Reward-Related Neural Circuitry in Depressed and Anxious Adolescents: A Human Connectome Project

Auerbach, Randy P.; Pagliaccio, David; Hubbard, Nicholas A.; Frosch, Isabelle R.; Kremens, Rebecca; Cosby, Elizabeth A.; Jones, Robert J.; Siless, Viviana; Lo, Nicole; Henin, Aude; Hofmann, Stefan G.; Gabrieli, John D. E.; Yendiki, Anastasia; Whitfield-Gabrieli, Susan; Pizzagalli, Diego A.

doi:10.1016/j.jaac.2021.04.014

Cited by 35 publications

(34 citation statements)

References 99 publications

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“…Despite these findings, the more common approach within our field is to identify brain‐related differences—viewed only through this cross‐sectional snapshot—as deficits or abnormalities. To be clear, my own work has drawn similar tentative conclusions based on cross‐sectional structural and functional MRI assessments among depressed and anxious adolescents (Auerbach et al., 2022). We, like many other researchers, passively acknowledge that there are developmentally sensitive periods, which may have profound effects on biobehavioral markers of interest, but our study designs are not necessarily equipped to characterize this effect.…”

Section: Rdoc: Where Are We Going?mentioning

confidence: 69%

RDoC and the developmental origins of psychiatric disorders: How did we get here and where are we going?

Auerbach

2022

Child Psychology Psychiatry

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About a decade ago, the National Institute of Mental Health (NIMH) proposed an innovative framework, the Research Domain Criteria (RDoC), to classify psychiatric disorders, which offered a complementary approach to use with existing diagnostic systems to identify transdiagnostic factors that inform early detection of mental health disturbances and critically provide novel targets for interventions, particularly those cutting across traditional diagnostic boundaries. Historically, the tendency in psychiatric research and biomedical research more generally is to initially develop adult-oriented models and then, after testing and refinement, downwardly extend these frameworks to youth populations (Rutter, 2008). Central to the RDoC initiative, however, is the goal of clarifying developmental processes and illness trajectories by operationalizing dimensional constructs during sensitive periods of neurofunctional development to capture the early emergence of behavioral alterations and impairment and, accordingly, to identify psychological, biological, molecular, and genomic markers associated with psychiatric disorders across the lifespan. As developmental factors are inherent to all RDoC systems and the units of analysis therein, NIMH shepherded developmental-oriented research with targeted funding opportunity announcements-with this resulting work highlighting promising phenotypes and biological markers related to psychiatric illness.

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Section: Rdoc: Where Are We Going?mentioning

confidence: 69%

RDoC and the developmental origins of psychiatric disorders: How did we get here and where are we going?

Auerbach

2022

Child Psychology Psychiatry

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“…There are a number of neuroanatomical landmarks implicated in the DMN (e.g., MPFC, PCC, angular gyrus, etc.) and our seed-based analysis approach privileged the sgACC as it shows specific alterations in MDD, including reduced glial cell count (61), abnormal blood flow and metabolism (62,63), abnormal thickness (64,65), reduced volume (61,62,66), and structural connectivity (67–69). Consistent with previous research, our sgACC-based functional connectivity findings suggest that the sgACC is a special hub in depression pathology and treatment.…”

Section: Discussionmentioning

confidence: 99%

Targeting default mode network connectivity with mindfulness-based fMRI neurofeedback: A pilot study among adolescents with affective disorder history

