Rey auditory-verbal learning test performance of patients with and without memory impairment

Rosenberg, Samuel; Ryan, Joseph J.; Prifitera, Aurelio

doi:10.1002/1097-4679(198405)40:3<785::aid-jclp2270400325>3.0.co;2-4

Cited by 169 publications

(97 citation statements)

References 2 publications

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“…The extensive battery of neuropsychological tests tested seven cognitive domains: general mental status, tested using the Mini-Mental-Status Examination-Chinese version (MMSE) [13]; episodic memory, tested using the Auditory Verbal Learning Test (AVLT) [14] and Rey-Osterrieth Complex Figure delay recall test (R-O delay) [15]; attention, tested using the Trail Values are mean ± standard deviation. The comparisons of demographics between the two groups were performed using t-tests.…”

Section: Neuropsychological Tests and Personal Information Questionnairementioning

confidence: 99%

Disrupted White Matter Network and Cognitive Decline in Type 2 Diabetes Patients

Zhang

Liu

et al. 2016

JAD

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Abstract. Type 2 diabetes mellitus is accompanied by cognitive impairment and is associated with an increased risk of dementia. Damage to brain structures such as white matter network disruption may underlie this cognitive disturbance. In the present study, 886 non-diabetic and 163 type 2 diabetic participants completed a battery of neuropsychological tests. Among them, 38 diabetic patients and 34 non-diabetic participants that matched the patients for age/sex/education received a magnetic resonance imaging-based diffusion tensor imaging. Then we calculated the topological properties of the white matter network using a graph theoretical method to investigate network efficiency differences between groups. We found that type 2 diabetic patients had inferior performances compared to the non-diabetic controls, in several cognitive domains involving executive function, spatial processing, memory, and attention. We also found that diabetic patients exhibited a disrupted topological organization of the white matter network (including the global network properties, i.e., network strength, global efficiency, local efficiency and shortest path length, and the nodal efficiency of the right rolandic operculum) in the brain. Moreover, those global network properties and the nodal efficiency of the right rolandic operculum both had positive correlations with executive function in the patient group. The results suggest that type 2 diabetes mellitus leads to an alteration in the topological organization of the cortical white matter network and this alteration may account for the observed cognitive decline.

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Section: Neuropsychological Tests and Personal Information Questionnairementioning

confidence: 99%

Disrupted White Matter Network and Cognitive Decline in Type 2 Diabetes Patients

Zhang

Liu

et al. 2016

JAD

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“…All of the participants received a battery of neuropsychological tests assessing general mental status and other cognitive domains, such as episodic memory, tested using the Auditory Verbal Learning Test (AVLT) (25) …”

Section: Neuropsychological Testingmentioning

confidence: 99%

White Matter Integrity Disruptions Associated With Cognitive Impairments in Type 2 Diabetic Patients

