Reward network dysfunction is associated with cognitive impairment after stroke

Wagner, Franziska; Rogenz, Jenny; Opitz, Laura; Maas, Johanna; Schmidt, A. A.; Brodoehl, Stefan; Ullsperger, Markus; Klingner, Carsten M.

doi:10.1016/j.nicl.2023.103446

Cited by 1 publication

(1 citation statement)

References 140 publications

(179 reference statements)

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“…Motivation plays a critical role in driving engagement and adherence to rehabilitation programs. Stroke survivors may face various barriers to motivation, including frustration, lack of interest, and perceived lack of progress (5,6). Providing meaningful incentives and rewards has been shown to enhance motivation and promote active participation in rehabilitation activities.…”

Section: Introductionmentioning

confidence: 99%

Improving rehabilitation motivation and motor learning ability of stroke patients using different reward strategies: study protocol for a single-center, randomized controlled trial

Zhao,

Guo,

Chen

et al. 2024

Front. Neurol.

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BackgroundStroke survivors often face challenges in motor learning and motivation during rehabilitation, which can impede their recovery progress. Traditional rehabilitation methods vary in effectiveness, prompting the exploration of novel approaches such as reward strategies. Previous research indicates that rewards can enhance rehabilitation motivation and facilitate motor learning. However, most reward paradigms have utilized fixed reward amounts, which also have limitations. Exploring alternative, more effective reward strategies, such as probabilistic rewards, is warranted to optimize stroke patient rehabilitation.MethodsA total of 81 stroke patients will be recruited and randomly assigned to control, fixed reward, or probabilistic reward groups at a ratio of 1:1:1 using a randomized number table method. Participants will undergo 10 days of daily hand motor function rehabilitation training, with sessions lasting 20 min each. The training will involve pegboard tests and box and block tests. Control group participants will receive standard training, while fixed reward group members will receive monetary incentives for completing tests, and probabilistic reward group members will have the chance to win monetary rewards through a lottery box. Rehabilitation motivation and motor performance and functional near-infrared spectroscopy brain imaging will be conducted at designated time points. The primary outcome measure is the stroke rehabilitation motivation scale, and the second outcome measures include motor performance, simple test for evaluating hand function, motivation and pleasure scale self-report, and Pittsburgh rehabilitation participation scale.DiscussionReward-based training enhance rehabilitation participation and adherence, it also improve motor learning speed and memory retention of stroke patients. The fixed reward applied in the past studies could diminish the sensitivity of stroke patients to rewards, while probabilistic reward may provide unpredictable or variable incentives or reinforcements for motor rehabilitation. This study will compare the efficacy of different reward strategies in enhancing motor learning ability and rehabilitation motivation among stroke patients. By conducting a randomized controlled trial, the study seeks to provide valuable insights into optimizing stroke rehabilitation protocols and improving patient outcomes.Clinical Trial Registration:https://www.chictr.org.cn/, ChiCTR2400082419.

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Section: Introductionmentioning

confidence: 99%