Reward deficits in behavioural variant frontotemporal dementia include insensitivity to negative stimuli

Perry, David C.; Datta, Samir; Sturm, Virginia E.; Wood, Kristie; Zakrzewski, Jessica; Seeley, William W.; Miller, Bruce L.; Kramer, Joel H.; Rosen, Howard J.

doi:10.1093/brain/awx259

Cited by 36 publications

(25 citation statements)

References 58 publications

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“…Empathy scores were significantly lower in patients with bvFTD who experienced marital infidelity; however, logistic analysis among all patients groups did not show a significant correlation with the IRI-EC or IRI-PT scores, potentially due to the rarity of infidelity in the other neurodegenerative groups. The description of some of some patients' infidelity suggests a lack of concern about negative consequences, consistent with prior studies that show punishment insensitivity in bvFTD (30). Although patients with bvFTD often demonstrate hyposexuality (27,28), some exhibit hypersexuality (31,32).…”

Section: Discussionsupporting

confidence: 81%

Relationship Turmoil and Emotional Empathy in Frontotemporal Dementia

Takeda

Sturm

Rankin

et al. 2019

Alzheimer Disease &Amp; Associated Disorders

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Background: Behavioral variant frontotemporal dementia (bvFTD) is characterized by marked deficits in empathy and social behavior; however, the impact of these symptoms on partner relationships has not been quantitatively measured. Objective: We aimed to determine the effect of empathy loss and behavioral symptoms on partner and familial relationship status in bvFTD. We ascertained whether patients were currently in marriage/partner relationships or were separated/divorced, the timing and duration of these relationships, and whether the patients had relationship infidelity. We investigated the relationship status of 483 patients (156 with bvFTD, 38 with nonfluent variant primary progressive aphasia, 72 with semantic variant primary progressive aphasia, 49 with corticobasal syndrome, 45 with progressive supranuclear palsy syndrome, and 123 with Alzheimer's disease) over the course of follow-up, and correlated relationship status with patients' first visit Interpersonal Reactivity Index and Neuropsychiatric Inventory. Results: Relationship dissolution and infidelity were significantly more frequent among patients with bvFTD than in the other groups. Across all patients, empathy loss was associated with relationship dissolution. In the bvFTD group, patients who experienced relationship dissolution or infidelity had significantly lower empathy than those who did not. Conclusions: Changes in relationship status differed across dementia groups and were associated with empathy decline.

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Section: Discussionsupporting

confidence: 81%

Relationship Turmoil and Emotional Empathy in Frontotemporal Dementia

Takeda

Sturm

Rankin

et al. 2019

Alzheimer Disease &Amp; Associated Disorders

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“…Palminteri found deficits in learning from loss, compared with learning from reward in patients with Huntington's disease and a cohort of patients with insular cortex damage . Similarly, Perry et al showed insensitivity to aversive stimuli but preserved response to rewarding stimuli (noxious and pleasant odors) in frontotemporal dementia. Impaired sensitivity to monetary loss has also been seen in frontotemporal dementia .…”

Section: Discussionmentioning

confidence: 95%

Insensitivity to loss predicts apathy in huntington's disease

et al. 2019

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Background Apathy is a deficit in goal‐directed behavior that significantly affects quality of life and function. It is common in Huntington's disease and other disorders affecting corticostriatal pathways. Deficits in processing of reward, altered effort, and executive dysfunction are associated with apathy in other disorders, but the cognitive processes leading to apathy in Huntington's disease remain largely unknown. A previously reported deficit in learning from losses in Huntington's disease raises the possibility of a hitherto unrecognized mechanism leading to apathy. This study's objective was to delineate the cognitive processes associated with apathy in HD. Methods We tested 51 Huntington's disease participants and 26 controls on a battery of novel and established measures to assess the contribution to apathy in Huntington's disease of executive function, reward value, reward‐effort calculations, instrumental learning, and response to reward and loss. Results Huntington's disase participants had deficits in instrumental learning with impaired response to loss, but no evidence to suggest altered reward‐related behavior or effort. We also saw an executive dysfunction contribution to apathy in Huntington's disease. Discussion We report the novel finding that apathy in Huntington's disease is associated with blunted responses to losses and impaired instrumental learning. This association is consistent with the known early degeneration of the indirect pathway and amygdala involvement in apathy in Huntington's disease, but is previously unreported in any disorder. In keeping with the comparative preservation of the ventral striatum and orbitofrontal cortex in Huntington's disease, reward valuation and reward‐effort calculations did not contribute to apathy. © 2019 International Parkinson and Movement Disorder Society

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“…skin conductance) in response to emotional videos ( Kumfor et al. , 2019 ), unpleasant odours ( Perry et al. , 2017 ) or pain ( Fletcher et al.…”

Section: Discussionmentioning

confidence: 99%

Interactions between decision-making and emotion in behavioral-variant frontotemporal dementia and Alzheimer’s disease

Manuel

Roquet

Landín-Romero

et al. 2020

Social Cognitive and Affective Neuroscience

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Abstract Negative and positive emotions are known to shape decision-making towards more or less impulsive responses respectively. Decision-making and emotion processing are underpinned by shared brain regions including the ventromedio-prefrontal cortex (vmPFC) and the amygdala. How these processes interact at the behavioural and brain levels is still unclear. We used a lesion model to address this question. Study participants included individuals diagnosed with behavioural-variant frontotemporal dementia (bvFTD, n=18), who typically present deficits in decision-making/emotion processing and atrophy of the vmPFC, individuals with Alzheimer’s disease (AD, n=12) who present with atrophy in limbic structures, and age-matched healthy controls (CTRL, n=15). Prior to each choice on the delay discounting task participants were cued with a positive, negative or neutral picture and asked to vividly imagine witnessing the event. As hypothesised, our findings showed that, bvFTD patients were more impulsive than AD and CTRL and did not show any emotion-related modulation of delay discounting rate. In contrast, AD patients showed increased impulsivity when primed by negative emotion. This increased impulsivity was associated with reduced integrity of bilateral amygdala in AD but not in bvFTD. Altogether, our results indicate that decision-making and emotion interact at the level of the amygdala supporting findings from animal studies.

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Reward deficits in behavioural variant frontotemporal dementia include insensitivity to negative stimuli

Cited by 36 publications

References 58 publications

Relationship Turmoil and Emotional Empathy in Frontotemporal Dementia

Relationship Turmoil and Emotional Empathy in Frontotemporal Dementia

Insensitivity to loss predicts apathy in huntington's disease

Interactions between decision-making and emotion in behavioral-variant frontotemporal dementia and Alzheimer’s disease

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