Reward Contingencies Improve Goal-Directed Behavior by Enhancing Posterior Brain Attentional Regions and Increasing Corticostriatal Connectivity in Cocaine Addicts

Rosell-Negre, Patricia; Bustamante, Juan Carlos; Fuentes‐Claramonte, Paola; Costumero, Víctor; Llopis-Llacer, Juan-José; Barrós‐Loscertales, Alfonso

doi:10.1371/journal.pone.0167400

Cited by 10 publications

(10 citation statements)

References 108 publications

(107 reference statements)

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“…Cognitive control alterations in cocaine addiction are related to poor inhibitory control over craving, related to the frontal and parietal regions . However, monetary reward contingencies seem to enhance goal‐directed behavior in cocaine addicts . These results suggest that drug‐alternative reward contingencies (eg, monetary, familiar, social, and labor) may encourage cocaine‐dependent patients to be involved in treatment goals, such as longer periods of abstinence and treatment compliance, by improving cognitive control processes by the interaction of cognitive and motivational processes accordingly.…”

Section: Introductionmentioning

confidence: 93%

Motivational factors modulate left frontoparietal network during cognitive control in cocaine addiction

et al. 2019

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Cocaine addiction is characterized by alterations in motivational and cognitive processes involved in goal‐directed behavior. Recent studies have shown that addictive behaviors can be attributed to alterations in the activity of large functional networks. The aim of this study was to investigate how cocaine addiction affected the left frontoparietal network during goal‐directed behavior in a stop‐signal task (SST) with reward contingencies by correct task performance. Twenty‐eight healthy controls (HC) and 30 abstinent cocaine‐dependent patients (ACD) performed SST with monetary reward contingencies while undergoing a functional magnetic resonance imaging scan. The results showed that the left frontoparietal network (FPN) displayed an effect of cocaine addiction depending on reward contingencies rather than inhibition accuracy; and, second, we observed a negative correlation between dependence severity and the modulation of the left FPN network by the monetary reward in ACD. These findings highlight the role of the left FPN in the motivational effects of cocaine dependence.

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Section: Introductionmentioning

confidence: 93%

Motivational factors modulate left frontoparietal network during cognitive control in cocaine addiction

et al. 2019

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“…Therefore, we speculate that males players may prefer risk decision-making activities. Anyway, these results suggested that strong rewards and the impulse to pursue rewards [ 61 ] seem to be more pronounced in males. This may be the reason why male players are more likely to have IGD.…”

Section: Discussionmentioning

confidence: 99%

Males are more sensitive to reward and less sensitive to loss than females among people with internet gaming disorder: fMRI evidence from a card-guessing task

Zhang

Wang

et al. 2020

BMC Psychiatry

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Background Many studies have found an interesting issue in the Internet gaming disorder (IGD): males are always observed to be the majority. However, there are little research to exploring the differences in the neural mechanisms between males and females in decision-making process among people with IGD. Therefore, explore the reward/loss processing between different gender with IGD could help in understanding the underlying neural mechanism of IGD. Methods Data from functional magnetic resonance imaging (fMRI) were collected from 111 subjects (IGD: 29 males, 25 females; recreational internet game user (RGU): 36 males, 21 females) while they were performing a card-guessing task. We collected and compared their brain features when facing the win and loss conditions in different groups. Results For winning conditions, IGD group showed hypoactivity in the lingual gyrus than RGU group, male players showed hyperactivity in the left caudate nucleus, bilateral cingulate gyrus, right middle frontal gyrus (MFG), right precuneus and inferior parietal lobule relative to the females. And significant sex-by-group interactions results showed higher brain activities in the thalamus, parahippocampal gyrus and lower brain activities in Inferior frontal gyrus (IFG) were observed in males with IGD than females. For losing conditions, IGD group showed hypoactivity in the left lingual gyrus, parahippocampal gyrus and right anterior cingulate cortex (ACC) compared to the RGU group, male players showed hyperactive left caudate nucleus and hypoactive right middle occipital gyrus relative to females. And significant sex-by-group interactions results showed that compared to females with IGD, males with IGD showed decreased brain activities in the IFG and lingual gyrus. Conclusions First, there appeared to be no difference in reward processing between the IGD and RGU group, but IGD showed less sensitivity to loss. Secondly, male players showed more sensitivity to rewards and less sensitivity to losses. Last but not least, males and females showed opposite activation patterns in IGD degree and rewards/losses processing. And male IGD subjects are more sensitive to reward and less sensitive to loss than females, which might be the reason for the gender different rates on IGD.

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“…Imaging studies have examined neural responses to monetary reinforcers and showed a mixture of results, including increases, decreases, or no differences in reward-related activations among CDs, relative to HCs ( Goldstein et al, 2007 ; Jia et al, 2011 ; Patel et al, 2013 ; Bustamante et al, 2014 ; Balodis et al, 2016 ; Konova et al, 2016 ; Rosell-Negre et al, 2016 ; Rose et al, 2017 ). Some reported higher activation to monetary reinforcer in the caudate, putamen, insula, hippocampus, or cingulate gyrus in CDs compared with HCs ( Jia et al, 2011 ; Konova et al, 2016 ; Rose et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Reward-Related Responses and Tonic Craving in Cocaine Addiction: An Imaging Study of the Monetary Incentive Delay Task

Zhornitsky

Dhingra

et al. 2021

International Journal of Neuropsychopharmacology

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Background Cocaine addiction is associated with altered sensitivity to natural reinforcers and intense drug craving. However, previous findings on reward-related responses are mixed and few studies have examined whether reward responses relate to tonic cocaine craving. Methods We combined fMRI and a monetary incentive delay task to investigate these issues. Imaging data were processed with published routines and the results were evaluated with a corrected threshold. We compared reward responses of 50 cocaine dependent individuals (CDs) and 45 healthy controls (HCs) for the ventral striatum (VS) and the whole brain. We also examined the regional responses in association with tonic cocaine craving, as assessed by the Cocaine Craving Questionnaire (CCQ) in CDs. We performed mediation analyses to evaluate the relationship between regional responses, CCQ score, and recent cocaine use. Results The VS showed higher activation to large as compared to small or no wins but this reward-related activity did not differ between CDs and HCs. The precentral gyrus (PCG), anterior insula, and supplementary motor area showed higher activation during large vs. no wins in positive correlation with the CCQ score in CDs. Mediation analyses suggested that days of cocaine use in the prior month contributed to higher CCQ scores and, in turn, PCG reward responses. Conclusions The results highlight a unique relationship between reward responses of the primary motor cortex, tonic cocaine craving and recent cocaine use. The motor cortex may partake in the cognitive motor processes critical to drug seeking behavior in addicted individuals.

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Reward Contingencies Improve Goal-Directed Behavior by Enhancing Posterior Brain Attentional Regions and Increasing Corticostriatal Connectivity in Cocaine Addicts

Cited by 10 publications

References 108 publications

Motivational factors modulate left frontoparietal network during cognitive control in cocaine addiction

Motivational factors modulate left frontoparietal network during cognitive control in cocaine addiction

Males are more sensitive to reward and less sensitive to loss than females among people with internet gaming disorder: fMRI evidence from a card-guessing task

Reward-Related Responses and Tonic Craving in Cocaine Addiction: An Imaging Study of the Monetary Incentive Delay Task

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