RGD-functionalization of PLA/starch scaffolds obtained by electrospinning and evaluated in vitro for potential bone regeneration

Gutiérrez-Sánchez, Mariana; Escobar-Barrios, Vladimir Alonso; Pozos‐Guillén, Amaury; Escobar‐García, Diana María

doi:10.1016/j.msec.2018.12.003

Cited by 55 publications

(20 citation statements)

References 24 publications

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“…PLLA proved particularly effective in inducing positive outcomes in osteogenesis in vitro. Gutierrez-Sanchez and colleagues [151] functionalised PLA scaffolds through adsorption of a tripeptide moiety that facilitates cell adhesion. Similar adhesion results were seen by osteoblasts with or without the tripeptide functionalisation.…”

Section: Bioscaffolds For Cell Cultivation In Vitromentioning

confidence: 99%

Recent Advances in Bioplastics: Application and Biodegradation

et al. 2020

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The success of oil-based plastics and the continued growth of production and utilisation can be attributed to their cost, durability, strength to weight ratio, and eight contributions to the ease of everyday life. However, their mainly single use, durability and recalcitrant nature have led to a substantial increase of plastics as a fraction of municipal solid waste. The need to substitute single use products that are not easy to collect has inspired a lot of research towards finding sustainable replacements for oil-based plastics. In addition, specific physicochemical, biological, and degradation properties of biodegradable polymers have made them attractive materials for biomedical applications. This review summarises the advances in drug delivery systems, specifically design of nanoparticles based on the biodegradable polymers. We also discuss the research performed in the area of biophotonics and challenges and opportunities brought by the design and application of biodegradable polymers in tissue engineering. We then discuss state-of-the-art research in the design and application of biodegradable polymers in packaging and emphasise the advances in smart packaging development. Finally, we provide an overview of the biodegradation of these polymers and composites in managed and unmanaged environments.

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Section: Bioscaffolds For Cell Cultivation In Vitromentioning

confidence: 99%

Recent Advances in Bioplastics: Application and Biodegradation

et al. 2020

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“…Gutiérrez-Sánchez et al found a similar initial contact angle (135.64º ± 1.26º) for PCL, which after 5 min decreased by less than 8° due to its low wettability or hydrophobic character of the polymer. 32 For the PCL/PMS membrane, a hydrophobic behavior was observed, with average contact angles of 140.53° on the left side and 137.68° on the right side at 0 s. A significant reduction in angles was found at 60 s (p < 0.05) on both sides. Nonetheless, no significant differences were found between 60 s and 300 s (p = 0.28).…”

Section: Contact Anglementioning

confidence: 85%

“…In this membrane, a lower tendency to wetting over time may be due to the presence of the electrospun PMS, which is only slightly soluble in water. 32 In PCL/PMS membranes, the presence of PMS led to a more hydrophobic character compared to the pure PCL membranes, suggesting that hydrophobic interactions between the two polymers induces a greater hydrophobic behavior. 33 In the case of the PCL/β-glucan solution, the membrane had a contact angle statistically similar to PCL (p = 0.46).…”

Section: Contact Anglementioning

confidence: 92%

Ultrathin single and multiple layer electrospun fibrous membranes of polycaprolactone and polysaccharides

Rodríguez-Sánchez

Vergara-Villa

Clavijo-Grimaldo

et al. 2020

Journal of Bioactive and Compatible Polymers

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Electrospinning was used to produce fibrous membranes, in single and multiple layers, from poly(ε-caprolactone), pullulan, and from mixtures of poly(ε-caprolactone) with potato modified starch and β-glucan. It was possible to obtain single-layer membranes from solutions of pullulan in water, poly(ε-caprolactone) in chloroform, and from mixtures of poly(ε-caprolactone)/β-glucan and poly(ε-caprolactone)/potato modified starch in chloroform. Scanning electron microscopy images showed the formation of ultrathin homogeneous fibers from electrospun poly(ε-caprolactone) and pullulan, whereas the fibers obtained from mixtures of poly(ε-caprolactone)/ β -glucan and poly(ε-caprolactone)/potato modified starch had different sizes and morphologies, as well as irregular microstructures, characterized by the presence of beads. Contact angle analyses showed that pullulan membranes were extremely hydrophilic, while poly(ε-caprolactone) membranes were predominantly hydrophobic. Subsequently, poly(ε-caprolactone)-pullulan-poly(ε-caprolactone) multilayer membranes, with intermediate wettability, were prepared by successive electrospinning steps. Infrared spectroscopy and calorimetric analyses showed the presence of both polymers and the absence of changes in their structure and stability due to electrospinning, indicating adequate compatibility between the two polymers. We foresee that the polyester-polysaccharide multilayer membrane might be used as a biodegradable vehicle for active agents with different hydrophobicity, with applications as food packaging and biocompatible scaffold materials.

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“…Aliphatic polyesters, like polycaprolactone (PCL), PLGA, PLA, and others, have shown excellent properties for biomedical applications, mostly because they are biodegradable, biocompatible and promote cellular adhesion when they are mixed with ceramic fillers like hydroxyapatite or BG 30–34 . This kind of polyester's chemical structure helps their metabolism, but some show hydrophobicity, like the PLA, and surface treatment is usually required 33,35 . Also, as a potential consequence of processing, thermal degradation can derive into harmful products, and the presence of BG modifies the polyester‐based composites' thermal behavior 31 .…”

Section: Introductionmentioning

confidence: 99%

Thermal and mechanical properties of UHMWPE/HDPE/PCL and bioglass filler: Effect of polycaprolactone

Espinosa

Escobar-Barrios

Escobedo

et al. 2020

J of Applied Polymer Sci

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Polymeric composites based on polyethylene, high‐density polyethylene (HDPE) and ultra‐high‐molecular‐weight polyethylene (UHMWPE) with polycaprolactone (PCL) and a ceramic filler (bioglass type) were studied in terms of their thermal and mechanical behavior. Two polyethylene ratios (10/90 and 30/70% wt/wt of UHMWPE/HDPE) and two PCL content ratios (5% and 10% wt/wt) were used. The obtained composites were characterized by differential scanning calorimetry, melt flow index, Fourier transform infrared spectroscopy, scanning electron microscopy, and X‐ray diffraction. The results indicate a nonchemical interaction between polyethylene, especially the UHMWPE, and PCL and that the composites' thermal transitions vary from the parent polymers and depend on the PCL concentration. The PCL's melting temperature in the composite was reduced, showing a new one. Also, the melting enthalpy of polyethylene was reduced when the concentration of PCL increased. The mechanical behavior depends on both the polyethylene ratio and the PCL content. The composite with 30% wt/wt of UHMWPE and 10% wt/wt of PCL showed the highest toughness value due to the good interaction between polymers. These new composites may be attractive for biomedical applications and could be evaluated, for example, as materials for prostheses.

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RGD-functionalization of PLA/starch scaffolds obtained by electrospinning and evaluated in vitro for potential bone regeneration

Cited by 55 publications

References 24 publications

Recent Advances in Bioplastics: Application and Biodegradation

Recent Advances in Bioplastics: Application and Biodegradation

Ultrathin single and multiple layer electrospun fibrous membranes of polycaprolactone and polysaccharides

Thermal and mechanical properties of UHMWPE/HDPE/PCL and bioglass filler: Effect of polycaprolactone

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