Zhang

Raya

Morfini

et al. 2022

Preprint

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Adolescents experience alarmingly high rates of major depressive disorder (MDD), however, gold-standard treatments are only effective for ~50% of youth. Accordingly, there is a critical need to develop novel interventions, particularly ones that target neural mechanisms believed to potentiate depressive symptoms. Directly addressing this gap, we developed a mindfulness-based fMRI neurofeedback (mbNF) for adolescents that targets default mode network (DMN) hyperconnectivity, which has been implicated in the onset and maintenance of MDD. In this proof-of-concept study, adolescents (n = 9) with a lifetime history of depression and/or anxiety were administered clinical interviews and self-report questionnaires, and then, each participant's DMN and central executive network (CEN) were personalized using a resting state fMRI localizer. After the localizer scan, adolescents completed a brief mindfulness training followed by a mbNF session in the scanner wherein they were instructed to volitionally reduce DMN relative to CEN activation by practicing mindfulness meditation. Several promising findings emerged. First, mbNF successfully engaged the target brain state during neurofeedback; participants spent more time in the target state with DMN activation lower than CEN activation. Second, in each of the nine adolescents, mbNF led to significantly reduced within-DMN connectivity, which correlated with post-mbNF increases in state mindfulness. Last, a reduction of within-DMN connectivity mediated the association between better mbNF performance and increased state mindfulness. These findings demonstrate that personalized mbNF can effectively and non-invasively modulate the intrinsic networks known to be associated with the emergence and persistence of depressive symptoms during adolescence.

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“…Reduced self-reported and task-measured reward sensitivity predict heightened internalizing symptoms (Alloy et al, 2016;Taubitz et al, 2015;Whitton et al, 2015), patterns that are mirrored by neuroimaging data (Luking et al, 2016). In particular, heightened internalizing symptoms have been associated with attenuated activity within the ventral and dorsal striatum (i.e., nucleus accumbens, caudate, and putamen) during reward anticipation and feedback (Auerbach et al, 2021;Pizzagalli et al, 2009a;Rappaport et al, 2020;Zhang et al, 2013) in adults and older adolescents (Auerbach et al, 2021;Forbes, 2011;Forbes et al, 2009Forbes et al, , 2010Luking et al, 2016;Morgan et al, 2013;Nielson et al, 2021). Similarly, reward-related activity within the orbitofrontal cortex (OFC) has been linked to negative emotion biases evident in internalizing disorders (Dichter et al, 2012b;Downar, 2019;McCabe et al, 2012;Rolls, 2016Rolls, , 2019Ubl et al, 2015).…”

Section: Introductionmentioning

confidence: 85%

Reward sensitivity and internalizing symptoms during the transition to puberty: An examination of 9-and 10-year-olds in the ABCD Study

McNeilly¹,

Saragosa-Harris

Mills³

et al. 2021

Preprint

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Early pubertal timing has been linked to increased risk for internalizing disorders. Work in older adolescents and adults suggests that heightened reward sensitivity may buffer risk for internalizing symptoms, but few studies have investigated these associations during the early transition to puberty, a window of vulnerability to mental health risk. In this preregistered study, we investigated the associations among pubertal timing, internalizing symptoms, and reward sensitivity in 11,243 9-10 year-olds from the Adolescent Brain Cognitive Development (ABCD) Study®. Using split-half analysis, we tested hypothesized effects across two subsets of the sample (Sample 1 N=5,631 ; Sample 2 N=5,612). Across samples, early pubertal timing was associated with higher internalizing symptoms in females and males, with highest symptoms evident in mid-pubertal adolescents. Additionally, early pubertal timing was robustly associated with greater self-reported reward sensitivity in both females and males. We observed preliminary evidence of a moderating role of self-reported and neural reward sensitivity in the association between early pubertal timing and internalizing symptoms, but several of these effects differed by sex, and no moderation effects replicated across samples. Together, these findings provide novel insights into early indicators of risk for internalizing disorders during the transition to puberty.

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Reward-Related Neural Circuitry in Depressed and Anxious Adolescents: A Human Connectome Project

Cited by 35 publications

References 99 publications

RDoC and the developmental origins of psychiatric disorders: How did we get here and where are we going?

RDoC and the developmental origins of psychiatric disorders: How did we get here and where are we going?

Targeting default mode network connectivity with mindfulness-based fMRI neurofeedback: A pilot study among adolescents with affective disorder history

Reward sensitivity and internalizing symptoms during the transition to puberty: An examination of 9-and 10-year-olds in the ABCD Study

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