Rh factor is associated with individual radiosensitivity: A cytogenetic study

Khosravifarsani, Meysam; Monfared, Ali Shabestani; Borzoueisileh, Sajad

doi:10.19082/2828

Cited by 3 publications

(8 citation statements)

References 17 publications

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“…HB as a factor which plays a role in oxygen delivery to the tissues and could be important in clinical outcomes of radiotherapy because the oxygen is one of the most important modulating factors which improves the radiation damages and could sensitize the tissue. Furthermore, our data showed that the platelet counts were decreased at weeks 2, 3 and four compared to the time before starting the treatment process which is pointing out to the fact that their lifespan is 9-10 days (23). The mean of PLT count in each blood group was not significantly different to other blood groups which implies that the effect of radiation on PLT might be independent of the effect of ABO blood group and the repeated PLT counts analysis showed that PLT counts and blood group are not signifi cantly associated with time.…”

Section: Discussionsupporting

confidence: 51%

“…Elahimaneshet alreported that A + and 0 + blood groups are more and less radiosensitive than other blood groups (15) that is in agreement with our results. Also, Khosravifarsani et al reported that there is an association between Rh factor and radiosensitivity (23) which suggests that genetic factors including ABO blood groups should be taken into account in individualization of radiotherapy. And could be a very simple and achievable factor predicting patient's response/adverse reaction induced by irradiation in radiotherapy for cancer treatment or also use radionuclide for diagnostic intends.…”

Section: Discussionmentioning

confidence: 99%

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ABO blood groups as a new potential predictive factor in radiotherapy hematological changes

Seyfizadeh¹,

Saboori²,

Borzoueisileh³

et al. 2020

BLL

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AIM: Cancer treatments specially with new high Tec radiotherapy equipment's calling daily progression in method and predictive factors affecting treatment goals. Due to important effect of oxygen on cells radio sensitivity, tumor blood circulation and it's antigens like ABO blood groups maybe an important predictive factor for radiotherapy response and it is adverse events. The aim of this study was the assessment of the hematological manifestations of local radiotherapy and association with ABO blood groups. METHODS: In this observational study, 2 ml of peripheral blood were taken from 152 patients with routine 3D conformal radiotherapy treatment course and the blood parameters achieve and documented at four stage during treatment courses. The data were analyzed by repeated measurement andone-way ANOVA. RESULTS: Statistically signifi cant reductions of the platelets, white blood cells (WBC), and lymphocytes counts were demonstrated. Also an increased percentage of polymorphonuclear cells during local radiotherapy exposure was found. The changes in WBC counts were observed to be in association with ABO blood groups. The other evaluated factors were not signifi cantly associated with ABO blood groups. CONCLUSIONS: Our results showed an association between radiotherapy patients ABO blood groups and some hematological changes in their blood circulation (Fig. 7, Ref. 23).

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Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

ABO blood groups as a new potential predictive factor in radiotherapy hematological changes

Seyfizadeh¹,

Saboori²,

Borzoueisileh³

et al. 2020

BLL

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“…They also stated that molecular investigation to evaluate candidate loci involved in the DNA repair systems on chromosome 9 near ABO locus at 9q34 should be performed in order to validate the association between blood groups and radiosensitivity [10]. Regarding the Rh system, the study by Khosravifarsani et al showed that Rh-was less sensitive to radiation compared to Rh+ [31]. Since in our study all samples have Rh+, we cannot evaluate the association between Rh and radiosensitivity.…”

Section: Association Between Blood Group and Radiosensitivitymentioning

confidence: 89%

Assessment of Individual Radiosensitivity in Inhabitants of Takandeang Village － A High Background Radiation Area in Indonesia

