Rewiring of metabolic pathways in yeasts for sustainable production of biofuels

Maurya, Rupesh; Gohil, Nisarg; Nixon, Snovia; Kumar, Nilesh; Noronha, Santosh; Dhali, Debarun; Trabelsi, Heykel; Alzahrani, Khalid J.; Reshamwala, Shamlan M. S.; Awasthi, Mukesh Kumar; Ramakrishna, Suresh; Singh, Vijai

doi:10.1016/j.biortech.2023.128668

Cited by 11 publications

(6 citation statements)

References 87 publications

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“…Recently, genetic engineering strategies have been employed for the enhancement of biofuel production. Biodiesels, bioalcohols and isoprenoid-based biofuels are, nowadays, obtained by exploiting different genetically engineered yeasts, such as S. cerevisiae XUSE, S. cerevisiae SXA-R2P-E, S. cervisiae M1: kurdriavzevii NUPHS33, S. cerevisiae YG5C423, Yarrowia lipolytica, Cryptococcus curvatus and Rhodotorula toruloides (147)(148)(149)(150)(151)(152).…”

Section: Biofuelsmentioning

confidence: 99%

The future in the litter bin – bioconversion of food waste as driver of a circular bioeconomy

Razouk,

Tiganescu,

von Glahn

et al. 2024

Front. Nutr.

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Bioconversion of organic waste requires the development and application of rather simple, yet robust technologies capable of transferring biomass into energy and sustainable materials for the future. Food waste plays a significant role in this process as its valorisation reduces waste and at the same time avoids additional exploitation of primary resources. Nonetheless, to literally become “litterate”. extensive research into such robust large-scale methods is required. Here, we highlight some promising avenues and materials which fulfill these “waste to value” requirements, from various types of food waste as sustainable sources for biogas, bioethanol and biodiesel to fertilizers and antioxidants from grape pomace, from old-fashioned fermentation to the magic of anaerobic digestion.

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Section: Biofuelsmentioning

confidence: 99%

The future in the litter bin – bioconversion of food waste as driver of a circular bioeconomy

Razouk,

Tiganescu,

von Glahn

et al. 2024

Front. Nutr.

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“…Therefore, it is difficult to achieve large-scale production for fuel applications through direct extraction and isolation methods. In addition, slow plant growth and geographical limitations further restrict the extraction of terpenes from plant sources [43]. The microbial synthesis of terpenes provides an efficient and scalable alternative platform for the production of monoterpene and sesquiterpene fuels.…”

Section: Microbial Synthesis Of Monoterpene and Sesquiterpene Fuelsmentioning

confidence: 99%

Biosynthesis Progress of High-Energy-Density Liquid Fuels Derived from Terpenes

Liu,

Lin,

Han

et al. 2024

Microorganisms

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High-energy-density liquid fuels (HED fuels) are essential for volume-limited aerospace vehicles and could serve as energetic additives for conventional fuels. Terpene-derived HED biofuel is an important research field for green fuel synthesis. The direct extraction of terpenes from natural plants is environmentally unfriendly and costly. Designing efficient synthetic pathways in microorganisms to achieve high yields of terpenes shows great potential for the application of terpene-derived fuels. This review provides an overview of the current research progress of terpene-derived HED fuels, surveying terpene fuel properties and the current status of biosynthesis. Additionally, we systematically summarize the engineering strategies for biosynthesizing terpenes, including mining and engineering terpene synthases, optimizing metabolic pathways and cell-level optimization, such as the subcellular localization of terpene synthesis and adaptive evolution. This article will be helpful in providing insight into better developing terpene-derived HED fuels.

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“…lipolytica. Typically, acetyl-CoA is the metabolic precursor of multiple compounds, so that its content and availability are pivotal factors for diverse metabolite synthesis. − The inherent ability to synthesize remarkable levels of cytosolic acetyl-CoA makes Y. lipolytica a more promising platform for the biosynthesis of lipids, isoprenoids, and polyketides than E.…”

Section: Building Y Lipolytica Cell Factories: Solutions For Solving ...mentioning

confidence: 99%

Building Yarrowia lipolytica Cell Factories for Advanced Biomanufacturing: Challenges and Solutions

Sun,

Gao,

Lin

et al. 2023

J. Agric. Food Chem.

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Microbial cell factories have shown great potential for industrial production with the benefit of being environmentally friendly and sustainable. Yarrowia lipolytica is a promising and superior non-model host for biomanufacturing due to its cumulated advantages compared to model microorganisms, such as high fluxes of metabolic precursors (acetyl-CoA and malonyl-CoA) and its naturally hydrophobic microenvironment. However, although diverse compounds have been synthesized in Y. lipolytica cell factories, most of the relevant studies have not reached the level of industrialization and commercialization due to a number of remaining challenges, including unbalanced metabolic flux, conflict between cell growth and product synthesis, and cytotoxic effects. Here, various metabolic engineering strategies for solving the challenges are summarized, which is developing fast and extremely conducive to rational design and reconstruction of robust Y. lipolytica cell factories for advanced biomanufacturing. Finally, future engineering efforts for enhancing the production efficiency of this platform strain are highlighted.

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Rewiring of metabolic pathways in yeasts for sustainable production of biofuels

Cited by 11 publications

References 87 publications

The future in the litter bin – bioconversion of food waste as driver of a circular bioeconomy

The future in the litter bin – bioconversion of food waste as driver of a circular bioeconomy

Biosynthesis Progress of High-Energy-Density Liquid Fuels Derived from Terpenes

Building Yarrowia lipolytica Cell Factories for Advanced Biomanufacturing: Challenges and Solutions

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