Reward processing electrophysiology in schizophrenia: Effects of age and illness phase

Abram, Samantha V.; Roach, Brian; Holroyd, Clay B.; Paulus, Martin P.; Ford, Judith M.; Mathalon, Daniel H.; Fryer, Susanna L.

doi:10.1016/j.nicl.2020.102492

Cited by 12 publications

(8 citation statements)

References 105 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, there appear to be deficits in the sustained processing of unpleasant stimuli in psychosis, and potentially to a lesser extent for pleasant stimuli, which may reflect a deficit in underlying motivational systems that naturally direct and sustain attention to threatening and/or appetitive environmental cues. Indeed, abnormal LPP amplitude in response to reward outcome processing (e.g., wins vs. losses) has been observed in patients with schizophrenia (Abram et al, 2020). Notably, the neural regions involved in purportedly generating the LPP (e.g., amygdala, prefrontal cortex, insula; Hajcak & Foti, 2020; Liu et al, 2012; Sabatinelli et al, 2007, 2013) overlap heavily with neural regions that are consistently found to exhibit reduced activity in patients with psychosis using similar paradigms (Anticevic et al, 2012; Taylor et al, 2012).…”

Section: Emotion Processing Impairment In Psychosismentioning

confidence: 99%

Clinical high risk for psychosis syndrome is associated with reduced neural responding to unpleasant images.

Osborne,

Zhang,

Gupta

et al. 2023

Journal of Psychopathology and Clinical Science

View full text Add to dashboard Cite

Deficits in emotion processing are core features of psychotic disorders. Electrophysiology research in schizophrenia suggests deficits in sustained engagement with emotional content (indexed by the late positive potential [LPP]) may contribute to emotion processing impairments. Despite similar behavioral emotion processing dysfunction in those at clinical high risk (CHR) for psychosis, limited research has examined neural mechanisms of impaired emotion processing in the high-risk period, where research can inform risk models. To examine mechanisms of emotion processing deficits in those at CHR for psychosis, the present study used a passive viewing task to elicit the LPP in response to emotionally engaging and neutral stimuli in 28 CHR and 32 control participants (60% female). Relative to controls, CHR participants showed reduced LPP amplitude when viewing unpleasant images (d = 0.75, p = .005) but similar LPP amplitude in response to both neutral (d = 0.35, p = .19) and pleasant images (d = 0.31, p = .24). This pattern suggests that individuals at CHR for psychosis exhibit a deficit in sustained engagement with unpleasant stimuli. Clinical and trait questionnaires were administered to examine potential exploratory explanations for group differences in LPP amplitude. Consistent with evidence suggesting LPP amplitude reflects engagement of approach/avoidance motivational systems, greater LPP amplitude was associated with greater trait-level behavioral avoidance in control participants (r = .42, p = .032) but not CHR participants (r = -.21, p = .40). Together, the present research is consistent with LPP studies in psychosis and implicates reduced sustained engagement with emotional content in the high-risk period.

show abstract

Section: Emotion Processing Impairment In Psychosismentioning

confidence: 99%

Clinical high risk for psychosis syndrome is associated with reduced neural responding to unpleasant images.

Osborne,

Zhang,

Gupta

et al. 2023

Journal of Psychopathology and Clinical Science

View full text Add to dashboard Cite

show abstract

“…23,24 Increasing evidence suggests that SCH may not be able to use prospective rewards to modulate subsequent targeted behavior due to dopaminergic transmission disturbances in the frontostriatal regions. 25 Yet, recent studies did not demonstrate the alteration of reward-related P300 in patients, 17,26 despite the existence of an association between P300 and negative symptoms in patients. 27,28 The monetary incentive delay (MID) task is an effective experimental paradigm to evaluate neural activity which includes reward and loss anticipation and outcome 29 in SCH.…”

Section: Introductionmentioning

confidence: 97%

“…While the responses to those cues in the reward condition maximize gains, they minimize the losses in the punishment condition. 26,31 Recent advances in understanding the motivational impairments in schizophrenia in the field of neuroscience offer a promising area. 32 Nevertheless, there is still a lack of studies searching for the neural correlates of anticipatory and consummatory facets of anhedonia in schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

“…While the responses to those cues in the reward condition maximize gains, they minimize the losses in the punishment condition. 26,31…”

Section: Introductionmentioning

confidence: 99%

“…It was hypothesized that compared with the healthy control, the patient group would have altered mean amplitudes and latencies of P300 during the loss (ie, punishment condition) in the MID task since earlier studies failed to show any differences between the groups during reward processing. 17,26…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Enhanced Punishment Responses in Patients With Schizophrenia: An Event-Related Potential Study

et al. 2023

View full text Add to dashboard Cite

It is well known that abnormal reward processing is a characteristic feature of various psychopathologies including schizophrenia. Reduced reward anticipation has been suggested as a core symptom of schizophrenia. The Monetary Incentive Delay Task (MID) is frequently used to detect reward anticipation. The present study aims to evaluate the amplitude and latency of event-related potential (ERP) P300 in patients with schizophrenia (SCH) compared to healthy controls during the MID task. Twenty patients with SCH and 21 demographically matched healthy controls (HC) were included in the study. ERP P300 amplitude and latency values were compared between groups using an MID task in which reward and loss cues were presented. Relations between P300 and clinical facets were investigated in the patient group. SCH group had enhanced mean P300 amplitudes and delayed peak latency in the punishment condition compared with HC. These higher responses were also associated with negative symptoms. SCH group showed altered reward processing as being more sensitive to loss of reward conditions as firstly evidenced by electrophysiological methods, possibly due to abnormality in various systems including social withdrawal, social defeat, and behavioral inhibition system.

show abstract

Reduced Reward Processing in Schizophrenia: A Comprehensive EEG Event-Related Oscillation Study

Akgül,

Fide,

Özel

et al. 2023

Brain Topogr

View full text Add to dashboard Cite

Reward processing electrophysiology in schizophrenia: Effects of age and illness phase

Cited by 12 publications

References 105 publications

Clinical high risk for psychosis syndrome is associated with reduced neural responding to unpleasant images.

Clinical high risk for psychosis syndrome is associated with reduced neural responding to unpleasant images.

Enhanced Punishment Responses in Patients With Schizophrenia: An Event-Related Potential Study

Reduced Reward Processing in Schizophrenia: A Comprehensive EEG Event-Related Oscillation Study

Contact Info

Product

Resources

About