and protein characterization, could help understanding the pathophysiological mechanisms of this myopathic presentation of hypothyroidism.

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Rhabdomyolysis: a rare complication of Hashimoto’s thyroiditis precipitated by statin therapy

Peringat

Manappallil²,

Karadan

2018

BMJ Case Reports

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Hashimoto's thyroiditis (HT) or chronic lymphocytic thyroiditis is the most common form of primary hypothyroidism. Muscular manifestations like weakness, pain, stiffness and elevated muscle enzymes have been noticed in hypothyroidism. Statins are also known to cause myositis and rhabdomyolysis. This is a case of a middle-aged man, on statin therapy, who presented with severe muscle aches and pain and was found to have rhabdomyolysis. Further evaluation revealed an underlying HT as the culprit for his condition. He was managed with intravenous fluids and levothyroxine along with cessation of statins, following which he improved.

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Rhabdomyolyse sévère révélant une myopathie hypothyroïdienne d’origine auto-immune

Cited by 6 publications

References 9 publications

Severe hypothyroidism‐induced rhabdomyolysis: A case report

Severe hypothyroidism‐induced rhabdomyolysis: A case report

Hypothyroid myopathy: A peculiar clinical presentation of thyroid failure. Review of the literature

Rhabdomyolysis: a rare complication of Hashimoto’s thyroiditis precipitated by statin therapy

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