Rhabdoid Meningioma: Report of Two Cases

Reddy, Ch. Karunakar; Rao, Anand; Ballal, Chandra Kumar; Chakraborti, Shrijeet

doi:10.7860/jcdr/2015/11163.5571

Cited by 4 publications

(3 citation statements)

References 9 publications

(13 reference statements)

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“…Together, with 3 more cases published in non-PubMed journals, we were able to retrieve a total of 17 pediatric cases (Table 2). [4][5][6]10,13,[15][16][17][18]32,35,37,38,40,41,49,51 The duration of symptoms before the diagnosis of RM was reported to be less than half a year. 23 Intracranial RMs are usually isointense to gray matter on T1-weighted images and hyperintense on T2-weighted images.…”

Section: Discussionmentioning

confidence: 99%

Ectopic rhabdoid meningioma of the orbit in a child: case report and review of the literature

Yeşiltaş¹,

Günduz²,

Heper

et al. 2018

Journal of Neurosurgery: Pediatrics

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In August 2016, an 11-year-old boy presented to the authors’ institution with a right orbital tumor that was located superotemporally (superolaterally) and adherent to the sclera. The patient’s past medical history revealed that he had undergone 2 previous craniotomies elsewhere in June 2008 and July 2010 for a superomedially located orbital lesion that had been histopathologically diagnosed as a neurothekeoma. After the second craniotomy, the patient underwent adjuvant intensity modulated radiotherapy (IMRT) to the right medial orbit. At the authors’ institution, total excision of the orbital tumor was performed via an anterior conjunctival orbitotomy. Histopathological examination revealed a rhabdoid meningioma. Review of the histopathology obtained at the time of previous tumor excisions showed that the lesion was misdiagnosed as neurothekeoma and instead represented a meningioma from the beginning. The patient was started on a regimen of oral sunitinib and remained free of recurrence at 1.5 years of follow-up. Ectopic meningioma of the orbit is a rare entity. Rhabdoid meningioma is a rarely seen subtype of meningioma, accounting for 1%–3% of all intracranial meningiomas. To the best of the authors’ knowledge, this is the first case of an ectopic orbital rhabdoid meningioma reported in the literature. They suspect that tumor seeding during the previous surgeries might have played a role in the occurrence of the tumor in an orbital location not targeted by IMRT.

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Section: Discussionmentioning

confidence: 99%

Ectopic rhabdoid meningioma of the orbit in a child: case report and review of the literature

Yeşiltaş¹,

Günduz²,

Heper

et al. 2018

Journal of Neurosurgery: Pediatrics

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“…First, we performed a deep review of RM cases previously reported in the literature between 1998 and 2021 [ 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 ]. A total of 305 RM cases were identified, including adults and children or adolescents under the age of 18 years.…”

Section: Methodsmentioning

confidence: 99%

Clinical, Histopathologic and Genetic Features of Rhabdoid Meningiomas

Ruiz

González-Tablas

Peña

et al. 2023

IJMS

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Rhabdoid meningiomas (RM) shows heterogeneous histological findings, and a wide variety of chromosomal copy number alterations (CNA) are associated with an unpredictable course of the disease. In this study, we analyzed a series of 305 RM samples from patients previously reported in the literature and 33 samples from 23 patients studied in our laboratory. Monosomy 22-involving the minimal but most common recurrent region loss of the 22q11.23 chromosomal region was the most observed chromosomal alteration, followed by losses of chromosomes 14, 1, 6, and 19, polysomies of chromosomes 17, 1q, and 20, and gains of 13q14.2, 10p13, and 21q21.2 chromosomal regions. Based on their CNA profile, RM could be classified into two genetic subgroups with distinct clinicopathologic features characterized by the presence of (1) chromosomal losses only and (2) combined losses and gains of several chromosomes. The latter displays a higher frequency of WHO grade 3 tumors and poorer clinical outcomes.

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“…These anaplastic meningiomas represent 1–2% of all meningiomas. They are associated with rapid growth, brain invasion and frequent recurrences [3], [4]. …”

Section: Introductionmentioning

confidence: 99%