Reward Inhibits Paraventricular CRH Neurons to Relieve Stress

Yuan, Yuan; Wú, Wéi; Chen, Ming; Cai, Fang; Fan, Chengyu; Shen, Wei; Sun, Wenzhi; Hu, Ji

doi:10.1016/j.cub.2019.02.048

Cited by 117 publications

(118 citation statements)

References 52 publications

(59 reference statements)

Supporting

Mentioning

104

Contrasting

Order By: Relevance

“…Thus, CRF neurons in the PVN could work as an "interface" to transmit circadian information from the SCN to other brain areas and/or organs that temporally regulate physiological functions. It is also reported that CRF neurons in the PVN exhibited burst firings (37). In the present study, we observed calcium spikes in CRF neurons in the PVN, which was regulated by the GABAergic neurons in the SCN.…”

Section: Discussionsupporting

confidence: 76%

The mammalian circadian pacemaker regulates wakefulness via CRF neurons in the paraventricular nucleus of the hypothalamus

et al. 2020

View full text Add to dashboard Cite

In mammals, the daily rhythms of physiological functions are timed by the central circadian clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus. Although the importance of the SCN for the regulation of sleep/wakefulness has been suggested, little is known about the neuronal projections from the SCN, which regulate sleep/wakefulness. Here, we show that corticotropin-releasing factor (CRF) neurons in the hypothalamic paraventricular nucleus mediate circadian rhythms in the SCN and regulate wakefulness. Optogenetic activation of CRF neurons promoted wakefulness through orexin/hypocretin neurons in the lateral hypothalamus. In vivo Ca2+ recording showed that CRF neurons were active at the initiation of wakefulness. Furthermore, chemogenetic suppression and ablation of CRF neurons decreased locomotor activity and time in wakefulness. Last, a combination of optical manipulation and Ca2+ imaging revealed that neuronal activity of CRF neurons was negatively regulated by GABAergic neurons in the SCN. Our findings provide notable insights into circadian regulation of sleep/wakefulness in mammals.

show abstract

Section: Discussionsupporting

confidence: 76%

The mammalian circadian pacemaker regulates wakefulness via CRF neurons in the paraventricular nucleus of the hypothalamus

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Recent studies have shown that PVN-CRH neurons are able to respond differentially to stimuli with positive or negative valence (Kim et al, 2019; Yuan et al, 2019). Using in vivo fiber photometry to monitor population calcium dynamics, Kim et al (2019) have shown that the activity of PVN-CRH neurons rapidly increases in response to stimuli with negative valence, and decreases when an appetitive stimulus such as food or social interaction is presented.…”

Section: Role Of Hypothalamic Corticotropin (Pvn-crh) Neurons In Strementioning

confidence: 99%

Neurobiological links between stress and anxiety

Daviu

Bruchas

Moghaddam

et al. 2019

Neurobiology of Stress

299

187

View full text Add to dashboard Cite

Stress and anxiety have intertwined behavioral and neural underpinnings. These commonalities are critical for understanding each state, as well as their mutual interactions. Grasping the mechanisms underlying this bidirectional relationship will have major clinical implications for managing a wide range of psychopathologies. After briefly defining key concepts for the study of stress and anxiety in pre-clinical models, we present circuit, as well as cellular and molecular mechanisms involved in either or both stress and anxiety. First, we review studies on divergent circuits of the basolateral amygdala (BLA) underlying emotional valence processing and anxiety-like behaviors, and how norepinephrine inputs from the locus coeruleus (LC) to the BLA are responsible for acute-stress induced anxiety. We then describe recent studies revealing a new role for mitochondrial function within the nucleus accumbens (NAc), defining individual trait anxiety in rodents, and participating in the link between stress and anxiety. Next, we report findings on the impact of anxiety on reward encoding through alteration of circuit dynamic synchronicity. Finally, we present work unravelling a new role for hypothalamic corticotropin-releasing hormone (CRH) neurons in controlling anxiety-like and stress-induce behaviors. Altogether, the research reviewed here reveals circuits sharing subcortical nodes and underlying the processing of both stress and anxiety. Understanding the neural overlap between these two psychobiological states, might provide alternative strategies to manage disorders such as post-traumatic stress disorder (PTSD).

show abstract

“…Surgical procedures generally followed those from previous studies [26,27]. Briefly, mice were anesthetized by intraperitoneal injection of pentobarbital (100 mg/kg), kept warm (37°C) with an electric heating pad (BrainKing Biotech), and mounted in a stereotaxic holder in order to adjust their skulls to be parallel with the reference panel.…”

Section: Viral Micro-injection and Stereotaxic Surgerymentioning

confidence: 99%

“…We established intraoral cheek fistulae according to the procedure described previously [27][28][29]. Briefly, the first incision was made in the lateral cheek and another incision was made in the scalp near the ceramic ferrules.…”

Section: Viral Micro-injection and Stereotaxic Surgerymentioning

confidence: 99%

“…DF/F values were presented with heatmaps or average plots with a shaded area indicating the SEM. We used paired t test to analyze the statistical significance of the eventrelated fluorescence change as described elsewhere [27] and P < 0.05 was considered to be significant in these experiments. To calculate the average response and activation duration of DF/F values, we first segmented the data based on the behavioral events and baseline phase.…”

Section: Fiber Photometrymentioning

confidence: 99%

See 1 more Smart Citation