Rewiring yeast metabolism for producing 2,3-butanediol and two downstream applications: Techno-economic analysis and life cycle assessment of methyl ethyl ketone (MEK) and agricultural biostimulant production

Life Cycle Assessment of Microbial 2,3-Butanediol Production from Brewer’s Spent Grain Modeled on Pinch Technology

“…Similarly, a comparison of BDO production from 2G succinic acid and direct C6 sugar fermentation revealed a GW of 2.05–2.37 and 0.16–0.54 kg CO 2 eq where embedded biogenic carbon is considered as negative emissions . On the same lines, considering GHG emission during fermentation and the carbon sequestered in the fermentation solid residue as biogenic will further reduce the GW by 6.35 kg CO 2 eq for this study and the subsequent GHG emission will be comparable to Patel et al , …”

“…Similarly, a comparison of BDO production from 2G succinic acid and direct C6 sugar fermentation revealed a GW of 2.05−2.37 and 0.16−0.54 kg CO 2 eq where embedded biogenic carbon is considered as negative emissions. 12 On the same lines, considering GHG emission during fermentation and the carbon sequestered in the fermentation solid residue as biogenic will further reduce the GW by 6.35 kg CO 2 eq for this study and the subsequent GHG emission will be comparable to Patel et al 1,2 BDO production from cardoon lignocellulosic biomass 13 estimated a total emission of 2.82 kg CO 2 eq, where 1.94 kg of CO 2 eq was attributed to the cultivation phase, while the biorefinery phase contributed 0.813 kg CO 2 eq. Since the substrate was a lignocellulosic feedstock where significant inventory is utilized for its growth, the cultivation phase was the highest contributor to carbon footprint.…”

“…It is projected that the market for bio-based chemicals will reach around $128 billion with a market share of $14.5 billion for butanediol (BDO) alone . BDO is an emerging platform chemical widely used in cosmetics, food, pharmaceuticals, plasticizers, drugs, and softening agents. , Notably, various BDO derivates, like 1,3-butadiene, acetoin, and methyl ethyl ketone (MEK), also possess high commercial value. − Currently, BDO is commercially produced from fossil-derived crude oil. , The crude oil is non-renewable, fossil in origin and its continued use pose environmental burden. Hence, increasing concern and awareness among market players regarding the impending environmental issues associated with large-scale fossil-derived platform chemicals have led to exploring sustainable bio-based production routes.…”

“…Microbial production of BDO using natural and genetically modified species such as Enterobacter sp., Bacillus sp., Klebsiella sp., Saccharomyces sp., Paenibacillaceae sp., and Enterococcus sp. has already been reported. ,, The fermentative BDO production commonly utilizes 1G feedstocks (glucose) and 2G feedstocks such as corn stover, wheat straw, lignocellulosic biomass, etc. as substrates.…”

A hybrid deep learning framework driven by data and reaction mechanism for predicting sustainable glycolic acid production performance

“…The remaining 79% of trash accumulated in landfills or the natural environment is thrown out and deposited on refuse landfills or aquatic ecosystems 7 . The singularly inappropriate approach to plastic solid waste directly contributes to a surge in CO 2 emissions, 8,9 which in turn contributes to global warming and brings a grievous threat to the environment and health of living things on earth 10–12 . Worldwide, the development of degradable materials, 13–15 has become the “hot spot” to deal with the ecological and environmental problems caused by nondegradable plastics 16,17 …”