Reward processing in adolescents with social phobia and depression

Luckhardt, Christina; Mühlherr, Andreas M.; Schütz, Magdalena; Jarczok, Tomasz A.; Jungmann, Stefanie M.; Howland, Vanessa; Veit, Lisa; Althen, Heike; Freitag, Christine M.

doi:10.1016/j.clinph.2023.03.356

Cited by 1 publication

(4 citation statements)

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“…This finding is also in agreement with previous reports, reinforcing the notion of altered anticipatory neural processes in MDD. 14,32,44 Of note, intriguingly, a preceding win feedback exhibited the ability to enhance the SPN in both groups, and this effect remained unaffected by consecutive gains. This implies that individuals with MDD may retain the capacity, to some extent, for heightened anticipatory neural processes.…”

Section: Discussionmentioning

confidence: 83%

“…This convergence of findings lends support that individuals with MDD encompassing anhedonia in both consumption and anticipation. 14 This could potentially hold clinical value, particularly in distinguishing MDD from conditions like schizophrenia, as prior research has indicated that individuals with schizophrenia predominantly manifest anhedonia during the anticipation phase. 34,35 Interestingly, our data did not show evident correlations between the ERP metrics and any of the TEPS domains in either the HC or MDD groups.…”

Section: Discussionmentioning

confidence: 99%

“…12,13 Some studies have also reported significant differences in SPN amplitudes between individuals with depression and healthy controls. 14 In general, these studies can offer valuable insights into the neurobiological mechanisms underlying anhedonia in MDD. Worth noting is that results of previous studies are not always consistent.…”

Section: Introductionmentioning

confidence: 99%

“…Worth noting is that results of previous studies are not always consistent. 15 For example, Christina Luckhardt et al discovered a correlation between MDD symptoms and smaller SPN, 14 whereas another study identified an increased SPN in participants with high levels of depression. 16 The inconsistencies may be due to differences in study methodologies, participant characteristics, and the specific nature of the tasks used to elicit the FRN and/or SPN response, which also illustrates the need to further explore the characteristics of FRN and SPN in patients with MDD.…”

Section: Introductionmentioning

confidence: 99%

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Neural Correlates of Anhedonia in Major Depressive Disorder: Insights from Concurrent Analysis of Feedback-Related Negativity and Stimulus-Preceding Negativity

Sun,

Huang,

Gao

et al. 2023

NDT

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Purpose: Anhedonia, a core symptom of major depressive disorder (MDD), is explored in this study, focusing on the neural underpinnings through the examination of two event-related potential (ERP) components: feedback-related negativity (FRN) and stimulus-preceding negativity (SPN). Patients and Methods: This cross-sectional study was conducted in China from March 2022 to March 2023. It involved 35 MDD patients and 31 healthy controls (HC) participating in a modified 2-door task with simultaneous EEG recordings. Depression severity and anhedonia were assessed using the Hamilton Depression Scale (HAMD) and the Temporal Experience of Pleasure Scale (TEPS-CV), respectively. FRN and SPN metrics, along with correlations with each other and clinical assessments, were examined. Results: In comparison to the HC group, the MDD group exhibited significantly lower scores in TEPS-CV (t = 2.854, p = 0.006) and its subscales (t = −3.596, p = 0.001 and t = 2.434, p = 0.018, respectively), along with consistently reduced amplitudes of FRN (F 1.64= 4.726, p = 0.033) and SPN (F 1.64= 4.195, p = 0.045) across all conditions. Limited correlations were observed between ERP metrics and clinical indicators, except for positive correlations between FRN amplitudes (loss minus win) and HAMD scores (r = 0.392, p = 0.020), and SPN amplitudes after losing (SPN-L) and TEPS-CV consumption subscale scores (r = 0.357, p = 0.035). Notably, while the HC group displayed no significant FRN-SPN correlations, the MDD group exhibited positive FRN-SPN correlations under distinct conditions (r = 0.376, p = 0.026 and r = 0.355, p = 0.037, respectively). Conclusion: Our data reveal subjective and objective anhedonia in both consumption and anticipation, suggesting a shared impairment in reward feedback processing and anticipatory neural mechanisms in individuals with MDD. These findings deepen our understanding of anhedonia's neural foundations and may guide targeted interventions for this core symptom.

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Section: Discussionmentioning

confidence: 83%