RF-PSSM: A Combination of Rotation Forest Algorithm and Position-Specific Scoring Matrix for Improved Prediction of Protein-Protein Interactions Between Hepatitis C Virus and Human
Abstract:The identification of hepatitis C virus (HCV) virus-human protein interactions will not only help us understand the molecular mechanisms of related diseases but also be conductive to discovering new drug targets. An increasing number of clinically and experimentally validated interactions between HCV and human proteins have been documented in public databases, facilitating studies based on computational methods. In this study, we proposed a new computational approach, rotation forest position-specific scoring … Show more
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