2019
DOI: 10.2174/1386207322666190415100618
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Reynoutria Japonica from Traditional Chinese Medicine: A Source of Competitive Adenosine Deaminase Inhibitors for Anticancer

Abstract: Background:Adenosine deaminase (ADA) is an important enzyme in purine metabolism and is known as a potential therapeutic target for the treatment of lymphoproliferative disorders and cancer. Traditional Chinese Herbal Medicine (TCHM) is widely used alone or in combination with chemotherapy to treat cancer, due to its ability to deliver a broad variety of bioactive secondary metabolites as promising sources of novel organic natural agents.Objective:In the present study, 29 varieties of medicinal plants were scr… Show more

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Cited by 12 publications
(7 citation statements)
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“…To compare the in-silico theoretical study with practical data, the ADA enzyme was isolated from rat joints and assayed in the absence and presence of Fenugreek QUE. The ADA activity was inhibited in rat joints by Fenugreek QUE with an IC 50 value of 0.17 mM, whereas previous study reported that the IC 50 value of Reynoutria japonica which represented a natural inhibitor of ADA was 0.629 mM (Zhang et al 2019 ). The fenugreek QUE acts as a non-competitive inhibitor with a K i value of 55.5 mM.…”
Section: Discussionmentioning
confidence: 87%
“…To compare the in-silico theoretical study with practical data, the ADA enzyme was isolated from rat joints and assayed in the absence and presence of Fenugreek QUE. The ADA activity was inhibited in rat joints by Fenugreek QUE with an IC 50 value of 0.17 mM, whereas previous study reported that the IC 50 value of Reynoutria japonica which represented a natural inhibitor of ADA was 0.629 mM (Zhang et al 2019 ). The fenugreek QUE acts as a non-competitive inhibitor with a K i value of 55.5 mM.…”
Section: Discussionmentioning
confidence: 87%
“…Molecular docking analysis showed that emodin could bind to the active site of ADA tightly, which significantly protected cordycepin against degradation. The cytotoxic activity of cordycepin against leukemia K562 cells was strongly enhanced in combination with emodin in vitro (Zhang et al, 2019).…”
Section: Methods For Improving the Bioavailability And Efficacy Of Co...mentioning
confidence: 99%
“…The H-bond length between the ligand and protein residues was found to be in the range of 1.65 to 2.92 Å. Adenosine kinase inhibitors are known to possess anti-inflammatory, antinociceptive, and anticonvulsant activity in animal models. Recent reports on AK inhibitors suggest that the modification of the Adenosine kinase-mediated pathway has a potential role in cancer therapy [27][28][29]. GSK-3β plays a significant role in neurodegenerative diseases and diabetes, and has been investigated for the anticancer disease treatment strategies as well, where it has produced fruitful results [30][31][32].…”
Section: Molecular Dockingmentioning
confidence: 99%