RfaA (YqhY), a novel adaptor protein, controls metabolite-sensitive protein degradation
in Bacillus subtilis
Jorg Stulke,
Dennis Wicke,
Sabine Lentes
et al.
Abstract:The carboxylation of acetyl-CoA is the committed step of fatty acid synthesis catalyzed by the multisubunit acetyl-CoA carboxylase (ACCase). However, the mechanisms that control the activity of this enzyme are poorly understood. Here, we identify the so far unknown protein RfaA (YqhY) of the model bacterium Bacillus subtilis as a regulator of fatty acid acquisition that targets the AccC subunit of ACCase for degradation. RfaA interacts with both AccC and the ClpE unfoldase subunit of the ClpEP protease complex… Show more
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