et al. 2019

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People living in high background radiation areas (HBRAs) possibly develop the radioadaptive response (RAR) phenomenon. The Mamuju area in West Sulawesi Indonesia is known as an HBRA in Indonesia due to its high natural uranium contents. It is possible that RAR has developed in Mamuju inhabitants. To prove this hypothesis, here in this study, evaluation of the individual radiosensitivity in the inhabitants of Takandeang Village, Mamuju, was conducted using G 2 micronucleus (MN) assay. Association between blood groups and TP53 Arg72Pro polymorphism with individual radiosensitivity was also evaluated in this study. Using G 2 MN assay, we assessed the individual radiosensitivity of Takandeang Village inhabitants and control samples. For each sample, three parameters were calculated. The spontaneous (baseline) MN number, MN number after 0.5 Gy in vitro irradiation, and radiation-induced MN were calculated to predict the individual radiosensitivity. The radiation-induced MN was defined by subtracting the spontaneous MN number from the MN number after irradiation. The mean and SD of the number of micronuclei induced by radiation found in control group (CG) was set as the cutoff value to determine the individual radiosensitivity in all samples. The occurrence of a radiation-induced MN value higher than the mean CG + 1SD CG was scored as 1, indicating a milder radiosensitive phenotype, whereas a result higher than the mean CG + 2SD CG was scored as 2, and indicated a more severe radiosensitive phenotype. When the individual value was lower than the mean CG + 1SD CG, a score of 0 was attributed to the tested subject. The results showed that four individuals in Takandeang Village inhabitants had a milder radiosensitive phenotype, while the others were categorized as normal radiosensitive. A similar finding was also found in control samples. Our study failed to find any correlation between radiosensitivity and either blood group or the TP53 Arg72Pro polymorphism. Overall, our study revealed the possibility of RAR phenomena in Takandeang Village inhabitants. Further investigation using a different point of radiation dose value and larger sample number should be performed to validate this study results.Journal homepage: http://aij.batan.go.id

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“…It has also been reported that the blood types and Rh factor is known to influence the radiosensitivity measured using MN assay; the blood types A and O were shown to be more sensitive than other blood types. 11,27 The differential response of lymphocyte proliferation measured by MI among the blood types indicates that blood type may be a prominent confounding factor for lymphocyte proliferation after radiation exposure. Future studies involving a large number of human samples of different blood types are required to verify whether or not the radio response of lymphocytes is modulated by blood types.…”

Section: Discussionmentioning

confidence: 99%

“…4 The mitotic index (MI) 5 and/or nuclear division index (NDI) 6 are the reliable measures of lymphocyte proliferation under stimulated in vitro. 11 Another study has shown that among the Rh + subjects, people with A + blood type exhibited highest radiosensitivity index and O + blood types with the lowest index among various blood types. 10 Recently it has been demonstrated that residual chromosome damage measured as MN formation, in 2 Gy irradiated PBL showed statistical differences between blood types differ in their Rh antigen.…”

mentioning

confidence: 97%

Does proliferation capacity of lymphocytes depend on human blood types?

Viswanathan

Kanagaraj

Raavi

et al. 2018

J of Cellular Biochemistry

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In vitro human lymphocyte culture methodology is well established yet certain confounding factors such as age, medical history as well as individual’s blood type may potentially modulate in vitro proliferation response. These factors have to be carefully evaluated to release reliable test report in routine cytogenetic evaluation for various genetic conditions, radiation biodosimetry, etc. With this objective, the current study was focused on analyzing the proliferation response of lymphocytes drawn from 90 individuals (21‐29 years) with different blood types. The proliferation response was assessed in the cultured lymphocytes by cell cycle, mitotic index (MI), and nuclear division index (NDI) after stimulation with phytohaemagglutinin (PHA). To investigate the toxic effect on proliferation, MI was calculated in representative samples of each blood type were X‐irradiated. The results showed that there was no significant difference among the cell cycle phases of lymphocytes in different blood types (P > 0.05). Similarly, both MI and NDI of lymphocytes derived from different blood types also did not show significant difference ( P > 0.05). The extensive interindividual variation within and among the blood types is likely responsible for the lack of significant difference in lymphocyte proliferation. Although spontaneous proliferation efficiency of lymphocytes of different blood types after PHA stimulation was grossly similar, the MI observed after radiation exposure showed a significant difference ( P < 0.05) indicating a differential proliferation response among the blood types. Our results suggest that the blood types did not have any impact on PHA‐induced proliferation; however, a specific differential lymphocyte proliferation observed after radiation exposure needs to be considered.

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Rh factor is associated with individual radiosensitivity: A cytogenetic study

Cited by 3 publications

References 17 publications

ABO blood groups as a new potential predictive factor in radiotherapy hematological changes

ABO blood groups as a new potential predictive factor in radiotherapy hematological changes

Assessment of Individual Radiosensitivity in Inhabitants of Takandeang Village － A High Background Radiation Area in Indonesia

Does proliferation capacity of lymphocytes depend on human blood types?

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