“…Miniaturization and integration of diagnostic devices would allow rapid and reliable high-throughput chemical and biomedical imaging and analysis from a tiny amount of sample such as a fingerprick volume of blood [7,[26][27][28][29][30]. Optofluidics takes advantage of integrating microfluidics and microelectronic optical components onto the same platform [31,32]. Such a platform, with fluidics for sample delivery/capture and lensless optics for sensing and detection, can be applied to areas such as ultra wide-field cell monitoring array [14,33,34], digital in-line holography [35][36][37][38][39][40][41], optofluidic microscopy [42][43][44][45], and lensless on-chip microscopy [15,41,42,46].…”
Low-cost, robust, and user-friendly diagnostic capabilities at the point-of-care (POC) are critical for treating infectious diseases and preventing their spread in developing countries. Recent advances in micro-and nano-scale technologies have enabled the merger of optical and fluidic technologies (optofluidics) paving the way for cost-effective lensless imaging and diagnosis for POC testing in resource limited settings. Applications of the emerging lensless imaging technologies include detecting and counting cells of interest, which allows rapid and affordable diagnostic decisions. This review presents the advances in lensless imaging and diagnostic systems, and their potential clinical applications in developing countries. The emerging technologies are reviewed from a POC perspective considering cost-effectiveness, portability, sensitivity, throughput and ease of use for resource-limited settings.
“…Miniaturization and integration of diagnostic devices would allow rapid and reliable high-throughput chemical and biomedical imaging and analysis from a tiny amount of sample such as a fingerprick volume of blood [7,[26][27][28][29][30]. Optofluidics takes advantage of integrating microfluidics and microelectronic optical components onto the same platform [31,32]. Such a platform, with fluidics for sample delivery/capture and lensless optics for sensing and detection, can be applied to areas such as ultra wide-field cell monitoring array [14,33,34], digital in-line holography [35][36][37][38][39][40][41], optofluidic microscopy [42][43][44][45], and lensless on-chip microscopy [15,41,42,46].…”
Low-cost, robust, and user-friendly diagnostic capabilities at the point-of-care (POC) are critical for treating infectious diseases and preventing their spread in developing countries. Recent advances in micro-and nano-scale technologies have enabled the merger of optical and fluidic technologies (optofluidics) paving the way for cost-effective lensless imaging and diagnosis for POC testing in resource limited settings. Applications of the emerging lensless imaging technologies include detecting and counting cells of interest, which allows rapid and affordable diagnostic decisions. This review presents the advances in lensless imaging and diagnostic systems, and their potential clinical applications in developing countries. The emerging technologies are reviewed from a POC perspective considering cost-effectiveness, portability, sensitivity, throughput and ease of use for resource-limited settings.
“…On the same kind of fiber also an electric-arc induced LPG was demonstrated (Iredale, 2006). One year later, it was proposed a rewritable self-assembled LPG in air-core PBG fibers (Ozcana & Demircib, 2007). The LPGs were written by filling the air-core region of the fiber with a solution containing polystyrene microspheres.…”
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.