“…Incorporation of RGD or polylysine (pK7) ligands on these locations led to enhancement of Ad infectivity to a wide variety of target cells (for example tumors cells and DCs) that overexpress integrins or HSPGs, respectively (Dmitriev et al, 1998;Koizumi et al, 2003;Wickham et al, 1996;Wu et al, 2002). Besides fiber knob, other capsid proteins such as hexon, penton, pIX or pIII have also been investigated to alter the vector tropism by cell-specific ligand incorporation Glasgow et al, 2006;Vellinga et al, 2004;Vigne et al, 1999;Wu et al, 2005). Utilizing affibodies or library screening approaches, cell-specific targeting ligands can be identified that can be incorporated to Ad capsid to form stable virions (Belousova et al, 2008;Henning et al, 2002;Nord et al, 1997).…”