Rhabdoid Tumor of the Kidney: A New Case of Prenatal Diagnosis with Metastases Immediately

Abstract

Rhabdoid tumor of the kidney is a rare pediatric malignancy arising most of the time before the age of two years. The diagnosis is generally difficult. The treatment is not well codified and the forecast remains very dark in spite of the progress of the pediatric oncology. We report a new case of rhabdoid renal tumor diagnosed prenatally and we specify our diagnostic and therapeutic approach.

Prenatal Diagnosis of Renal Rhabdoid Tumor: A Rare Malignant Neoplasm

“…Nevertheless, Trabelsi et al have reported a case of malignant renal rhabdoid tumor with hepatic and skin metastasis in a neonate. 24 The majority of malignant renal rhabdoid tumors were reported to involve single-gene mutations involving SMARCB1 and rarely SMARCA4 gene, 25 both of which were identified in the stored DNA sample of the neonate in our case. There are no reports of fetomaternal transmission of the malignancy so far; the mother is under follow-up for the same.…”

Aggressive uncommon pediatric renal tumor: Rhabdoid tumor of kidney

“…Mortality is 80-90% despite intensive multimodal chemotherapy, radiotherapy and/or surgical treatment. 10…”

Rhabdoid Tumor of the Kidney in Children: A Case Report

“…The International Incidence of pediatric Cancer study's database shows that it accounts for 2% of all pediatric kidney malignancies [4,6].…”

“…The tumor arises during the perinatal period, the first year of life, and in certain older individuals. It affects males more than females (1.5:1), with the average age at diagnosis being around 18 months [4,6].…”

“…Common symptoms at presentation include gross hematuria and abdominal masses as well as metastases to the lymph nodes, lungs, peritoneum, liver, and central nervous system. Also, can present with hypercalcemia from elevated serum parathormone levels, abdominal distension or pain, fussiness, and fever [4,6,7].…”