RGD peptide-modified fluorescent gold nanoclusters as highly efficient tumor-targeted radiotherapy sensitizers

Liang, Guohai; Jin, Xudong; Zhang, Shuxu; Xing, Da

doi:10.1016/j.biomaterials.2017.08.017

Cited by 137 publications

(103 citation statements)

References 42 publications

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“…Due to the fast clearance of the NCs, the untargeted Au NCs have a low accumulation in PSMA‐lacking tumors with 2% of injected dose (ID/g) in contrast to the targeted Au 25 NCs that showed a high accumulation in PC3pip tumors with 8.9% ID/g at 4 h post injection. This is greater than that achieved for RGD‐targeted nanoclusters, which reached 6.4% ID/g in 4T1 tumors after 4 h . Moreover, the Au content in the liver is less than 3% ID/g, which is much lower (about 1/5) compared to a study by Tsvirkun et al using 10, 30, and 100 nm gold nanoparticles .…”

contrasting

confidence: 62%

Targeted Gold Nanocluster‐Enhanced Radiotherapy of Prostate Cancer

Luo

Wang

Zeng

et al. 2019

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For over a hundred years, X‐rays have been a main component of the radiotherapeutic approaches to treat cancer. Yet, to date, no radiosensitizer has been developed to selectively target prostate cancer. Gold has excellent X‐ray absorptivity and is used as a radiotherapy enhancing material. In this work, ultrasmall Au25 nanoclusters (NCs) are developed for selective prostate cancer targeting, radiotherapy enhancement, and rapid clearance from the body. Targeted‐Au25 NCs are rapidly and selectively taken up by prostate cancer in vitro and in vivo and also have fast renal clearance. When combined with X‐ray irradiation of the targeted cancer tissues, radiotherapy is significantly enhanced. The selective targeting and rapid clearance of the nanoclusters may allow reductions in radiation dose, decreasing exposure to healthy tissue and making them highly attractive for clinical translation.

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confidence: 62%

Targeted Gold Nanocluster‐Enhanced Radiotherapy of Prostate Cancer

Luo

Wang

Zeng

et al. 2019

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“…Other than size, different AuNMs shapes also play an influence on their efficiency in radiotherapy, with spherical nanoparticles being the best ionizing agent to use [148]. Finally, various imaging modalities (e.g., PTT) and other therapeutic approaches can be coupled to radiotherapy when using AuNMs, to improve the therapeutic outcome [149][150][151][152].…”

Section: High-intensity Focused Ultrasound Therapy (Hifu)mentioning

confidence: 99%

Latest advances in combining gold nanomaterials with physical stimuli towards new responsive therapeutic and diagnostic strategies

Movia

Benhaddada

Spadavecchia

et al. 2020

Precision Nanomedicine

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Graphical abstract KeywordsGold nanoparticle 1 ; external stimuli; physical stimuli; physically triggered nanomedicine. Quote this article as: Movia D, Benhaddada M, Jolanda Spadavecchia J, Prina-Mello A, Latest advances in combining gold nanomaterials with physical stimuli towards new responsive therapeutic and diagnostic strategies, Precis. Nanomed. 2020 April;3(2):495-524, https://doi. AbstractNanomedicine aims at enhancing treatment efficiency and/or improving diagnostic sensitivity by better controlling several critical parameters, such as tissue targeting and off-target toxicity. More recently, advanced nanomedicine products have been developed to achieve spatially and temporally controlled therapy and diagnosis. This review focuses on gold nanomaterials (AuNMs) and alloy/hybrid AuNMs that can be used in stimuli-responsive strategies for therapeutic and diagnostic applications. Endogenous and/or exogenous stimuli can be used as a trigger for such systems. Herein, we focus on those activated by exogenous stimuli. Our review starts from one specific externally activated product, Aurolase®, which recently underwent clinical studies. Further we continue describing a specific physically triggered category, for which the exogeneous stimulus applied induces a structural transformation or modification that is essential for their therapeutic and/or diagnostic action. Gold nanomaterials are grouped both by the nature of the function they exert (therapeutic or diagnostic) and the stimuli class.

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“…However, in the case of using protein molecule alone as the template, nanoparticle aggregation could be produced and it is difficult to synthesize ultrasmall metal particles in a controlled manner . Proteins with cage‐like structures can provide confined space for metal nanoparticle generation.…”

Section: Synthesis Of Enzyme–metal Hybrid Catalysts (Emhcs)mentioning

confidence: 99%