RGD mimetics containing phthalimidine fragment as novel ligands of fibrinogen receptor

Krysko, Andrei A.; Samoylenko, Georgiy V.; Polishchuk, Pavel; Андронаті, С. А.; Kabanova, T. A.; Khristova, Tetiana M.; Кузьмин, В. Е.; Kabanov, V. M.; Krysko, Olga; Varnek, Alexandre; Grygorash, Ruslan

doi:10.1016/j.bmcl.2011.07.063

Cited by 5 publications

(2 citation statements)

References 38 publications

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“…Fibronectin is a cell‐surface and ECM glycoprotein, with the major cell‐binding sites being arginyl–glycyl–aspartic acid (RGD) sequences (Singh et al ., ). Other ECM proteins also bind RGD sequences (Barczyk et al ., ), including vitronectin (Maile et al ., ), type I І collagen (Taubenberger et al ., ) and fibrinogen (Sanchez‐Cortes and Mrksich, ; Krysko et al ., ). Despite the similarity of the RGD attachment sequence in the various cell adhesive molecules, cells can only recognize them individually through cell surface receptors (Ruoslahti, ).…”

Section: Discussionmentioning

confidence: 97%

Fibronectin stimulates the osteogenic differentiation of murine embryonic stem cells

Kang

Georgiou

Macfarlane

et al. 2015

J Tissue Eng Regen Med

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Conditioned medium from human hepatocarcinoma cells (HepG2-CM) has been shown to stimulate the osteogenic/chondrogenic differentiation of murine embryonic stem cells (mESCs). HepG2-CM is considered to contain visceral endoderm (VE)-like signals and attempts have recently been made to characterize it, using proteomic profiling, with fibronectin being identified as one promising candidate. Herein, we investigated whether fibronectin is able to mimic the activities of HepG2-CM during the osteogenic differentiation of mESCs. Specifically, the addition of RGD peptides and heparin in HepG2-CM significantly reduced the growth- and adhesion-promoting effects of HepG2-CM, in addition to suppressing its osteogenic-inductive activity. Furthermore, direct addition of fibronectin to basal medium was able to reproduce, at least partially, the function of HepG2-CM. In particular, fibronectin induced the early onset of osteogenic differentiation in mESCs, as confirmed by gene expression of osteogenic markers, and resulted in the three-fold higher calcium deposition at day 11 of osteogenic culture compared to the control group. These data clearly suggest that fibronectin contributes to the biological activities of HepG2-CM and plays a stimulatory role during the process of osteogenesis in mESCs. Copyright © 2015 John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 97%

Fibronectin stimulates the osteogenic differentiation of murine embryonic stem cells

Kang

Georgiou

Macfarlane

et al. 2015

J Tissue Eng Regen Med

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“…4.Why, during the configuration of isomerization, does the enantiomer not always pass through an achiral boundary? Antiviral activity, antimicrobial activity and antitumor activity Pharmacokinetic Parameter [25], [41][42][43][44][45] Affinity for different biological targets [46][47][48][49][50][51][52][53] Different types of toxicity [44], [54][55][56][57][58][59][60][61][62][63][64][65]…”

Section: The Methodology Of Sirmsmentioning

confidence: 99%

Simplex representation of molecular structure as universal QSAR/QSPR tool

et al. 2021

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We review the development and application of the Simplex approach for the solution of various QSAR/QSPR problems. The general concept of the simplex method and its varieties are described. The advantages of utilizing this methodology, especially for the interpretation of QSAR/QSPR models, are presented in comparison to other fragmentary methods of molecular structure representation. The utility of SiRMS is demonstrated not only in the standard QSAR/QSPR applications, but also for mixtures, polymers, materials, and other complex systems. In addition to many different types of biological activity (antiviral, antimicrobial, antitumor, psychotropic, analgesic, etc.), toxicity and bioavailability, the review examines the simulation of important properties, such as water solubility, lipophilicity, as well as luminescence, and thermodynamic properties (melting and boiling temperatures, critical parameters, etc.). This review focuses on the stereochemical description of molecules within the simplex approach and details the possibilities of universal molecular stereo-analysis and stereochemical configuration description, along with stereo-isomerization mechanism and molecular fragment “topography” identification.

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Tetrahydroisoquinolines

2018

Privileged Structures in Drug Discovery

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RGD mimetics containing phthalimidine fragment as novel ligands of fibrinogen receptor

Cited by 5 publications

References 38 publications

Fibronectin stimulates the osteogenic differentiation of murine embryonic stem cells

Fibronectin stimulates the osteogenic differentiation of murine embryonic stem cells

Simplex representation of molecular structure as universal QSAR/QSPR tool

Tetrahydroisoquinolines

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