Rhabdomyolyse induite par le fénofibrate en monothérapie

Archambeaud-Mouveroux, F.; Lopez, S.; Combes, Clémentine; Lassandre, S.; Amaniou, M.; Teissier, M.P.; Galinat, S.

doi:10.1016/j.revmed.2006.02.013

Cited by 4 publications

(3 citation statements)

References 8 publications

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“…One of the side effects of the use of fenofibrate in adults is rhabdomyolosis, which is characterized by myalgia, weakness, dark urine and is a cause for acute renal failure [30], [31], [32], [33], [34]. However, while the use of fenofibrate in children has been described, there is no report of the occurrence of rhabdomyolosis [35].…”

Section: Discussionmentioning

confidence: 99%

Fenofibrate Reduces Mortality and Precludes Neurological Deficits in Survivors in Murine Model of Japanese Encephalitis Viral Infection

Sehgal¹,

Kumawat²,

Basu³

et al. 2012

PLoS ONE

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BackgroundJapanese encephalitis (JE), the most common form of viral encephalitis occurs periodically in endemic areas leading to high mortality and neurological deficits in survivors. It is caused by a flavivirus, Japanese encephalitis virus (JEV), which is transmitted to humans through mosquitoes. No effective cure exists for reducing mortality and morbidity caused by JEV infection, which is primarily due to excessive inflammatory response. Fenofibrate, a peroxisome proliferator-activated receptor-α (PPARα) agonist is known to resolve inflammation by repressing nuclear factor-κB (NF-κB) and enhancing transcription of anti-oxidant and anti-inflammatory genes. In addition, fenofibrate also up-regulates a class of proteins, cytochrome P4504Fs (Cyp4fs), which are involved in detoxification of the potent pro-inflammatory eicosanoid, leukotriene B4 (LTB4) to 20-hydroxy LTB4.Methodology/Principal FindingsThe neuroprotective effect of fenofibrate was examined using in vitro (BV-2 microglial cell line) and in vivo (BALB/c mice) models of JEV infection. Mice were treated with fenofibrate for 2 or 4 days prior to JEV exposure. Pretreatment with fenofibrate for 4 but not 2 days reduced mortality by 80% and brain LTB4 levels decreased concomitantly with the induction of Cyp4f15 and 4f18, which catalyze detoxification of LTB4 through hydroxylation. Expression of cytokines and chemokine decreased significantly as did microglial activation and replication of the JEV virus.Conclusions/SignificanceFenofibrate confers neuroprotection against Japanese encephalitis, in vivo, in mouse model of JEV infection. Thus, fenofibrate, a PPARα agonist that is commonly used as a hypolipidemic drug could potentially be used for prophylaxis during JE epidemics to reduce mortality and morbidity.

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Section: Discussionmentioning

confidence: 99%

Fenofibrate Reduces Mortality and Precludes Neurological Deficits in Survivors in Murine Model of Japanese Encephalitis Viral Infection

Sehgal¹,

Kumawat²,

Basu³

et al. 2012

PLoS ONE

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“…Rhabdomyolysis results from inherited muscle enzyme deficiencies, toxins such as alcohol and opiates, trauma, medication such as fibrates and statins, muscle overexertion, infections, hypothyroidism and other disorders (3)(4)(5). Alcohol abuse, trauma, the use of fibrates, statins, antipsychotics, selective serotonin reuptake inhibitors, or lithium, infection and hypothyroidism were excluded in our patient.…”

Section: Discussionmentioning

confidence: 99%

“…Myoglobinuria is the most significant consequence, leading to acute renal failure (ARF) in 15%-33% of patients with rhabdomyolysis. Rhabdomyolysis results from inherited muscle enzyme deficiencies, toxins such as alcohol, opiates and cocaine, trauma, medications such as fibrates and statins, muscle overexertion, infections, hypothyroidism and other disorders (3)(4)(5). Rhabdomyolysis has been reported in 22 of 188 consecutive patients with acute opiate intoxication (6).…”

Section: Introductionmentioning

confidence: 99%

Opium-Induced Rhabdomyolysis and Acute Renal Failure in a Patient Taking Opium Habitually: a Case Report

Sarı¹,

Sarıkaya²,

Çetinkaya³

et al. 2012

Erciyes Med J

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ÖZETSon 6 aydır sürekli afyon kullanan ve kas güçsüzlüğü şikâyeti olan 60 yaşındaki hipertansif ve diyabetik erkek hasta, rabdomiyoliz ve akut böbrek yetmezliği nedeniyle hastanemize gönderildi. Laboratuvar incelemesinde serum kreatinin kinaz, kreatinin ve laktat dehidrogenaz enzim yüksekliği saptandı. İntravenöz hidrasyon, bikarbonat ve mannitol tedavisi uygulandı. Takipler esnasında serum kreatin kinaz düzeyleri ve böbrek fonksiyon testlerinde gerileme oldu. Opiyat içeren ilaçların akut zehirlenmeleri rabdomiyolize neden olabilirken; sürekli afyon kullanımı da rabdomiyoliz nedenlerinden biridir. Bu yazıda afyon kullanımı sırasında rabdomiyoliz ve akut böbrek yetmezliği gelişen bir olgu sunuluyor ve sürekli afyon kullanımının rabdomiyoliz ve onunla ilişkili akut böbrek yetmezliğine neden olabileceği vurgulanıyor.Anah tar kelimeler: Akut böbrek hasarı, opiyum, rabdomiyoliz

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