Reward functioning in posttraumatic stress and substance use disorders

Vujanovic, Anka A.; Wardle, Margaret C.; Smith, Lia J.; Berenz, Erin C.

doi:10.1016/j.copsyc.2016.11.004

Cited by 29 publications

(18 citation statements)

References 50 publications

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“…Anhedonia, or the inability to experience pleasure, emerges in some people in the aftermath of psychological trauma. Anhedonia is a transdiagnostic phenomenon that is observed across various psychiatric disorders, including depression, PTSD, and schizophrenia (Krynicki et al, 2018;Lambert et al, 2018;Vujanovic et al, 2017). Specific symptoms of post-traumatic stress disorder (PTSD) reflect anhedonia: feelings of detachment from others, diminished emotional responsiveness, and decreased interest in activities (American Psychiatric Association, 1994).…”

Section: Introductionmentioning

confidence: 99%

“…People with more PTA also have a higher incidence of co-morbid psychosis (Kashdan et al, 2006) and major depressive disorder (Feeny et al, 2000;Malta et al, 2009) as well as problematic alcohol, nicotine or other substance use (Debell et al, 2014;Nickerson et al, 2014). As such, PTA is hypothesized to play a role in the development of substance use problems (Vujanovic et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Structural connectivity and risk for anhedonia after trauma: A prospective study and replication

Fani

Michopoulos

Rooij

et al. 2019

Journal of Psychiatric Research

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Anhedonia emerges in some people after psychological trauma, reflected by a loss of interest, diminished affect, and detachment. Structural abnormalities in specific neural pathways at the time of trauma may influence the development of these posttraumatic anhedonia (PTA) symptoms. In this prospective study, we determined whether white matter connectivity at around one month post-trauma predicts PTA and other PTSD symptoms at six months post-trauma. Thirty men and women aged 19-62 were recruited from the emergency department of a Level I trauma center. Participants received diffusion tensor imaging at approximately one month post-trauma and clinical assessments at one and six months post-trauma. Probabilistic tractography was used to examine connectivity of select pathways. A replication sample (N = 57) in an independent, crosssectional dataset of traumatized women was similarly analyzed. Logistic regression results indicated that, after accounting for early PTSD symptoms (at one month) and other clinical risk factors, the integrity of the uncinate fasciculus (UF) uniquely predicted the presence of PTA at six months post-trauma (Beta = −225.6, p < .05). Together, these factors contributed to 76% of the variance in PTA. Integrity of the UF also predicted re-experiencing PTSD symptoms at six months post-trauma. These results were supported in our replication analyses. Our findings indicate that the integrity of the UF around 1 month post-trauma affects vulnerability for the development of anhedonic PTSD symptoms as well as re-experiencing symptoms. Connectivity of this amygdalaventromedial prefrontal pathway appears to be a salient predictor of anhedonia, above and beyond clinical risk factors.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Structural connectivity and risk for anhedonia after trauma: A prospective study and replication

Fani

Michopoulos

Rooij

et al. 2019

Journal of Psychiatric Research

View full text Add to dashboard Cite

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“…However, the reductions in goal-tracking behavior in the TMT-exposed rats is particularly interesting and similar reductions in reward approach behavior have been observed in rats following repeated footshock stress (Woon et al, 2019). One interpretation of this data pattern is that TMT exposure induced an anhedonia-like phenotype, a well-defined symptom of PTSD (APA, 2013, Nawijn et al, 2015, Vujanovic et al, 2017, such that a decrease in sucrose reward led to a decrease in goal-tracking behavior in the task. However, during self-administration training the TMT-exposed animals did not show reduced self-administration of a 10% sucrose solution (Fig.…”

