RF07 | PSUN350 Estradiol Effects on Polymorphonuclear Cell Production and Actions Contribute to Estrogen-mediated Lymphangioleiomyomatosis (LAM) Progression
Abstract:Lymphangioleiomyomatosis (LAM) is a rare lung disease seen almost exclusively in female sexed individuals and characterized by slowly growing, metastatic smooth muscle cell-like adenomas that cause cyst formation in the lung parenchyma and irreversible loss of pulmonary function. Given the female specificity of disease manifestation, metastatic nature, and estrogen sensitivity of LAM cells, we previously proposed that LAM cells originate in the myometrium. Our subsequent reports showed that inactivation of TSC… Show more
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