Reward Value of Cigarette Smoking for Comparably Heavy Smoking Schizophrenic, Depressed, and Nonpatient Smokers

Spring, Bonnie; Pingitore, Regina; McChargue, Dennis E.

doi:10.1176/appi.ajp.160.2.316

Cited by 139 publications

(114 citation statements)

References 50 publications

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“…Our finding of a higher plasma cotinine level per cigarette smoked (cotinine/CPD ratio) is consistent with earlier studies that reported higher urinary, plasma and saliva cotinine levels (Olincy et al, 1997;Sacco et al, 2005;Strand and Nybäck, 2005;Williams et al, 2005) and greater reward value (Spring et al, 2003) in SS. Olincy et al (1997) found no differences between groups in urinary cotinine clearance, while Williams et al (2005) showed that the ratio of 3-hydroxycotinine (a metabolite of cotinine) to cotinine was not altered in SS suggesting increased nicotine intake rather than alterations in nicotine metabolism.…”

Section: Baseline Differencessupporting

confidence: 93%

“…However, we did note that SS consumed significantly more cigarettes than CS after overnight abstinence which is consistent with prior reports of enhanced reinforcement in SS (Spring et al, 2003). For all smokers, craving level increased with abstinence and decreased with reinstatement of smoking while plasma nicotine decreased with abstinence and increased with reinstatement.…”

Section: Effects Of Smoking Abstinence and Reinstatement On Smoking Msupporting

confidence: 90%

“…For example, Spring et al (2003) found that smokers with schizophrenia attributed greater benefits to smoking and believed that they would need more incentives to quit than controls. In addition, schizophrenia is associated with neurocognitive deficits in attention, executive function, and spatial working memory (Keefe et al, 1995;Park and Holzman, 1992) and patients may smoke at higher rates to remediate these deficits (Adler et al 1993;George et al, 2002a;Sacco et al, 2005;Smith et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of acute abstinence, reinstatement, and mecamylamine on biochemical and behavioral measures of cigarette smoking in schizophrenia

Weinberger

Sacco

Creeden

et al. 2007

Schizophrenia Research

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Background: Schizophrenics have higher rates of smoking than the general population, and more difficulty with smoking cessation. However, there has been little study of differences between schizophrenics and controls with respect to biochemical and behavioral indices of smoking. We compared smokers with schizophrenia (SS; n=27) and control smokers (CS; n=26) on smoking and psychiatric outcomes at baseline, during acute smoking abstinence and reinstatement, and with pretreatment using the nicotinic acetylcholine receptor (nAChR) antagonist mecamylamine (MEC) in a human laboratory setting. Methods:Biochemical (e.g., plasma nicotine) and behavioral (e.g., craving, withdrawal) outcomes were assessed at baseline, after overnight abstinence, and after smoking reinstatement during three consecutive test weeks. Each week, participants received one of three doses of MEC (0.0, 5.0, or 10.0 mg/day × 3 days) in a randomized, counterbalanced manner.

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Section: Baseline Differencessupporting

confidence: 93%

Section: Effects Of Smoking Abstinence and Reinstatement On Smoking Msupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of acute abstinence, reinstatement, and mecamylamine on biochemical and behavioral measures of cigarette smoking in schizophrenia

Weinberger

Sacco

Creeden

et al. 2007

Schizophrenia Research

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show abstract

“…According to these authors, the satisfaction of other criteria such as construct or discriminant validity may have heuristic value and are considered as desired but not essential for the model to provide important initial uses in both basic neurobiological research and drug discovery. Further, it is becoming clear that a more useful strategy may be to model single endophenotypic differences (ie one clearcut Altered sensitivity to drugs of abuse Increased rewarding effect of smoking 195,196 Behavioral studies using nicotine in mice Not tested…”

Section: Does the Paradigm Meet Validity Criteria?mentioning

confidence: 99%

In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice

2004

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The ability to modify mice genetically has been one of the major breakthroughs in modern medical science affecting every discipline including psychiatry. It is hoped that the application of such technologies will result in the identification of novel targets for the treatment of diseases such as depression and to gain a better understanding of the molecular pathophysiological mechanisms that are regulated by current clinically effective antidepressant medications. The advent of these tools has resulted in the need to adopt, refine and develop mouse-specific models for analyses of depression-like behavior or behavioral patterns modulated by antidepressants. In this review, we will focus on the utility of current models (eg forced swim test, tail suspension test, olfactory bulbectomy, learned helplessness, chronic mild stress, drug-withdrawal-induced anhedonia) and research strategies aimed at investigating novel targets relevant to depression in the mouse. We will focus on key questions that are considered relevant for examining the utility of such models. Further, we describe other avenues of research that may give clues as to whether indeed a genetically modified animal has alterations relevant to clinical depression. We suggest that it is prudent and most appropriate to use convergent tests that draw on different antidepressant-related endophenotypes, and complimentary physiological analyses in order to provide a program of information concerning whether a given phenotype is functionally relevant to depressionrelated pathology.

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“…In this group of patients a higher risk of dependence on nicotine is observed [11], as well as a more severe abstinence syndrome when trying to quit smoking [12]. This last phenomenon probably results from the fact that in schizophrenics there are, independent of metabolism, higher levels of nicotine and cotinine than in the blood of non-schizophrenics smoking the same amounts of cigarettes [13].…”

Section: Scope Of Phenomenonmentioning

confidence: 96%

The Characteristics of Nicotine Addiction Among Patients with Schizophrenia

Wojtyna¹,

Wiszniewicz²

2013

Mental Disorders - Theoretical and Empirical Perspectives

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Reward Value of Cigarette Smoking for Comparably Heavy Smoking Schizophrenic, Depressed, and Nonpatient Smokers

Cited by 139 publications

References 50 publications

Effects of acute abstinence, reinstatement, and mecamylamine on biochemical and behavioral measures of cigarette smoking in schizophrenia

Effects of acute abstinence, reinstatement, and mecamylamine on biochemical and behavioral measures of cigarette smoking in schizophrenia

In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice

The Characteristics of Nicotine Addiction Among Patients with Schizophrenia

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