Rh single-atom nanozymes for efficient ascorbic acid oxidation and detection

Shi, Xiaoyue; Li, Juan; Xiong, Yu; Liu, Ziyu; Zhan, Jinhua; Cai, Bin

doi:10.1039/d3nr00488k

Cited by 15 publications

(7 citation statements)

References 56 publications

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“…Xu et al 109 160 and therapeutic treatments. 161 The catalytic attributes of rhodium nanozymes make them valuable in processes involving the breakdown of ROS and other biochemical reactions.…”

Section: Sepsismentioning

confidence: 99%

“…PMCS SAzyme exhibited good biocompatibility with minimal Zn 2+ leakage, demonstrating its potential in vivo applicability. In vitro antibacterial tests using 160 and therapeutic treatments. 161 The catalytic attributes of rhodium nanozymes make them valuable in processes involving the breakdown of ROS and other biochemical reactions.…”

Section: Sepsismentioning

confidence: 99%

“…Rhodium-based nanozymes can imitate the functions of natural enzymes like peroxidase, catalase, and superoxide dismutase. Notably, their peroxidase-like activity allows them to catalyze reactions involving H 2 O 2 , holding significance in applications related to sensing and therapeutic treatments . The catalytic attributes of rhodium nanozymes make them valuable in processes involving the breakdown of ROS and other biochemical reactions.…”

Section: Metal Atom-based Nanozymes For Treatmentsmentioning

confidence: 99%

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Single-Atom-Based Nanoenzyme in Tissue Repair

Fu,

Fan,

et al. 2024

ACS Nano

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Since the discovery of ferromagnetic nanoparticles Fe 3 O 4 that exhibit enzyme-like activity in 2007, the research on nanoenzymes has made significant progress. With the in-depth study of various nanoenzymes and the rapid development of related nanotechnology, nanoenzymes have emerged as a promising alternative to natural enzymes. Within nanozymes, there is a category of metal-based single-atom nanozymes that has been rapidly developed due to low cast, convenient preparation, long storage, less immunogenicity, and especially higher efficiency. More importantly, single-atom nanozymes possess the capacity to scavenge reactive oxygen species through various mechanisms, which is beneficial in the tissue repair process. Herein, this paper systemically highlights the types of metal single-atom nanozymes, their catalytic mechanisms, and their recent applications in tissue repair. The existing challenges are identified and the prospects of future research on nanozymes composed of metallic nanomaterials are proposed. We hope this review will illuminate the potential of singleatom nanozymes in tissue repair, encouraging their sequential clinical translation.

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Section: Sepsismentioning

confidence: 99%

Section: Sepsismentioning

confidence: 99%

Section: Metal Atom-based Nanozymes For Treatmentsmentioning

confidence: 99%

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Single-Atom-Based Nanoenzyme in Tissue Repair

Fu,

Fan,

et al. 2024

ACS Nano

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“…7 Therefore, it is important to accurately assess the AA levels in various foods and tablets. Although many methods, including colorimetry, 8 chromatography, 9 electrochemical method, 10 and fluorescence methods 11 have been developed for AA detection. There is scarcely any report in which the AA level and total antioxidant capacity can be simultaneously distinguished.…”

Section: ■ Introductionmentioning

confidence: 99%

Natural Enzyme-Inspired Design of the Single-Atom Cu Nanozyme as Dual-Enzyme Mimics for Distinguishing Total Antioxidant Capacity and the Ascorbic Acid Level

Tao,

Jiang,

Chu

et al. 2024

Anal. Chem.

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Although various oxidase mimetic or peroxidase (POD) mimetic nanozymes have been extensively studied, their poor substrate selectivity significantly inhibits their practical applications. Nanozymes with specific biomolecules as substrates, especially ascorbic acid oxidase (AAO) mimetic nanozymes with ascorbic acid (AA) as a substrate, have scarcely been studied. Herein, inspired by the multi-Cu atom sites and the redox electron transfer pathway of Cu 2+ /Cu + in the natural AAO, atomically dispersed Cu sites immobilized on N-doped porous carbon (Cu-N/C) are artificially designed to simulate the function of natural AAO. Compared with their natural counterparts, the Cu-N/C catalysts exhibited higher catalytic efficiency and superior stability. Combined theoretical calculation and experimental characterizations reveal that the Cu-N/C nanozymes could catalyze the AA oxidation through a 2e − oxygen reduction pathway with H 2 O 2 as the product. Moreover, the Cu-N/C nanozymes also possess high POD activity. As a proof-of-concept application, Cu-N/C can simultaneously realize AA detection in fluorescent mode based on its AAO activity and total antioxidant capacity detection in colorimetric mode utilizing its POD activity.

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“…[9,10] For example, nanozymes, which mimic the enzymes' natural active site environment have been designed and tested. [11,12] Recently, Ding et al developed a 1D nanowire with Fe-N 4 sites doped with phosphorous to enhance its peroxidase-like activity for biosensing assays. [13] Deng et al developed an artificial metalloenzyme by substituting myoglobin hemin with cobalt porphyrin for photocatalytic CO 2 reduction.…”

Section: Introductionmentioning

confidence: 99%

A Bioengineered Stable Protein 1‐Hemin Complex with Enhanced Peroxidase‐Like Catalytic Properties

Zeibaq,

Bachar,

Sklyar

et al. 2024

Small Science

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Enzymes have gained their unique efficiency and catalytic activity through billions of years of evolution, perfecting their active site to a desired reaction. Inspired by nature, a novel enzyme‐mimicking platform is designed based on stable protein 1 (SP1) to create a nano‐compartment that mimics peroxidase activity. The biohybrid reveals enhanced activity over the hemin cofactor alone and improved stability in organic solvents in comparison to native peroxidase. Furthermore, the utilization of the obtained biohybrid in an optical glucose biosensing platform is shown. The biohybrid crystallographic structure is solved, indicating that the SP1 structure is not affected by the hemin coordination. This work opens the path for developing new cofactor binding centers in engineered protein scaffolds for various artificial catalytic processes.

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Rh single-atom nanozymes for efficient ascorbic acid oxidation and detection

Abstract: The management of ascorbic acid (AA) in biological fluids is of significant importance for body functions and human health yet challenging due to the lack of high-performance sensing catalysts. Herein,...

Cited by 15 publications

References 56 publications

Single-Atom-Based Nanoenzyme in Tissue Repair

Single-Atom-Based Nanoenzyme in Tissue Repair

Natural Enzyme-Inspired Design of the Single-Atom Cu Nanozyme as Dual-Enzyme Mimics for Distinguishing Total Antioxidant Capacity and the Ascorbic Acid Level

A Bioengineered Stable Protein 1‐Hemin Complex with Enhanced Peroxidase‐Like Catalytic Properties

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