RGS6 drives cardiomyocyte death following nucleolar stress by suppressing Nucleolin/miRNA-21
Abhishek Singh Sengar,
Manish Kumar,
Chetna Rai
et al.
Abstract:Background
Prior evidence demonstrated that Regulator of G protein Signaling 6 (RGS6) translocates to the nucleolus in response to cytotoxic stress though the functional significance of this phenomenon remains unknown.
Methods
Utilizing in vivo gene manipulations in mice, primary murine cardiac cells, human cell lines and human patient samples we dissect the participation of a RGS6-nucleolin complex in chemotherapy-dependent cardiotoxicity.
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