Section: Discussionmentioning

confidence: 52%

The synthetically produced predator odor 2,5-dihydro-2,4,5-trimethylthiazoline increases alcohol self-administration and alters basolateral amygdala response to alcohol in rats

et al. 2020

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Post-traumatic stress disorder (PTSD) is a psychiatric illness that can increase the risk for developing an alcohol use disorder (AUD). While clinical data has been useful in identifying similarities in the neurobiological bases of these disorders, preclinical models are essential for understanding the mechanism(s) by which PTSD increases the risk of developing AUD. The purpose of these studies was to examine if exposure of male Long-Evans rats to the synthetically produced predator odor 2,5-dihydro-2,4,5trimethylthiazoline (TMT) would increase alcohol self-administration, potentially by facilitating transfer of salience towards cues, and alter neuronal response to alcohol as measured by the immediate early gene c-Fos. In Experiment 1 rats exposed to repeated (4x) TMT showed reductions in goal-tracking behavior in Pavlovian conditioned approach, and increases in alcohol self-administration. In Experiment 2 rats exposed to repeated TMT showed blunted basolateral amygdala c-Fos response to alcohol, and increased correlation between medial prefrontal cortex and amygdala subregions. In Experiment 3 rats exposed to single, but not repeated TMT showed increases in alcohol self-administration, and no change in anxiety-like behavior or hyperarousal. In Experiment 4, rats showed no habituation of corticosterone response after 4 TMT exposures. In summary, exposure of male rats to TMT can cause escalations in alcohol self-administration, reductions in goal-tracking behavior, and reduction in BLA response to alcohol. These studies outline and utilize a novel preclinical model that can be used to further neurobiological understanding of the relationship between PTSD and AUD.

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“…Substanzen dienen vorrangig der vorübergehenden Beruhigung des induzierten emotionalen Distresses und der korrelierten physiologischen Stressreaktionen. Die Sucht-inhärente Stressaktivierung wirkt sich wiederum nachteilig intensivierend auf einzelne PTBS-Cluster (v. a. intrusive Traumaerinnerung, autonomes Hyperarousal) aus [ 54 , 197 ].…”

Section: Neurobiologische Konsequenzen Von Substanzmissbrauch Und -Ab...unclassified

Zur Komorbidität von Posttraumatischer Belastungsstörung und Sucht in biopsychosozialer Perspektive

Kapfhammer

2021

Neuropsychiatr

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ZusammenfassungPosttraumatische Belastungsstörung und Substanzkonsumstörungen treten im medizinischen Versorgungssystem häufig koexistent auf. Ihre Komorbidität geht mit schwerwiegenderen akuten klinischen Symptombildern, mit zahlreichen, oft notfallmäßigen Hospitalisierungen und geringeren Behandlungserfolgen einher. Ihre Komorbidität trägt zu dramatisch ungünstigeren Verläufen auf allen biopsychosozialen Ebenen bei. Das Thema Komorbidität von PTBS und Sucht wird auf mehreren Ebenen untersucht: in den Perspektiven von Epidemiologie, Substanzkonsumstörung als Risikofaktor für Trauma und PTBS, Trauma und PTBS als Risikofaktor für Substanzkonsumstörung, neurobiologischen Konsequenzen einer Substanzkonsumstörung für die Neurobiologie von PTBS, gemeinsam geteilten Faktoren der Genetik/Epigenetik, Persönlichkeitsdimensionen und aversiven/traumatogenen Einflüssen in der frühen Entwicklung. Der Hauptfokus der Analyse liegt auf den wechselseitig sich verstärkenden Mechanismen, die der Entwicklung und dem Verlauf beider Störungsbilder inhärent sind.

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Reward functioning in posttraumatic stress and substance use disorders

Cited by 29 publications

References 50 publications

Structural connectivity and risk for anhedonia after trauma: A prospective study and replication

Structural connectivity and risk for anhedonia after trauma: A prospective study and replication

The synthetically produced predator odor 2,5-dihydro-2,4,5-trimethylthiazoline increases alcohol self-administration and alters basolateral amygdala response to alcohol in rats

Zur Komorbidität von Posttraumatischer Belastungsstörung und Sucht in biopsychosozialer Perspektive

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