Reward representations and reward-related learning in the human brain: insights from neuroimaging

O’Doherty, John P.

doi:10.1016/j.conb.2004.10.016

Cited by 1,257 publications

(1,004 citation statements)

References 60 publications

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“…Stable and flexible representations of values encoded in the caudate nucleus might be transmitted to the superior colliculi via different parts of the substantia nigra, in order to bias sensorimotor behaviors toward rewarded information. The reward signal may be then further sent to cortical brain regions, such as orbital and medial prefrontal cortices (O'Doherty, 2004) or the anterior cingulate gyrus (Bush et al, 2002;Chudasama et al, 2013) which act to integrate and utilize the reward signal to dynamically modify behavior and response selection.…”

Section: Role Of Dopaminergic Signalsmentioning

confidence: 99%

How motivation and reward learning modulate selective attention

Bourgeois

Chelazzi

Vuilleumier

2016

Progress in Brain Research

107

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Section: Role Of Dopaminergic Signalsmentioning

confidence: 99%

How motivation and reward learning modulate selective attention

Bourgeois

Chelazzi

Vuilleumier

2016

Progress in Brain Research

107

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“…By virtue of its extensive efferent connectivity from the VTA, the NAc is also key to the processing of reward-related signals. For instance, human imaging studies have shown a consistent activation of the NAc to the presence of many different types of reward such NeuroImage 60 (2012) [2169][2170][2171][2172][2173][2174][2175][2176][2177][2178][2179][2180][2181] as monetary gain (Knutson et al, 2001), pleasant taste (O'Doherty, 2004) and smiling faces (Spreckelmeyer et al, 2009). In general, neuroimaging studies suggest that many aspects of the findings related to reward pathway function and activity in animals also generalise to humans (Knutson and Cooper, 2005).…”

Section: Introductionmentioning

confidence: 99%

Changes in reward-related signals in the rat nucleus accumbens measured by in vivo oxygen amperometry are consistent with fMRI BOLD responses in man

et al. 2012

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a b s t r a c t a r t i c l e i n f oReal-time in vivo oxygen amperometry, a technique that allows measurement of regional brain tissue oxygen (O 2 ) has been previously shown to bear relationship to the BOLD signal measured with functional magnetic resonance imaging (fMRI) protocols. In the present study, O 2 amperometry was applied to the study of reward processing in the rat nucleus accumbens to validate the technique with a behavioural process known to cause robust signals in human neuroimaging studies. After acquisition of a cued-lever pressing task a robust increase in O 2 tissue levels was observed in the nucleus accumbens specifically following a correct lever press to the rewarded cue. This O 2 signal was modulated by cue reversal but not lever reversal, by differences in reward magnitudes and by the motivational state of the animal consistent with previous reports of the role of the nucleus accumbens in both the anticipation and representation of reward value. Moreover, this modulation by reward value was related more to the expected incentive value rather than the hedonic value of reward, also consistent with previous reports of accumbens coding of "wanting" of reward. Altogether, these results show striking similarities to those obtained in human fMRI studies suggesting the use of oxygen amperometry as a valid surrogate for fMRI in animals performing cognitive tasks, and a powerful approach to bridge between different techniques of measurement of brain function.

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“…Several decades of comparative research on reward processing have identified a mesolimbic network that responds to anticipated or received positive incentives (Olds and Milner, 1954), and recent neuroimaging research suggests that these findings generalize to humans (Knutson and Cooper, 2005;Montague and Berns, 2002;O'Doherty, 2004). This research has implicated the midbrain (Schultz, 1998) and its projection areas in the ventral striatum (especially the nucleus accumbens [NAcc]; Knutson et al, 2001), dorsal striatum Zald et al, 2004), orbitofrontal cortex (Rolls, 2004), and other areas of mesial prefrontal cortex (Knutson et al, 2003;Ramnani et al, 2004), in anticipating or receiving rewards from money to attractive pictures to pleasant tastes.…”

Section: Introductionmentioning

confidence: 99%

Valence and salience contribute to nucleus accumbens activation

Cooper¹,

Knutson²

2008

NeuroImage

231

176

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Different accounts of nucleus accumbens (NAcc) function have emphasized its role in representing either valence or salience during incentive anticipation. In an event-related FMRI experiment, we independently manipulated valence and salience by cuing participants to anticipate certain and uncertain monetary gains and losses. NAcc activation correlated with both valence and salience. On trials with certain outcomes, NAcc activation increased for anticipated gains and decreased for anticipated losses. On trials with uncertain outcomes, NAcc activation increased for both anticipated gains and losses but did not differ between them. These findings suggest that NAcc activation separately represents both valence and salience, consistent with its hypothesized role in appetitive motivation.

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Reward representations and reward-related learning in the human brain: insights from neuroimaging

Cited by 1,257 publications

References 60 publications

How motivation and reward learning modulate selective attention

How motivation and reward learning modulate selective attention

Changes in reward-related signals in the rat nucleus accumbens measured by in vivo oxygen amperometry are consistent with fMRI BOLD responses in man

Valence and salience contribute to nucleus accumbens activation

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