et al. 2014

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Type 2 diabetes mellitus (T2DM) is associated with a twofold increased risk of dementia and can affect many cognitive abilities, but its underlying cause is still unclear. In this study, we used a combination of a battery of neuropsychological tests and diffusion tensor imaging (DTI) to explore how T2DM affects white matter (WM) integrity and cognition in 38 T2DM patients and 34 age-, sex-, and education-matched normal control subjects. A battery of neuropsychological tests was used to assess a wide range of cognitive functions. Tract-based spatial statistics combined with region of interest-wise (ROI-wise) analysis of mean values of DTI metrics in ROIs was used to compare group differences of DTI metrics on WM skeletons to identify severely disrupted WM tracts in T2DM. We found that T2DM patients showed 1) various cognitive impairments, including executive function, spatial processing, attention, and working memory deficits; 2) widespread WM disruptions, especially in the whole corpus callosum, the left anterior limb of the internal capsule (ALIC.L), and external capsule (EC); and 3) a positive correlation between executive function and WM integrity in the ALIC.L and the left EC.In conclusion, T2DM patients show various cognitive impairments and widespread WM integrity disruptions, which we attribute to demyelination. Moreover, executive dysfunction closely correlates with WM abnormalities.Type 2 diabetes mellitus (T2DM) in the elderly is a major public health problem. In China, .20.4% of the elderly population has diabetes, among which T2DM accounts for ;90% (1). As a risk factor for cognitive decline, T2DM is associated with a twofold increased risk of dementia (2) and can affect a wide range of cognitive abilities (3,4). However, its underlying cause is still unclear.A number of studies were carried out to investigate the mechanisms of T2DM-induced dementia and attributed the cognition decline to cerebral microstructure impairments, which included gray matter (GM) and white matter (WM) destruction (5,6). Despite the importance of GM atrophy in T2DM, WM microstructure abnormalities played a distinct and irreplaceable role in cognition impairments induced by T2DM (7,8). WM has a vital role for transferring information between GM regions, and its efficiency depends on WM microstructural integrity (9). However, the relationship between WM microstructural changes and T2DM is debated and contradictory. Many studies suggested a close correlation between T2DM and WM lesion (WML) severity or progression (5,10), but others did not (11,12). This uncertainty could be partly due to the insufficient sensitivity of conventional MRI modalities in detecting subtle brain WM changes or assessing the severity of WM hyperintensities (WMH) (7).Diffusion tensor imaging (DTI), a new type of MRI, has been developed as a powerful noninvasive technique to investigate WM microstructures and integrity (13,14). Fractional anisotropy (FA) and mean diffusivity (MD)

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“…(1) memory, tested by the Auditory Verbal Learning (AVLT-delay recall; Rosenberg et al, 1984) and the Rey-Osterrieth Complex Figure tests (ROCF-delay recall, Tupler et al, 1995); (2) visuospatial ability and attention, tested by the ROCF-copy test (Tupler et al, 1995), the clockdrawing test (Ishiai et al, 1993) Koss et al, 1984).…”

Section: Neuropsychological Tests and Personal Information Questionnairementioning

confidence: 99%

Disrupted Frontoparietal Network Mediates White Matter Structure Dysfunction Associated with Cognitive Decline in Hypertension Patients

Liang

Chen

et al. 2015

Journal of Neuroscience

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Some previous reports have suggested that hypertension is a risk factor for dementia and cognitive impairments. Using behavioral data from 1007 elderly human subjects (405 hypertensive patients) of Han ethnicity from Beijing, China, the present study aimed to assess the effects of hypertension on cognitive performance and explore related neuronal changes via advanced resting-state functional magnetic resonance imaging and diffusion tensor imaging data from 84 of these subjects (44 hypertensive patients). Cognitively, we found that patients with hypertension showed decreased executive functions and attention compared with those with normotension in the large sample. In magnetic resonance imaging scan sample, using independent component analysis to examine the functional connectivity difference between the two groups, we found that the frontoparietal networks in the hypertensive group exhibited altered patterns compared with the control group, mainly in the inferior parietal lobe, left inferior frontal lobe, and precuneus. Using tract-based spatial statistics to investigate the between-group structural difference, we found that the hypertensive group showed significantly reduced integrity of white matter in the bilateral superior longitudinal fasciculus. Importantly, using the mediation analysis, we found that the functional connectivity of the frontoparietal networks mediates the impact of white matter on executive function in the hypertensive group. The results demonstrate that hypertension targets a specific pattern of cognitive decline, possibly due to deficits in the white matter and functional connectivity in frontal and parietal lobes. Our findings highlight the importance of brain protection in hypertension.

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Rey auditory-verbal learning test performance of patients with and without memory impairment

Cited by 169 publications

References 2 publications

Disrupted White Matter Network and Cognitive Decline in Type 2 Diabetes Patients

Disrupted White Matter Network and Cognitive Decline in Type 2 Diabetes Patients

White Matter Integrity Disruptions Associated With Cognitive Impairments in Type 2 Diabetic Patients

Disrupted Frontoparietal Network Mediates White Matter Structure Dysfunction Associated with Cognitive Decline in Hypertension Patients

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