RGD peptide conjugated liposomal drug delivery system for enhance therapeutic efficacy in treating bone metastasis from prostate cancer

Wang, Fangfang; Chen, Lei; Zhang, Rui; Chen, Zhongping; Zhu, Li

doi:10.1016/j.jconrel.2014.10.012

Cited by 164 publications

(117 citation statements)

References 46 publications

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“…Its biocompatible structure and characteristics make it possible to be utilized as a drug delivery system [23][24][25]. Liposomes can encapsulate hydrophobic compounds inside its bilayer membrane and hydrophilic compound inside its core [21].…”

Section: Introductionmentioning

confidence: 99%

Simultant encapsulation of vitamin C and beta-carotene in sesame (Sesamum indicum l.) liposomes

Hudiyanti

Fawrin

Siahaan

2018

IOP Conf. Ser.: Mater. Sci. Eng.

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Abstract. In this study sesame liposomes were used to encapsulate both vitamin C and betacarotene simultaneously. Liposomes were prepared with addition of cholesterol. The encapsulation efficiency (EE) of sesame liposomes for vitamin C in the present of beta-carotene was 77%. The addition of cholesterol increased the encapsulation efficiency. The highest encapsulation efficiency was 89% obtained in liposomes with 10% and 20% cholesterol. Contrary to that, the highest beta-carotene encapsulation efficiency of 78%, was found in the sesame liposomes prepared without the added cholesterol. Results showed that sesame liposomes can be used to encapsulate beta-carotene and vitamin C simultaneously. When beta-carotene and vitamin C were encapsulated concurrently, cholesterol intensified the efficiency of vitamin C encapsulation on the contrary it diminished the efficiency of beta-carotene encapsulation.

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Section: Introductionmentioning

confidence: 99%

Simultant encapsulation of vitamin C and beta-carotene in sesame (Sesamum indicum l.) liposomes

Hudiyanti

Fawrin

Siahaan

2018

IOP Conf. Ser.: Mater. Sci. Eng.

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“…[168] To enhance therapeutic efficacy, an RGD peptide conjugated liposomal drug delivery system binding to type I collagen can be used. [169] If the side effects causing problems are because of the multifunctional character of CatK, that is, the protease cleaves a multitude of physiologically relevant substrates including extracellular non-matrix proteins, then an exosite inhibitor approach would be useful. Exosite inhibitors of CatK that specifically block the osteoporosis-relevant collagenase activity without affecting the hydrolysis of other substrates would circumvent the intrinsic problem of an active site-directed drug terminating the entire proteolytic activity of the target protease.…”

Section: Expert Opinionmentioning

confidence: 99%

Cathepsin K osteoporosis trials, pycnodysostosis and mouse deficiency models: Commonalities and differences

Brὂmme

Panwar

Turan

2016

Expert Opinion on Drug Discovery

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Several selective cathepsin K inhibitors have been developed and evaluated in preclinical and clinical studies. Although all compounds were effective in reducing bone resorption markers, the development of some compounds was terminated either due to side effects or market competition. The most advanced compound is odanacatib, which significantly reduced bone fracture rates in a 5-year trial but still exhibits safety concerns. The analysis of mouse and human catK deficiencies sheds some light on the consequences of a cathepsin K inhibitor treatment. How predictive the knockout phenotypes are regarding long-term cathepsin K treatment remains unclear. Clearly, more studies are needed to understand the mechanism of the observed side effects and novel approaches are needed to make CatK inhibitors either osteoclast-specific or selective for the inhibition of the collagen matrix without affecting the other activities of the protease.

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“…Targeted delivery of therapeutics may help reduce toxicity and increase efficacy. Recently, novel nanomaterials tagged with relevant targeting ligands have been developed to interact with receptors highly expressed in tumour tissues for safe and efficient delivery of therapeutic cargos in the treatment of prostate cancer [4] [5] [6] [7].…”

Section: Introductionmentioning

confidence: 99%

Bioconjugated gold nanoparticles enhance cellular uptake: A proof of concept study for siRNA delivery in prostate cancer cells

Guo

O’Driscoll

Holmes

et al. 2016

International Journal of Pharmaceutics

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RGD peptide conjugated liposomal drug delivery system for enhance therapeutic efficacy in treating bone metastasis from prostate cancer

Cited by 164 publications

References 46 publications

Simultant encapsulation of vitamin C and beta-carotene in sesame (Sesamum indicum l.) liposomes

Simultant encapsulation of vitamin C and beta-carotene in sesame (Sesamum indicum l.) liposomes

Cathepsin K osteoporosis trials, pycnodysostosis and mouse deficiency models: Commonalities and differences

Bioconjugated gold nanoparticles enhance cellular uptake: A proof of concept study for siRNA delivery in prostate cancer cells

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