Rezidivierende Hornhautulzera bei Morbus Crohn assoziiert mit Epidermolysis bullosa acquisita

Abstract

Corneal complications in patients with Crohn's disease are very rare in contrast to conjunctivitis, episcleritis und uveitis. To the best of our knowledge, this is the first description of a patient with Crohn's disease and epidermolysis bullosa acquisita developing progressive corneal ulcer. How closely an assumed autoimmune mechanism in the cornea is related to Crohn's disease or epidermolysis bullosa acquisita, is not known.

Necrotizing Keratitis after Laser Refractive Surgery in Patients with Inactive Inflammatory Bowel Disease

“…In comparison to the spondyloarthropathies, IBD patients were female and had uveitis that was bilateral, posterior, insidious in onset, or chronic in duration; episcleritis, scleritis, and glaucoma are also more common [8]. Other reported primary ocular complications are conjunctivitis, proptosis, idiopathic orbital inflammation, extraocular muscle pareses, myositis, orbital cellulitis, peripheral corneal ulcers, macular edema, central serous retinopathy, retrobulbar neuritis, optic neuropathies, bilateral neuroretinitis with secondary vitritis, subretinal fibrosis and panuveitis syndrome, multifocal choroiditis, and pars planitis [9, 10, 11, 12]. Secondary ocular complications in IBD are due to malnutrition and ileal resection.…”